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UniProtKB - Q1LZ51 (Q1LZ51_RAT)
Protein
DNA (cytosine-5-)-methyltransferase
Gene
Dnmt3b
Organism
Rattus norvegicus (Rat)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 657 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA (cytosine-5-)-methyltransferase activity Source: RGD
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Source: RGD
- DNA binding Source: RGD
- histone deacetylase binding Source: RGD
- metal ion binding Source: UniProtKB-KW
- methyltransferase activity Source: RGD
- transcription corepressor activity Source: RGD
GO - Biological processi
- C-5 methylation of cytosine Source: RGD
- cellular response to amino acid stimulus Source: RGD
- cellular response to dexamethasone stimulus Source: RGD
- cellular response to hyperoxia Source: RGD
- DNA methylation Source: RGD
- DNA methylation-dependent heterochromatin assembly Source: RGD
- DNA methylation involved in embryo development Source: RGD
- negative regulation of gene expression, epigenetic Source: RGD
- negative regulation of histone H3-K9 methylation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of histone H3-K4 methylation Source: RGD
- positive regulation of neuron differentiation Source: RGD
- protein-containing complex localization Source: RGD
- regulation of gene expression by genetic imprinting Source: RGD
- response to activity Source: RGD
- response to caffeine Source: RGD
- response to cocaine Source: RGD
- response to estradiol Source: RGD
- response to hypoxia Source: RGD
- response to ionizing radiation Source: RGD
- response to toxic substance Source: RGD
- response to vitamin A Source: RGD
- response to xenobiotic stimulus Source: RGD
Keywordsi
Molecular function | DNA-bindingARBA annotation, MethyltransferasePROSITE-ProRule annotationARBA annotation, RepressorARBA annotation, Transferase |
Ligand | Metal-binding, S-adenosyl-L-methioninePROSITE-ProRule annotationARBA annotation, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-212300, PRC2 methylates histones and DNA R-RNO-4655427, SUMOylation of DNA methylation proteins |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:rCG_37517Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1303274, Dnmt3b |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: RGD
Other locations
- chromosome, centromeric region Source: RGD
- heterochromatin Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000010625, Expressed in thymus and 21 other tissues |
Interactioni
GO - Molecular functioni
- histone deacetylase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015482 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 231 – 289 | PWWPInterPro annotationAdd BLAST | 59 | |
Domaini | 428 – 560 | PHD-typeInterPro annotationAdd BLAST | 133 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 225 | DisorderedSequence analysisAdd BLAST | 203 | |
Regioni | 346 – 428 | DisorderedSequence analysisAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 115 – 134 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 162 – 177 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 184 – 205 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 210 – 225 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 358 – 391 | Basic and acidic residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 392 – 406 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 408 – 427 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
eggNOGi | ENOG502QR6U, Eukaryota |
GeneTreei | ENSGT00940000156928 |
HOGENOMi | CLU_006958_9_1_1 |
OMAi | IKPMLDW |
OrthoDBi | 1015783at2759 |
TreeFami | TF329039 |
Family and domain databases
CDDi | cd11728, ADDz_Dnmt3b, 1 hit |
InterProi | View protein in InterPro IPR025766, ADD IPR018117, C5_DNA_meth_AS IPR001525, C5_MeTfrase IPR040552, DNMT3_ADD IPR030488, DNMT3B_ADD IPR000313, PWWP_dom IPR029063, SAM-dependent_MTases IPR011011, Znf_FYVE_PHD |
Pfami | View protein in Pfam PF17980, ADD_DNMT3, 1 hit PF00145, DNA_methylase, 1 hit PF00855, PWWP, 1 hit |
