Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

DNA methyltransferase 3 beta

Gene

Dnmt3b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei657PROSITE-ProRule annotation1

GO - Molecular functioni

  • chromatin binding Source: RGD
  • DNA (cytosine-5-)-methyltransferase activity Source: Ensembl
  • histone deacetylase binding Source: RGD
  • transcription corepressor activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-212300 PRC2 methylates histones and DNA
R-RNO-4655427 SUMOylation of DNA methylation proteins

Names & Taxonomyi

Protein namesi
Submitted name:
DNA methyltransferase 3 betaImported
Submitted name:
Putative DNA (Cytosine-5) methyltransferase 3bImported
Submitted name:
RCG37517, isoform CRA_aImported
Gene namesi
Name:Dnmt3bImported
Synonyms:dnmt3bImported
ORF Names:rCG_37517Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1303274 Dnmt3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ1LZ51

Expressioni

Gene expression databases

BgeeiENSRNOG00000010625 Expressed in 9 organ(s), highest expression level in liver
ExpressionAtlasiQ1LZ51 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015482

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 289PWWPInterPro annotationAdd BLAST59
Domaini428 – 560PHD-typeInterPro annotationAdd BLAST133

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGHW Eukaryota
ENOG410XQ4Y LUCA
GeneTreeiENSGT00390000008341
HOGENOMiHOG000230875
HOVERGENiHBG051381
KOiK17399
OMAiMKGDTRQ
OrthoDBiEOG091G01TP
TreeFamiTF329039

Family and domain databases

CDDicd11728 ADDz_Dnmt3b, 1 hit
InterProiView protein in InterPro
IPR025766 ADD
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR030488 DNMT3B_ADD
IPR000313 PWWP_dom
IPR029063 SAM-dependent_MTases
IPR011011 Znf_FYVE_PHD
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51533 ADD, 1 hit
PS00094 C5_MTASE_1, 1 hit
PS50812 PWWP, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q1LZ51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGDSRHLNE EEGASGYEDC IIVNGNCSDQ SSDTKDAPSP PVLEAICTEP
60 70 80 90 100
VCTPETRGRR SSSRLSKREV SSLLNYTQDV VGDGDGEADD GDGSDILMMP
110 120 130 140 150
KLTRETKDAR TPSESPAVRT RNSNSISSLE RQRTSPRITR GRQGRYHVQE
160 170 180 190 200
YPVEFPATKS RRRRASSSAS TPWSSPASIE LMEDVTPKSS STPSVDLSQD
210 220 230 240 250
GPQEGMDATQ VDAESRDGDS TEYQDDKEFG IGDLVWGKIK GFSWWPAMVV
260 270 280 290 300
SWKATSKRQA MPGMRWVQWF GDGKFSEIAA DKLVALGLFS QHFNLATFNK
310 320 330 340 350
LVSYRKAMYH TLEKAMVRAG KTFPSRPGDS LEDQLKPMLE WAHGGFKPTG
360 370 380 390 400
IEGLKPNNKQ PEVHKSKVRR SGSRNLEARR RENKSRRRTT IDFAASEYST
410 420 430 440 450
PPKRLKTNSY GGKDRGEDEE SRERMASDVT NNKGNLEDRC LSCGKKNPVS
460 470 480 490 500
FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ SYCTVCCEGR ELLLCSNTSC
510 520 530 540 550
CRCFCVECLE VLVGTGTAED AKLQEPWSCY MCLPQRCHGV LRRRKDWNMR
560 570 580 590 600
LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKDL
610 620 630 640 650
GIKVEKYVAS EVCAESIAVG TIKHEGQIKY VNDVRKITKK NIEEWGPFDL
660 670 680 690 700
VIGGSPCNDL SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW
710 720 730 740 750
MFENVVAMKV NDKKDISRFL ACNPVMIDAI KVSAAHRARY FWGNLPGMNR
760 770 780 790 800
PVIASKNDKL ELQDCLEFSR TAKLKKVQTI TTKSNSIRQG KNQLFPVVMN
810 820 830 840 850
GKDDVLWCTE LERIFGFPAH YTDVSNMGRG ARQKLLGRSW SVPVIRHLFA

PLKDYFACE
Length:859
Mass (Da):96,978
Last modified:May 30, 2006 - v1
Checksum:i10198CDDB3127878
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JYR2A0A0G2JYR2_RAT
DNA methyltransferase 3 beta
Dnmt3b
731Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054350 Genomic DNA No translation available.
AABR07054351 Genomic DNA No translation available.
BN000397 mRNA Translation: CAE52319.1
CH474050 Genomic DNA Translation: EDL85992.1
RefSeqiNP_001003959.1, NM_001003959.1
UniGeneiRn.117353

Genome annotation databases

EnsembliENSRNOT00000015482; ENSRNOP00000015482; ENSRNOG00000010625
GeneIDi444985
KEGGirno:444985
UCSCiRGD:1303274 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054350 Genomic DNA No translation available.
AABR07054351 Genomic DNA No translation available.
BN000397 mRNA Translation: CAE52319.1
CH474050 Genomic DNA Translation: EDL85992.1
RefSeqiNP_001003959.1, NM_001003959.1
UniGeneiRn.117353

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015482

Proteomic databases

PRIDEiQ1LZ51

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015482; ENSRNOP00000015482; ENSRNOG00000010625
GeneIDi444985
KEGGirno:444985
UCSCiRGD:1303274 rat

Organism-specific databases

CTDi1789
RGDi1303274 Dnmt3b

Phylogenomic databases

eggNOGiENOG410IGHW Eukaryota
ENOG410XQ4Y LUCA
GeneTreeiENSGT00390000008341
HOGENOMiHOG000230875
HOVERGENiHBG051381
KOiK17399
OMAiMKGDTRQ
OrthoDBiEOG091G01TP
TreeFamiTF329039

Enzyme and pathway databases

ReactomeiR-RNO-212300 PRC2 methylates histones and DNA
R-RNO-4655427 SUMOylation of DNA methylation proteins

Gene expression databases

BgeeiENSRNOG00000010625 Expressed in 9 organ(s), highest expression level in liver
ExpressionAtlasiQ1LZ51 baseline and differential

Family and domain databases

CDDicd11728 ADDz_Dnmt3b, 1 hit
InterProiView protein in InterPro
IPR025766 ADD
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR030488 DNMT3B_ADD
IPR000313 PWWP_dom
IPR029063 SAM-dependent_MTases
IPR011011 Znf_FYVE_PHD
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51533 ADD, 1 hit
PS00094 C5_MTASE_1, 1 hit
PS50812 PWWP, 1 hit
PS51679 SAM_MT_C5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ1LZ51_RAT
AccessioniPrimary (citable) accession number: Q1LZ51
Secondary accession number(s): F1LQ40
Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again