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Entry version 105 (07 Oct 2020)
Sequence version 1 (30 May 2006)
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Protein
Submitted name:

Tumor protein p53-binding protein, 2b

Gene

tp53bp2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • p53 binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tumor protein p53-binding protein, 2bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tp53bp2bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050208-453, tp53bp2b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000054858, Expressed in multi-cellular organism and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1LXN7, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000118842

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 82Ras-associatingInterPro annotationAdd BLAST82
Domaini857 – 955ANK_REP_REGIONInterPro annotationAdd BLAST99
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati890 – 922ANKPROSITE-ProRule annotationAdd BLAST33
Repeati923 – 955ANKPROSITE-ProRule annotationAdd BLAST33
Domaini989 – 1051SH3InterPro annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni399 – 523DisorderedSequence analysisAdd BLAST125
Regioni611 – 645DisorderedSequence analysisAdd BLAST35
Regioni670 – 692DisorderedSequence analysisAdd BLAST23
Regioni719 – 783DisorderedSequence analysisAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili121 – 155Sequence analysisAdd BLAST35
Coiled coili160 – 197Sequence analysisAdd BLAST38
Coiled coili201 – 235Sequence analysisAdd BLAST35
Coiled coili262 – 320Sequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi399 – 417PolarSequence analysisAdd BLAST19
Compositional biasi468 – 490PolarSequence analysisAdd BLAST23
Compositional biasi502 – 520Pro-richSequence analysisAdd BLAST19
Compositional biasi613 – 628PolarSequence analysisAdd BLAST16
Compositional biasi730 – 753PolyampholyteSequence analysisAdd BLAST24
Compositional biasi763 – 777PolarSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0515, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008234_0_0_1

KEGG Orthology (KO)

More...
KOi
K16823

Identification of Orthologs from Complete Genome Data

More...
OMAi
SQPRVYG

Database of Orthologous Groups

More...
OrthoDBi
1041229at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1LXN7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR000159, RA_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00314, RA, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50200, RA, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q1LXN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLTVYLSNS DKHFTELPIT PETLCRDVLD MCKEPGEVDC YLAEMWRGSE
60 70 80 90 100
RVIGDSERII EVLQRWGQQR AEVRFFLRHD RAPGHDTGGH RTPESLAKRS
110 120 130 140 150
NAVKDRLMEN GMAAPHMDIT LSELQEMASR QQQQINAQQQ LLATKEQRLR
160 170 180 190 200
FLKLQDQRQQ QQQVSEQEKL RQLRENAENQ EAKLRRVRAL KGQVEQKRIS
210 220 230 240 250
NSKLVEEIEQ MNGLFQQKQR ELVVAVSRVE ELSRQLDVLR SGKMDMPHEA
260 270 280 290 300
GPSSSGELER LYKELQLRNK LNQEQSAKLQ QQRENLNKRN VEMAAMDKRV
310 320 330 340 350
AELRERLWKK KAALQQKENL PQPSEGQNPQ SVGPSRVAAV GPYIQTTPAP
360 370 380 390 400
PLPPKQEILV KPAYPDGTAT LPKPLPKPTT GGFLTGKISK ISDLFSSTET
410 420 430 440 450
SKSSHVHSST LPRMTSHGSQ EKDPEVDLRP PPLPLRKNQS SEDLLRDSQS
460 470 480 490 500
AGRTFEKVPP PVPSKPKPAL SGQSTFSKLP YSTGTFPGKA RSANQKPPMP
510 520 530 540 550
LPSHNNTLPL PLPPKPDTLP AATVRPFTSD TLAGKDTSTP TTLHKPQTVA
560 570 580 590 600
ASSIYSMYTQ QSTLGKGYQG QSTLTRSQPR LYGKPVIPSS VGQQSFIQDF
610 620 630 640 650
SHIEKICGLD GDQVDQGSSN TAPASSSVEG QEAERVPRPL SPTKLLPFLS
660 670 680 690 700
NSHRLQSDVD LEALRKRLHN APRPLKKRGS ITESEGPGGP NIQKLLYQKT
710 720 730 740 750
TLAAMETIAP AAFFPAEGED GCRPVPNEST RPQEGHHDNT IPECEREEEE
760 770 780 790 800
LTPPPLPPRS PILDDNSNFS TGLNEPQLKE EQEVYGPAAP EPYVEEYPPY
810 820 830 840 850
PPPPYPSMTE QEGPGEDSIN MKAPEVTGQV MLPPGKRTNL RKTGSERINH
860 870 880 890 900
GMRVRFNPLA LLLDSSLEGE YDLVQRIIYE VDDPSLPNDE GITALHNAVC
910 920 930 940 950
AGHTEIVKFL VQYGVNVNAA DSDGWTPLHC AASCNNVQVC KFLVESGAAV
960 970 980 990 1000
YAMTYSDLQT AADKCEEMEE GYAQCSQFLY GVQEKMGIMN RGVVYALWDY
1010 1020 1030 1040 1050
DGESPDELSF KEGDCLTVLR REDGEETEWW WARCADNEGY IPRNLLGLYP
1060
RIKPRQRSLA
Length:1,060
Mass (Da):118,290
Last modified:May 30, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AE9A293DD322B83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QWN1F1QWN1_DANRE
Tumor protein p53-binding protein, ...
tp53bp2b
1,063Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RPM0A0A2R8RPM0_DANRE
Tumor protein p53-binding protein, ...
tp53bp2b
996Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QMF6A0A2R8QMF6_DANRE
Tumor protein p53-binding protein, ...
tp53bp2b
993Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX321898 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001038618.1, NM_001045153.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000136032; ENSDARP00000118842; ENSDARG00000054858

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
568138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:568138

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX321898 Genomic DNA No translation available.
RefSeqiNP_001038618.1, NM_001045153.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000118842

Genome annotation databases

EnsembliENSDART00000136032; ENSDARP00000118842; ENSDARG00000054858
GeneIDi568138
KEGGidre:568138

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
568138
ZFINiZDB-GENE-050208-453, tp53bp2b

Phylogenomic databases

eggNOGiKOG0515, Eukaryota
GeneTreeiENSGT00940000153463
HOGENOMiCLU_008234_0_0_1
KOiK16823
OMAiSQPRVYG
OrthoDBi1041229at2759
PhylomeDBiQ1LXN7

Gene expression databases

BgeeiENSDARG00000054858, Expressed in multi-cellular organism and 24 other tissues
ExpressionAtlasiQ1LXN7, baseline

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR000159, RA_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00314, RA, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF50044, SSF50044, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS50200, RA, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ1LXN7_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1LXN7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: October 7, 2020
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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