SMARTi | View protein in SMART SM00293, PWWP, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51533, ADD, 1 hit PS00094, C5_MTASE_1, 1 hit PS50812, PWWP, 1 hit PS51679, SAM_MT_C5, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q1LZ51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKGDSRHLNE EEGASGYEDC IIVNGNCSDQ SSDTKDAPSP PVLEAICTEP
60 70 80 90 100
VCTPETRGRR SSSRLSKREV SSLLNYTQDV VGDGDGEADD GDGSDILMMP
110 120 130 140 150
KLTRETKDAR TPSESPAVRT RNSNSISSLE RQRTSPRITR GRQGRYHVQE
160 170 180 190 200
YPVEFPATKS RRRRASSSAS TPWSSPASIE LMEDVTPKSS STPSVDLSQD
210 220 230 240 250
GPQEGMDATQ VDAESRDGDS TEYQDDKEFG IGDLVWGKIK GFSWWPAMVV
260 270 280 290 300
SWKATSKRQA MPGMRWVQWF GDGKFSEIAA DKLVALGLFS QHFNLATFNK
310 320 330 340 350
LVSYRKAMYH TLEKAMVRAG KTFPSRPGDS LEDQLKPMLE WAHGGFKPTG
360 370 380 390 400
IEGLKPNNKQ PEVHKSKVRR SGSRNLEARR RENKSRRRTT IDFAASEYST
410 420 430 440 450
PPKRLKTNSY GGKDRGEDEE SRERMASDVT NNKGNLEDRC LSCGKKNPVS
460 470 480 490 500
FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ SYCTVCCEGR ELLLCSNTSC
510 520 530 540 550
CRCFCVECLE VLVGTGTAED AKLQEPWSCY MCLPQRCHGV LRRRKDWNMR
560 570 580 590 600
LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKDL
610 620 630 640 650
GIKVEKYVAS EVCAESIAVG TIKHEGQIKY VNDVRKITKK NIEEWGPFDL
660 670 680 690 700
VIGGSPCNDL SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW
710 720 730 740 750
MFENVVAMKV NDKKDISRFL ACNPVMIDAI KVSAAHRARY FWGNLPGMNR
760 770 780 790 800
PVIASKNDKL ELQDCLEFSR TAKLKKVQTI TTKSNSIRQG KNQLFPVVMN
810 820 830 840 850
GKDDVLWCTE LERIFGFPAH YTDVSNMGRG ARQKLLGRSW SVPVIRHLFA
PLKDYFACE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JYR2 | A0A0G2JYR2_RAT | DNA (cytosine-5-)-methyltransferase | Dnmt3b | 731 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07054350 Genomic DNA No translation available. AABR07054351 Genomic DNA No translation available. BN000397 mRNA Translation: CAE52319.1 CH474050 Genomic DNA Translation: EDL85992.1 |
RefSeqi | NP_001003959.1, NM_001003959.1 |
Genome annotation databases
Ensembli | ENSRNOT00000015482; ENSRNOP00000015482; ENSRNOG00000010625 |
GeneIDi | 444985 |
KEGGi | rno:444985 |
UCSCi | RGD:1303274, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07054350 Genomic DNA No translation available. AABR07054351 Genomic DNA No translation available. BN000397 mRNA Translation: CAE52319.1 CH474050 Genomic DNA Translation: EDL85992.1 |
RefSeqi | NP_001003959.1, NM_001003959.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015482 |
Genome annotation databases
Ensembli | ENSRNOT00000015482; ENSRNOP00000015482; ENSRNOG00000010625 |
GeneIDi | 444985 |
KEGGi | rno:444985 |
UCSCi | RGD:1303274, rat |
Organism-specific databases
CTDi | 1789 |
RGDi | 1303274, Dnmt3b |
Phylogenomic databases
eggNOGi | ENOG502QR6U, Eukaryota |
GeneTreei | ENSGT00940000156928 |
HOGENOMi | CLU_006958_9_1_1 |
OMAi | IKPMLDW |
OrthoDBi | 1015783at2759 |
TreeFami | TF329039 |
Enzyme and pathway databases
Reactomei | R-RNO-212300, PRC2 methylates histones and DNA R-RNO-4655427, SUMOylation of DNA methylation proteins |
Gene expression databases
Bgeei | ENSRNOG00000010625, Expressed in thymus and 21 other tissues |
Family and domain databases
CDDi | cd11728, ADDz_Dnmt3b, 1 hit |
InterProi | View protein in InterPro IPR025766, ADD IPR018117, C5_DNA_meth_AS IPR001525, C5_MeTfrase IPR040552, DNMT3_ADD IPR030488, DNMT3B_ADD IPR000313, PWWP_dom IPR029063, SAM-dependent_MTases IPR011011, Znf_FYVE_PHD |
Pfami | View protein in Pfam PF17980, ADD_DNMT3, 1 hit PF00145, DNA_methylase, 1 hit PF00855, PWWP, 1 hit |
SMARTi | View protein in SMART SM00293, PWWP, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51533, ADD, 1 hit PS00094, C5_MTASE_1, 1 hit PS50812, PWWP, 1 hit PS51679, SAM_MT_C5, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q1LZ51_RAT | |
Accessioni | Q1LZ51Primary (citable) accession number: Q1LZ51 Secondary accession number(s): F1LQ40 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 30, 2006 |
Last sequence update: | May 30, 2006 | |
Last modified: | January 19, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |