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UniProtKB - Q1LX59 (C2512_DANRE)
Protein
Cholesterol 25-hydroxylase-like protein 1, member 2
Gene
ch25hl1.2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
May catalyze the formation of 25-hydroxycholesterol from cholesterol.
By similarityCofactori
Fe cationBy similarity
GO - Molecular functioni
- C-4 methylsterol oxidase activity Source: GO_Central
- iron ion binding Source: InterPro
- oxidoreductase activity Source: GO_Central
- steroid hydroxylase activity Source: GO_Central
GO - Biological processi
- cholesterol metabolic process Source: GO_Central
- sterol biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Ligand | Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ch25hl1.2Imported ORF Names:si:dkey-24l11.9 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-050419-90, ch25hl1.2 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 39 – 59 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000385451 | 1 – 276 | Cholesterol 25-hydroxylase-like protein 1, member 2Add BLAST | 276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 30 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 164 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q1LX59 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000068138, Expressed in brain and 13 other tissues |
ExpressionAtlasi | Q1LX59, baseline |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 134 – 265 | Fatty acid hydroxylaseSequence analysisAdd BLAST | 132 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 144 – 148 | Histidine box-1Sequence analysis | 5 | |
Motifi | 159 – 163 | Histidine box-2Sequence analysis | 5 | |
Motifi | 240 – 246 | Histidine box-3Sequence analysis | 7 |
Sequence similaritiesi
Belongs to the sterol desaturase family.Sequence analysis
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0873, Eukaryota |
GeneTreei | ENSGT00940000163793 |
HOGENOMi | CLU_047036_5_1_1 |
InParanoidi | Q1LX59 |
OMAi | SSYFIFC |
OrthoDBi | 1493916at2759 |
PhylomeDBi | Q1LX59 |
TreeFami | TF314256 |
Family and domain databases
InterProi | View protein in InterPro IPR006694, Fatty_acid_hydroxylase |
Pfami | View protein in Pfam PF04116, FA_hydroxylase, 1 hit |
i Sequence
Sequence statusi: Complete.
Q1LX59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLAHIFQTI WDFGTKDSVL QPIWDYVRLN HSETLRSPLF PVVLTVSSYF
60 70 80 90 100
VLVLPYLSCD ILGRKWPAIY RYKIQPDKLP TTAMLLHCSG VTLYNHILLV
110 120 130 140 150
IPAAVAQWMW RPPIPLPEQA PTLLELVGGV TGNLLLFDLQ YFIWHFLHHK
160 170 180 190 200
IRWLYVTFHA IHHNYSAPFA LATQCLGGWE LVTVGFWTTL NPVLLRCHLL
210 220 230 240 250
TTWMFMVVHV YVSVEDHCGY DFPWSTSRLI PFGVYGGPSK HDVHHQKPNT
260 270
NFAPHFSHWD KMFGTHADFR FSKPRE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX470164 Genomic DNA Translation: CAK10818.1 |
RefSeqi | NP_001076393.1, NM_001082924.1 |
Genome annotation databases
Ensembli | ENSDART00000098347; ENSDARP00000089118; ENSDARG00000068138 |
GeneIDi | 798384 |
KEGGi | dre:798384 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX470164 Genomic DNA Translation: CAK10818.1 |
RefSeqi | NP_001076393.1, NM_001082924.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000089118 |
Proteomic databases
PaxDbi | Q1LX59 |
Genome annotation databases
Ensembli | ENSDART00000098347; ENSDARP00000089118; ENSDARG00000068138 |
GeneIDi | 798384 |
KEGGi | dre:798384 |
Organism-specific databases
CTDi | 798384 |
ZFINi | ZDB-GENE-050419-90, ch25hl1.2 |
Phylogenomic databases
eggNOGi | KOG0873, Eukaryota |
GeneTreei | ENSGT00940000163793 |
HOGENOMi | CLU_047036_5_1_1 |
InParanoidi | Q1LX59 |
OMAi | SSYFIFC |
OrthoDBi | 1493916at2759 |
PhylomeDBi | Q1LX59 |
TreeFami | TF314256 |
Miscellaneous databases
PROi | PR:Q1LX59 |
Gene expression databases
Bgeei | ENSDARG00000068138, Expressed in brain and 13 other tissues |
ExpressionAtlasi | Q1LX59, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR006694, Fatty_acid_hydroxylase |
Pfami | View protein in Pfam PF04116, FA_hydroxylase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C2512_DANRE | |
Accessioni | Q1LX59Primary (citable) accession number: Q1LX59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | May 30, 2006 | |
Last modified: | September 29, 2021 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families