UniProtKB - Q1LXV6 (Q1LXV6_DANRE)
Protein
RING-type E3 ubiquitin transferase
Gene
rc3h2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 410 – 438 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- double-stranded RNA binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- mRNA binding Source: GO_Central
- RNA stem-loop binding Source: GO_Central
- ubiquitin protein ligase activity Source: GO_Central
GO - Biological processi
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: GO_Central
- protein polyubiquitination Source: GO_Central
- regulation of mRNA stability Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060503-694, rc3h2 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000063050, Expressed in muscle organ and 22 other tissues |
ExpressionAtlasi | Q1LXV6, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 54 | RING-typeInterPro annotationAdd BLAST | 41 | |
Domaini | 410 – 438 | C3H1-typeInterPro annotationAdd BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 470 – 495 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 572 – 595 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 902 – 923 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 936 – 980 | DisorderedSequence analysisAdd BLAST | 45 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 263 – 283 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 572 – 591 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 949 – 977 | PolarSequence analysisAdd BLAST | 29 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 410 – 438 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157685 |
HOGENOMi | CLU_004948_0_0_1 |
PhylomeDBi | Q1LXV6 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032670, RC3H2 IPR041523, ROQ_II IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR13139:SF2, PTHR13139:SF2, 2 hits |
Pfami | View protein in Pfam PF18386, ROQ_II, 1 hit PF00642, zf-CCCH, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00356, ZnF_C3H1, 1 hit |
SUPFAMi | SSF90229, SSF90229, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q1LXV6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVQAAQWTE FLSCPICYNE FDACSHKPIS LGCSHTVCKT CLHKLHRKAC
60 70 80 90 100
PFDQTAISTD IDVLPVNCAL LQLVGVPVPE GEVVSVGNAE DTRHYEVCRM
110 120 130 140 150
CVEELALYLK PVSGGKGVMS ASSSALSRPM QRKLVTLVNC QLVEEEGRVR
160 170 180 190 200
AVRACRSLGE RTVTELILQH QNPQQLSANL WAAVRARGCQ FLGPAMQEDA
210 220 230 240 250
LKLVLLALED GSALSRKVLV LFVVQKLEAR FPQASKTSIG HVVQLLYRAS
260 270 280 290 300
CFKVTKRDED SSLMQLKEEF RTYEALRREH DAQIVHIAME AGLRISPEQW
310 320 330 340 350
SSLLYGDLTH KSHMQSIIDK LQSPESFAKS VQELTIILQR TGDPANLNSL
360 370 380 390 400
RAPLELLAGI DHNPDAAAPS WPELESVLLA VKVVVHGLVE FIQNFSKKSN
410 420 430 440 450
ESPQAQPNSK YKTSMCRDLR QQGGCPRGAS CTFAHTQEEL EKHRMRNRKA
460 470 480 490 500
SGAVRPFLSV PAVMAKSCTK AGSEVGPGGI KNHEKDASED VSPTQLIPRG
510 520 530 540 550
GDQQEDKMLL SGVNGLHVTS LEQNLGSHSQ SPSISSVMST DRHGHVQMRA
560 570 580 590 600
HPEYCSQDQR PYELTPYPQS TIPPKSCSPR FHRSSNVPES MLPPSVGPVY
610 620 630 640 650
PDQHPSVPAL DRLGPSHFGP PSAYSSHGMY TPVYDSRRVW RPPLYPRDGG
660 670 680 690 700
RSNSLPLEVF RSTVYQPPLR ERYNSLDSPY CSTTEQRATM HRAGFDAYTR
710 720 730 740 750
VDELYRHKQE HWVHHHSNVN RASQSSPVFT VDMCPEHPEG VGGGRMTCKC
760 770 780 790 800
HGGEESLAHY SPWSCSTISP FESEPHHLPT HSCSKHLEEE SGGKRWLHVL
810 820 830 840 850
EPYRRLKEED PIIPFGEGPI ISKWGAISRA SRTGFHTTDP VQATASQGCT
860 870 880 890 900
GTTSINFRDY GCHIGHSDLR WGPRSSDSST HSSFLESDHL AVSGLHARRT
910 920 930 940 950
SFSSGTKQGL DLMGKDETEN ETDRDIELEL SALDIEDTET HDCNSEDTME
960 970 980 990
MQSRSQSSHL STVFSDPASS SQLENDLPDR MDANLMKKMA F
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1Q4N1 | F1Q4N1_DANRE | RING-type E3 ubiquitin transferase | rc3h2 | 1,028 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 991 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX248511 Genomic DNA No translation available. CABZ01085376 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000147997; ENSDARP00000113795; ENSDARG00000063050 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX248511 Genomic DNA No translation available. CABZ01085376 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000147997; ENSDARP00000113795; ENSDARG00000063050 |
Organism-specific databases
ZFINi | ZDB-GENE-060503-694, rc3h2 |
Phylogenomic databases
GeneTreei | ENSGT00940000157685 |
HOGENOMi | CLU_004948_0_0_1 |
PhylomeDBi | Q1LXV6 |
Gene expression databases
Bgeei | ENSDARG00000063050, Expressed in muscle organ and 22 other tissues |
ExpressionAtlasi | Q1LXV6, baseline |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032670, RC3H2 IPR041523, ROQ_II IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR13139:SF2, PTHR13139:SF2, 2 hits |
Pfami | View protein in Pfam PF18386, ROQ_II, 1 hit PF00642, zf-CCCH, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00356, ZnF_C3H1, 1 hit |
SUPFAMi | SSF90229, SSF90229, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q1LXV6_DANRE | |
Accessioni | Q1LXV6Primary (citable) accession number: Q1LXV6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 30, 2006 |
Last sequence update: | May 30, 2006 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |