Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 85 (02 Jun 2021)
Sequence version 2 (13 Nov 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Fanconi-associated nuclease 1

Gene

fan1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.By similarity EC:3.1.4.1

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity, Mg2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi805Magnesium or manganese 2By similarity1
Metal bindingi931Magnesium or manganese 1By similarity1
Metal bindingi931Magnesium or manganese 2By similarity1
Metal bindingi946Magnesium or manganese 1By similarity1
Metal bindingi947Magnesium or manganese 1; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri49 – 77UBZ4-typePROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-6783310, Fanconi Anemia Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fanconi-associated nuclease 1By similarity (EC:3.1.21.-By similarity, EC:3.1.4.1By similarity)
Alternative name(s):
FANCD2/FANCI-associated nuclease 1By similarity
Myotubularin-related protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fan1
Synonyms:mtmr15
ORF Names:si:ch211-163b1.2, si:ch211-201b11.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-6225, fan1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increased DNA damage response, apoptosis and development of abnormalities such as kidney cysts.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112261 – 988Fanconi-associated nuclease 1Add BLAST988

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1LWH4

PRoteomics IDEntifications database

More...
PRIDEi
Q1LWH4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with fancd2 (when monoubiquitinated).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000084286

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1LWH4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini866 – 978VRR-NUCAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 39DisorderedSequence analysisAdd BLAST39
Regioni87 – 115DisorderedSequence analysisAdd BLAST29
Regioni164 – 256DisorderedSequence analysisAdd BLAST93
Regioni269 – 307DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili636 – 663Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 39Polar residuesSequence analysisAdd BLAST32
Compositional biasi164 – 179Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi180 – 243Polar residuesSequence analysisAdd BLAST64
Compositional biasi283 – 302Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UBZ4-type zinc finger specifically binds monoubiquitinated fancd2.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAN1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri49 – 77UBZ4-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2143, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1LWH4

Database of Orthologous Groups

More...
OrthoDBi
1003565at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1LWH4

TreeFam database of animal gene trees

More...
TreeFami
TF312870

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
3.40.1350.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033315, Fan1-like
IPR006642, Rad18_UBZ4
IPR011990, TPR-like_helical_dom_sf
IPR011856, tRNA_endonuc-like_dom_sf
IPR014883, VRR_NUC

