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UniProtKB - Q1LXK4 (M10B1_DANRE)

Entry version 98 (10 Feb 2021)
Sequence version 2 (08 Apr 2008)
Previous versions | rss
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Protein

Putative helicase mov-10-B.1

Gene

mov10b.1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi550 – 557ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRNA-mediated gene silencing
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative helicase mov-10-B.1 (EC:3.6.4.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mov10b.1
ORF Names:si:dkeyp-38g6.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-9089, mov10b.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003746681 – 1013Putative helicase mov-10-B.1Add BLAST1013

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q1LXK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000061177, Expressed in spleen and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000081380

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi672 – 675DEAG box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1804, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156024

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001666_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q1LXK4

Identification of Orthologs from Complete Genome Data

More...OMAi		YVDQWHT

Database of Orthologous Groups

More...OrthoDBi		286011at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q1LXK4

TreeFam database of animal gene trees

More...TreeFami		TF323999

Family and domain databases

Conserved Domains Database

More...CDDi		cd18808, SF1_C_Upf1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR041679, DNA2/NAM7-like_C
IPR041677, DNA2/NAM7_AAA_11
IPR026122, MOV-10
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR10887:SF322, PTHR10887:SF322, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13086, AAA_11, 2 hits
PF13087, AAA_12, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1LXK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRKYRKKLS RDDIRAVGFD FIEFLDDRET RSTTDRNTLK EIYNEQFRDR 
        60         70         80         90        100
DGVRDPNFSS VLFALTRSSR TRVTRSEVFF DKKIRVRQND QWSRPYRSQQ 
       110        120        130        140        150
NHATPHLNDA ISRPSTTRVS DPSSVPEPEN RVIARRRLAK TIMRQGNSED 
       160        170        180        190        200
MSVFFADKYG VRVSSELQIE DGKIHWCVEG AEVHELKLFV ENTGQEAILF 
       210        220        230        240        250
TCFSALHYLQ YFTLDDSQRV RKDNPHRLEP NETYEVILRF KSDQIGVYPA 
       260        270        280        290        300
TLAFEFKENQ DTRPFHIVRF IEAQHRSELT AQLGPTEPFR PKRLDTNQPM 
       310        320        330        340        350
KWSIDEGFKP ESSSQNFLKF VVPLDNYNCP SYTSALIEVL KGNRSSGKQL 
       360        370        380        390        400
QEHQLTLESD LSFNNYMDRF DLLLYLEEDQ MRMDIKRYNK KDVSMVRDRD 
       410        420        430        440        450
KKLLVLELPG VSENRPSVLR GDHLLLTKSE ELQNSNVTKY KGYVHRVELD 
       460        470        480        490        500
QVKLGFSKRL LERFIDNMKF SVEFTINRLP LRLQHRAVHM VVQHHLKDVL 
       510        520        530        540        550
FPVASRRLNP VSPSALRLFD QKLEKNPEQK TAVCNIVAGT SKPAPYLVFG 
       560        570        580        590        600
PPGTGKTVTI VEAIKQVEKN TGGARILACA PSNSAADQLG EKLITSQHVD 
       610        620        630        640        650
ARNIYRIYAS SRNPKEIPKV LENNSNVEGE NIIFPCKEDL MPYKIVVCTL 
       660        670        680        690        700
VTAGRLVSGG FPVGHFSHIF VDEAGHAVEP EIVISVAGLL NAETGQLVLA 
       710        720        730        740        750
GDPKQLGPIL RSPFAIKYGL GLSLLERLMT QNELYQKGDT GFDNRYVTKL 
       760        770        780        790        800
LQNYRSHPSI LKVPNELFYD NELKACADEI SSRQYCTWEH LPKRGFPVIF 
       810        820        830        840        850
HGVVGKDERE STSPSFFNTS EIDKIMDYLK KLLLTQAKKG IAKISPKDIG 
       860        870        880        890        900
IIAPYRKQVE KIRQAIKIHR ELKSLSGIEE LKVGSVEEFQ GQERKVIIVS 
       910        920        930        940        950
TVRSSKEHII LDDKFNIGFL KNEKRFNVAV TRAKALLIMV GNPIILRTDE 
       960        970        980        990       1000
IWGRFMNYCI QERGYTGYDI THLEETDVIA ERLLSLNIRQ EITVETEESV 
      1010 
VQQFLSPPWR HEH
Length:1,013
Mass (Da):116,407
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47A227CE99D1CC9F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX323059 Genomic DNA Translation: CAK11382.2
BC171375 mRNA Translation: AAI71375.1

NCBI Reference Sequences

More...RefSeqi		NP_001037807.2, NM_001044342.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000086946; ENSDARP00000081380; ENSDARG00000061177

Database of genes from NCBI RefSeq genomes

More...GeneIDi		556024

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:556024

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323059 Genomic DNA Translation: CAK11382.2
BC171375 mRNA Translation: AAI71375.1
RefSeqiNP_001037807.2, NM_001044342.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000081380

Proteomic databases

PaxDbiQ1LXK4

Genome annotation databases

EnsembliENSDART00000086946; ENSDARP00000081380; ENSDARG00000061177
GeneIDi556024
KEGGidre:556024

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		556024
ZFINiZDB-GENE-030131-9089, mov10b.1

Phylogenomic databases

eggNOGiKOG1804, Eukaryota
GeneTreeiENSGT00940000156024
HOGENOMiCLU_001666_6_1_1
InParanoidiQ1LXK4
OMAiYVDQWHT
OrthoDBi286011at2759
PhylomeDBiQ1LXK4
TreeFamiTF323999

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q1LXK4

Gene expression databases

BgeeiENSDARG00000061177, Expressed in spleen and 21 other tissues

Family and domain databases

CDDicd18808, SF1_C_Upf1, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR041679, DNA2/NAM7-like_C
IPR041677, DNA2/NAM7_AAA_11
IPR026122, MOV-10
IPR027417, P-loop_NTPase
PANTHERiPTHR10887:SF322, PTHR10887:SF322, 1 hit
PfamiView protein in Pfam
PF13086, AAA_11, 2 hits
PF13087, AAA_12, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM10B1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1LXK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 8, 2008
Last modified: February 10, 2021
This is version 98 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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