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Entry version 114 (07 Oct 2020)
Sequence version 1 (30 May 2006)
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Protein

DNA-directed RNA polymerase subunit

Gene

polr2i

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri83 – 125TFIIS-typePROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-113418, Formation of the Early Elongation Complex
R-DRE-5578749, Transcriptional regulation by small RNAs
R-DRE-674695, RNA Polymerase II Pre-transcription Events
R-DRE-6781823, Formation of TC-NER Pre-Incision Complex
R-DRE-6782135, Dual incision in TC-NER
R-DRE-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DRE-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-DRE-6803529, FGFR2 alternative splicing
R-DRE-6807505, RNA polymerase II transcribes snRNA genes
R-DRE-72086, mRNA Capping
R-DRE-72163, mRNA Splicing - Major Pathway
R-DRE-72165, mRNA Splicing - Minor Pathway
R-DRE-72203, Processing of Capped Intron-Containing Pre-mRNA
R-DRE-73776, RNA Polymerase II Promoter Escape
R-DRE-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DRE-75953, RNA Polymerase II Transcription Initiation
R-DRE-75955, RNA Polymerase II Transcription Elongation
R-DRE-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DRE-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-DRE-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polr2iImported
ORF Names:DKEY-113G17.5-001Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041010-106, polr2i

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationARBA annotation, NucleusUniRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000040443, Expressed in early embryo and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

ARBA annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000059195

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 125TFIIS-typeInterPro annotationAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.ARBA annotation
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri83 – 125TFIIS-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2691, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_093932_0_1_1

KEGG Orthology (KO)

More...
KOi
K03017

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFRFCRD

Database of Orthologous Groups

More...
OrthoDBi
1421187at2759

TreeFam database of animal gene trees

More...
TreeFami
TF103032

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10508, Zn-ribbon_RPB9, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019761, DNA-dir_RNA_pol-M_15_CS
IPR001529, DNA-dir_RNA_pol_M/15kDasu
IPR012164, Rpa12/Rpb9/Rpc10/TFS
IPR034012, Zn_ribbon_RPB9_C
IPR001222, Znf_TFIIS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02150, RNA_POL_M_15KD, 1 hit
PF01096, TFIIS_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005586, RNApol_RpoM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00661, RPOL9, 1 hit
SM00440, ZnF_C2C2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01030, RNA_POL_M_15KD, 1 hit
PS51133, ZF_TFIIS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q1LVK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLEGGNYEP GFVGIRFCQE CNNMLYPKED KENRILLYAC RNCDYQQEAD
60 70 80 90 100
NSCIYVNKIT HEVDELTQII ADVAQDPTLP RTEDHPCPKC GHKEAVFFQS
110 120
HSMKAEDAMR LYYVCTAPHC GHRWTE
Length:126
Mass (Da):14,594
Last modified:May 30, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i379E8D5B7A960A57
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q1LVK1Q1LVK1_DANRE
Polymerase (RNA) II (DNA directed) ...
polr2i
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX663502 Genomic DNA No translation available.
AL928979 Genomic DNA Translation: CAQ13819.1

NCBI Reference Sequences

More...
RefSeqi
NP_001006013.2, NM_001006013.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000059196; ENSDARP00000059195; ENSDARG00000040443
ENSDART00000189528; ENSDARP00000147976; ENSDARG00000110652

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
449992

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:449992

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX663502 Genomic DNA No translation available.
AL928979 Genomic DNA Translation: CAQ13819.1
RefSeqiNP_001006013.2, NM_001006013.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000059195

Genome annotation databases

EnsembliENSDART00000059196; ENSDARP00000059195; ENSDARG00000040443
ENSDART00000189528; ENSDARP00000147976; ENSDARG00000110652
GeneIDi449992
KEGGidre:449992

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5438
ZFINiZDB-GENE-041010-106, polr2i

Phylogenomic databases

eggNOGiKOG2691, Eukaryota
GeneTreeiENSGT00550000075063
HOGENOMiCLU_093932_0_1_1
KOiK03017
OMAiTFRFCRD
OrthoDBi1421187at2759
TreeFamiTF103032

Enzyme and pathway databases

ReactomeiR-DRE-113418, Formation of the Early Elongation Complex
R-DRE-5578749, Transcriptional regulation by small RNAs
R-DRE-674695, RNA Polymerase II Pre-transcription Events
R-DRE-6781823, Formation of TC-NER Pre-Incision Complex
R-DRE-6782135, Dual incision in TC-NER
R-DRE-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DRE-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-DRE-6803529, FGFR2 alternative splicing
R-DRE-6807505, RNA polymerase II transcribes snRNA genes
R-DRE-72086, mRNA Capping
R-DRE-72163, mRNA Splicing - Major Pathway
R-DRE-72165, mRNA Splicing - Minor Pathway
R-DRE-72203, Processing of Capped Intron-Containing Pre-mRNA
R-DRE-73776, RNA Polymerase II Promoter Escape
R-DRE-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DRE-75953, RNA Polymerase II Transcription Initiation
R-DRE-75955, RNA Polymerase II Transcription Elongation
R-DRE-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DRE-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-DRE-9018519, Estrogen-dependent gene expression

Gene expression databases

BgeeiENSDARG00000040443, Expressed in early embryo and 32 other tissues

Family and domain databases

CDDicd10508, Zn-ribbon_RPB9, 1 hit
InterProiView protein in InterPro
IPR019761, DNA-dir_RNA_pol-M_15_CS
IPR001529, DNA-dir_RNA_pol_M/15kDasu
IPR012164, Rpa12/Rpb9/Rpc10/TFS
IPR034012, Zn_ribbon_RPB9_C
IPR001222, Znf_TFIIS
PfamiView protein in Pfam
PF02150, RNA_POL_M_15KD, 1 hit
PF01096, TFIIS_C, 1 hit
PIRSFiPIRSF005586, RNApol_RpoM, 1 hit
SMARTiView protein in SMART
SM00661, RPOL9, 1 hit
SM00440, ZnF_C2C2, 1 hit
PROSITEiView protein in PROSITE
PS01030, RNA_POL_M_15KD, 1 hit
PS51133, ZF_TFIIS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ1LVK2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1LVK2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: October 7, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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