UniProtKB - Q1LXK4 (M10B1_DANRE)
Protein
Putative helicase mov-10-B.1
Gene
mov10b.1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).By similarity
Catalytic activityi
- EC:3.6.4.13
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 550 – 557 | ATPBy similarity | 8 |
GO - Molecular functioni
- 5'-3' RNA helicase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- RNA binding Source: GO_Central
GO - Biological processi
- mRNA cleavage involved in gene silencing by miRNA Source: UniProtKB
- post-transcriptional gene silencing by RNA Source: GO_Central
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Biological process | RNA-mediated gene silencing |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mov10b.1 ORF Names:si:dkeyp-38g6.2 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-9089, mov10b.1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000374668 | 1 – 1013 | Putative helicase mov-10-B.1Add BLAST | 1013 |
Proteomic databases
PaxDbi | Q1LXK4 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000061177, Expressed in spleen and 21 other tissues |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 672 – 675 | DEAG box | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1804, Eukaryota |
GeneTreei | ENSGT00940000156024 |
HOGENOMi | CLU_001666_6_1_1 |
InParanoidi | Q1LXK4 |
OMAi | YVDQWHT |
OrthoDBi | 286011at2759 |
PhylomeDBi | Q1LXK4 |
TreeFami | TF323999 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041679, DNA2/NAM7-like_C IPR041677, DNA2/NAM7_AAA_11 IPR026122, MOV-10 IPR027417, P-loop_NTPase |
PANTHERi | PTHR10887:SF322, PTHR10887:SF322, 1 hit |
Pfami | View protein in Pfam PF13086, AAA_11, 2 hits PF13087, AAA_12, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
Q1LXK4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRKYRKKLS RDDIRAVGFD FIEFLDDRET RSTTDRNTLK EIYNEQFRDR
60 70 80 90 100
DGVRDPNFSS VLFALTRSSR TRVTRSEVFF DKKIRVRQND QWSRPYRSQQ
110 120 130 140 150
NHATPHLNDA ISRPSTTRVS DPSSVPEPEN RVIARRRLAK TIMRQGNSED
160 170 180 190 200
MSVFFADKYG VRVSSELQIE DGKIHWCVEG AEVHELKLFV ENTGQEAILF
210 220 230 240 250
TCFSALHYLQ YFTLDDSQRV RKDNPHRLEP NETYEVILRF KSDQIGVYPA
260 270 280 290 300
TLAFEFKENQ DTRPFHIVRF IEAQHRSELT AQLGPTEPFR PKRLDTNQPM
310 320 330 340 350
KWSIDEGFKP ESSSQNFLKF VVPLDNYNCP SYTSALIEVL KGNRSSGKQL
360 370 380 390 400
QEHQLTLESD LSFNNYMDRF DLLLYLEEDQ MRMDIKRYNK KDVSMVRDRD
410 420 430 440 450
KKLLVLELPG VSENRPSVLR GDHLLLTKSE ELQNSNVTKY KGYVHRVELD
460 470 480 490 500
QVKLGFSKRL LERFIDNMKF SVEFTINRLP LRLQHRAVHM VVQHHLKDVL
510 520 530 540 550
FPVASRRLNP VSPSALRLFD QKLEKNPEQK TAVCNIVAGT SKPAPYLVFG
560 570 580 590 600
PPGTGKTVTI VEAIKQVEKN TGGARILACA PSNSAADQLG EKLITSQHVD
610 620 630 640 650
ARNIYRIYAS SRNPKEIPKV LENNSNVEGE NIIFPCKEDL MPYKIVVCTL
660 670 680 690 700
VTAGRLVSGG FPVGHFSHIF VDEAGHAVEP EIVISVAGLL NAETGQLVLA
710 720 730 740 750
GDPKQLGPIL RSPFAIKYGL GLSLLERLMT QNELYQKGDT GFDNRYVTKL
760 770 780 790 800
LQNYRSHPSI LKVPNELFYD NELKACADEI SSRQYCTWEH LPKRGFPVIF
810 820 830 840 850
HGVVGKDERE STSPSFFNTS EIDKIMDYLK KLLLTQAKKG IAKISPKDIG
860 870 880 890 900
IIAPYRKQVE KIRQAIKIHR ELKSLSGIEE LKVGSVEEFQ GQERKVIIVS
910 920 930 940 950
TVRSSKEHII LDDKFNIGFL KNEKRFNVAV TRAKALLIMV GNPIILRTDE
960 970 980 990 1000
IWGRFMNYCI QERGYTGYDI THLEETDVIA ERLLSLNIRQ EITVETEESV
1010
VQQFLSPPWR HEH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX323059 Genomic DNA Translation: CAK11382.2 BC171375 mRNA Translation: AAI71375.1 |
RefSeqi | NP_001037807.2, NM_001044342.2 |
Genome annotation databases
Ensembli | ENSDART00000086946; ENSDARP00000081380; ENSDARG00000061177 |
GeneIDi | 556024 |
KEGGi | dre:556024 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX323059 Genomic DNA Translation: CAK11382.2 BC171375 mRNA Translation: AAI71375.1 |
RefSeqi | NP_001037807.2, NM_001044342.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000081380 |
Proteomic databases
PaxDbi | Q1LXK4 |
Genome annotation databases
Ensembli | ENSDART00000086946; ENSDARP00000081380; ENSDARG00000061177 |
GeneIDi | 556024 |
KEGGi | dre:556024 |
Organism-specific databases
CTDi | 556024 |
ZFINi | ZDB-GENE-030131-9089, mov10b.1 |
Phylogenomic databases
eggNOGi | KOG1804, Eukaryota |
GeneTreei | ENSGT00940000156024 |
HOGENOMi | CLU_001666_6_1_1 |
InParanoidi | Q1LXK4 |
OMAi | YVDQWHT |
OrthoDBi | 286011at2759 |
PhylomeDBi | Q1LXK4 |
TreeFami | TF323999 |
Miscellaneous databases
PROi | PR:Q1LXK4 |
Gene expression databases
Bgeei | ENSDARG00000061177, Expressed in spleen and 21 other tissues |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041679, DNA2/NAM7-like_C IPR041677, DNA2/NAM7_AAA_11 IPR026122, MOV-10 IPR027417, P-loop_NTPase |
PANTHERi | PTHR10887:SF322, PTHR10887:SF322, 1 hit |
Pfami | View protein in Pfam PF13086, AAA_11, 2 hits PF13087, AAA_12, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M10B1_DANRE | |
Accessioni | Q1LXK4Primary (citable) accession number: Q1LXK4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 10, 2021 | |
This is version 98 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families