DNA (cytosine-5-)-methyltransferase

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter."
    Sharma D., Bhave S., Gregg E., Uht R.
    Mol Endocrinol 27:1142-1152(2013) [PubMed] [Europe PMC] [Abstract]
• DNA (cytosine-5-)-methyltransferase activity Source: RGD
• DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Source: RGD
• DNA binding Source: RGD
• histone deacetylase binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2."
    Bai S., Ghoshal K., Datta J., Majumder S., Yoon S.O., Jacob S.T.
    Mol Cell Biol 25:751-766(2005) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• methyltransferase activity Source: RGD
• transcription corepressor activity Source: RGD

GO - Biological processⁱ

• C-5 methylation of cytosine Source: RGD
• cellular response to amino acid stimulus Source: RGD
• cellular response to dexamethasone stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter."
    Sharma D., Bhave S., Gregg E., Uht R.
    Mol Endocrinol 27:1142-1152(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to hyperoxia Source: RGDInferred from expression patternⁱ
  • "DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxia."
    Xiong L., Wang F., Huang X., Liu Z.H., Zhao T., Wu L.Y., Wu K., Ding X., Liu S., Wu Y., Zhao Y., Zhu L.L., Fan M.
    FEBS J 279:4318-4326(2012) [PubMed] [Europe PMC] [Abstract]
• DNA methylation Source: RGD
• DNA methylation-dependent heterochromatin assembly Source: RGD
• DNA methylation involved in embryo development Source: RGD
• negative regulation of gene expression, epigenetic Source: RGD
• negative regulation of histone H3-K9 methylation Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of gene expression Source: RGD
• positive regulation of histone H3-K4 methylation Source: RGD
• positive regulation of neuron differentiation Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2."
    Bai S., Ghoshal K., Datta J., Majumder S., Yoon S.O., Jacob S.T.
    Mol Cell Biol 25:751-766(2005) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex localization Source: RGD
• regulation of gene expression by genetic imprinting Source: RGD
• response to activity Source: RGDInferred from expression patternⁱ
  • "Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study."
    Elsner V.R., Lovatel G.A., Moyses F., Bertoldi K., Spindler C., Cechinel L.R., Muotri A.R., Siqueira I.R.
    Exp Gerontol 48:136-139(2013) [PubMed] [Europe PMC] [Abstract]
• response to caffeine Source: RGDInferred from expression patternⁱ
  • "Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis."
    Ping J., Wang J.F., Liu L., Yan Y.E., Liu F., Lei Y.Y., Wang H.
    Toxicology 321:53-61(2014) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: RGDInferred from expression patternⁱ
  • "Cocaine represses protein phosphatase-1Cbeta through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain."
    Pol Bodetto S., Carouge D., Fonteneau M., Dietrich J.B., Zwiller J., Anglard P.
    Neuropharmacology 73:31-40(2013) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1."
    Meunier L., Siddeek B., Vega A., Lakhdari N., Inoubli L., Bellon R.P., Lemaire G., Mauduit C., Benahmed M.
    Endocrinology 153:1936-1947(2012) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from expression patternⁱ
  • "Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior."
    Wang X., Meng F.S., Liu Z.Y., Fan J.M., Hao K., Chen X.Q., Du J.Z.
    Mol Neurobiol 48:544-555(2013) [PubMed] [Europe PMC] [Abstract]
• response to ionizing radiation Source: RGDInferred from expression patternⁱ
  • "Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis."
    Loree J., Koturbash I., Kutanzi K., Baker M., Pogribny I., Kovalchuk O.
    Int J Radiat Biol 82:805-815(2006) [PubMed] [Europe PMC] [Abstract]
• response to toxic substance Source: RGDInferred from expression patternⁱ
  • "[Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats]."
    Zhang Q., Zheng R.Z., Zhang Z.H., Yang L.S., Wang H., Ning H., Huang F.
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 31:92-95(2013) [PubMed] [Europe PMC] [Abstract]
• response to vitamin A Source: RGDInferred from expression patternⁱ
  • "Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart."
    Feng Y., Zhao L.Z., Hong L., Shan C., Shi W., Cai W.
    J Nutr Biochem 24:1373-1380(2013) [PubMed] [Europe PMC] [Abstract]
• response to xenobiotic stimulus Source: RGDInferred from expression patternⁱ
  • "Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis."
    Tryndyak V.P., Muskhelishvili L., Kovalchuk O., Rodriguez-Juarez R., Montgomery B., Churchwell M.I., Ross S.A., Beland F.A., Pogribny I.P.
    Carcinogenesis 27:1713-1720(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: RGDInferred from physical interactionⁱ
  • "DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2."
    Bai S., Ghoshal K., Datta J., Majumder S., Yoon S.O., Jacob S.T.
    Mol Cell Biol 25:751-766(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKGDSRHLNE EEGASGYEDC IIVNGNCSDQ SSDTKDAPSP PVLEAICTEP 
        60         70         80         90        100
VCTPETRGRR SSSRLSKREV SSLLNYTQDV VGDGDGEADD GDGSDILMMP 
       110        120        130        140        150
KLTRETKDAR TPSESPAVRT RNSNSISSLE RQRTSPRITR GRQGRYHVQE 
       160        170        180        190        200
YPVEFPATKS RRRRASSSAS TPWSSPASIE LMEDVTPKSS STPSVDLSQD 
       210        220        230        240        250
GPQEGMDATQ VDAESRDGDS TEYQDDKEFG IGDLVWGKIK GFSWWPAMVV 
       260        270        280        290        300
SWKATSKRQA MPGMRWVQWF GDGKFSEIAA DKLVALGLFS QHFNLATFNK 
       310        320        330        340        350
LVSYRKAMYH TLEKAMVRAG KTFPSRPGDS LEDQLKPMLE WAHGGFKPTG 
       360        370        380        390        400
IEGLKPNNKQ PEVHKSKVRR SGSRNLEARR RENKSRRRTT IDFAASEYST 
       410        420        430        440        450
PPKRLKTNSY GGKDRGEDEE SRERMASDVT NNKGNLEDRC LSCGKKNPVS 
       460        470        480        490        500
FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ SYCTVCCEGR ELLLCSNTSC 
       510        520        530        540        550
CRCFCVECLE VLVGTGTAED AKLQEPWSCY MCLPQRCHGV LRRRKDWNMR 
       560        570        580        590        600
LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKDL 
       610        620        630        640        650
GIKVEKYVAS EVCAESIAVG TIKHEGQIKY VNDVRKITKK NIEEWGPFDL 
       660        670        680        690        700
VIGGSPCNDL SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW 
       710        720        730        740        750
MFENVVAMKV NDKKDISRFL ACNPVMIDAI KVSAAHRARY FWGNLPGMNR 
       760        770        780        790        800
PVIASKNDKL ELQDCLEFSR TAKLKKVQTI TTKSNSIRQG KNQLFPVVMN 
       810        820        830        840        850
GKDDVLWCTE LERIFGFPAH YTDVSNMGRG ARQKLLGRSW SVPVIRHLFA 

PLKDYFACE                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