The PANTHER Classification System

More...
PANTHERi
PTHR15749, PTHR15749, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08774, VRR_NUC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00990, VRR_NUC, 1 hit
SM00734, ZnF_Rad18, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51908, ZF_UBZ4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q1LWH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESQTGRKSA RRLSMTKKKS QSVCPIKERT SNGGAASITS FFRNTPPSKL
60 70 80 90 100
ACPLCGKLVP RYKINEHIDS QCQNFLVEDD GKQKEITKAP SNSALASNNE
110 120 130 140 150
REKSPGDKDA DTSPFFKKNC AVRRDSSETD SQAKPVKTVG LGSLSSKLSR
160 170 180 190 200
RALRLSDESG VNLTRVSDNE KDHNADLNRS QKENCMNSLT FGSERNGTDA
210 220 230 240 250
DNILETEPEA SNQPQLKNVE KSASDSSISS DVHTSSSSVL KRKSMEIPKN
260 270 280 290 300
DTNTTETCIA HKKSRFFQSS IERGDESKVK SDQTEASSSA YDVPTSKSPI
310 320 330 340 350
KSKTTQEEIE KELNKTPANE HNMLDVEKVG EGSEQQPTRL PYYLRNFRTV
360 370 380 390 400
LEAVLENEDD RRLFNEDDFS TIQSFQQLSV PGQMLYVRLF QRKLKWLQVC
410 420 430 440 450
KVEYTEISTD LRPVVQELVA CGFLQTESEL HDLHEVLDLL PAPELRNLAK
460 470 480 490 500
TFHLGRGGSQ KQQLVEGLLQ LGKQRSLFAG QNNTAAVILK RAKQAAGSCV
510 520 530 540 550
RLCRSSRVVF SRVLLLFTLT DTLEEEDLAS GGQGQLYTIL LVNSGRLAFP
560 570 580 590 600
EYTVHRSARL FKDRDDLIRY ETAMRALQEV IAAMQSGSWE DAYDLYTTAM
610 620 630 640 650
AAWQEIKDSC DLSHQEQLPV FLRCFTVGWT YTRILSRGVE ILQRLKRYED
660 670 680 690 700
AVEQLRNLLS QSVYCVDSRG RWWDRLALNL QQHLKQHEQA IGAIRDGLND
710 720 730 740 750
PLARTGHKLS LYQRASRMKE SASLKKYRLL LRDLPTVHVQ DVTHVTIRGQ
760 770 780 790 800
LFPHEGGMGK SVFLRAASED EGSGGGQGTV LMCSVEDLAL EHYRTLGFDQ
810 820 830 840 850
GIHGEGSTFS TLFGLLMWDI IFMDGVPDVF LNPYQTCPLD LHTDCFYGSR
860 870 880 890 900
REAIEARAEM LREASVETLQ DLIADVWSTQ EGRVCALINW ERFSTPQQAQ
910 920 930 940 950
SLVACLGGHF LSGVFLRMAK DYRHCRGGLP DLVVWSTSSN KYKLVEVKGP
960 970 980
NDRLSQKQQI WLDELRKLGA DVEVCHVTAT GARGARRE
Length:988
Mass (Da):110,984
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94BF5209054E10E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IUX7A0A0R4IUX7_DANRE
Fanconi-associated nuclease
fan1
988Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QCF4A0A2R8QCF4_DANRE
Fanconi-associated nuclease
fan1
947Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4Q → L in AAI51827 (Ref. 2) Curated1
Sequence conflicti15M → V in AAI51827 (Ref. 2) Curated1
Sequence conflicti165R → H in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti165R → H in AAI51827 (Ref. 2) Curated1
Sequence conflicti171K → N in AAI51827 (Ref. 2) Curated1
Sequence conflicti176D → E in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti176D → E in AAI51827 (Ref. 2) Curated1
Sequence conflicti185C → Y in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti185C → Y in AAI51827 (Ref. 2) Curated1
Sequence conflicti192G → E in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti203I → M in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti275D → N in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti337P → H in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti400C → Y in AAI51827 (Ref. 2) Curated1
Sequence conflicti467G → D in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti591D → A in AAI51827 (Ref. 2) Curated1
Sequence conflicti613S → N in CAK04388 (PubMed:23594743).Curated1
Sequence conflicti613S → N in AAI51827 (Ref. 2) Curated1
Sequence conflicti632T → N in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti775G → E in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti781L → V in CAN88260 (PubMed:23594743).Curated1
Sequence conflicti781L → V in AAI51827 (Ref. 2) Curated1
Sequence conflicti868T → I in AAI51827 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX548157 Genomic DNA Translation: CAK04388.1
CT025908 Genomic DNA Translation: CAN88260.1
BC151826 mRNA Translation: AAI51827.1

NCBI Reference Sequences

More...
RefSeqi
NP_001038546.2, NM_001045081.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
565458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:565458

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548157 Genomic DNA Translation: CAK04388.1
CT025908 Genomic DNA Translation: CAN88260.1
BC151826 mRNA Translation: AAI51827.1
RefSeqiNP_001038546.2, NM_001045081.2

3D structure databases

SMRiQ1LWH4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000084286

Proteomic databases

PaxDbiQ1LWH4
PRIDEiQ1LWH4

Genome annotation databases

GeneIDi565458
KEGGidre:565458

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22909
ZFINiZDB-GENE-030131-6225, fan1

Phylogenomic databases

eggNOGiKOG2143, Eukaryota
InParanoidiQ1LWH4
OrthoDBi1003565at2759
PhylomeDBiQ1LWH4
TreeFamiTF312870

Enzyme and pathway databases

ReactomeiR-DRE-6783310, Fanconi Anemia Pathway

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q1LWH4

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.40.1350.10, 1 hit
InterProiView protein in InterPro
IPR033315, Fan1-like
IPR006642, Rad18_UBZ4
IPR011990, TPR-like_helical_dom_sf
IPR011856, tRNA_endonuc-like_dom_sf
IPR014883, VRR_NUC
PANTHERiPTHR15749, PTHR15749, 1 hit
PfamiView protein in Pfam
PF08774, VRR_NUC, 1 hit
SMARTiView protein in SMART
SM00990, VRR_NUC, 1 hit
SM00734, ZnF_Rad18, 1 hit
PROSITEiView protein in PROSITE
PS51908, ZF_UBZ4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAN1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1LWH4
Secondary accession number(s): A5WVQ6, A7MBL6, T1ECT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 2, 2021
This is version 85 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again