Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).

UniProtKB - Q1LVF0 (LAMC1_DANRE)

Entry version 107 (07 Apr 2021)
Sequence version 2 (20 Feb 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Laminin subunit gamma-1

Gene

lamc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-3000157, Laminin interactions
R-DRE-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DRE-8874081, MET activates PTK2 signaling
R-DRE-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lamc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-021226-3, lamc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000036420120 – 1593Laminin subunit gamma-1Add BLAST1574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi270 ↔ 279PROSITE-ProRule annotation
Disulfide bondi272 ↔ 289PROSITE-ProRule annotation
Disulfide bondi291 ↔ 300PROSITE-ProRule annotation
Disulfide bondi303 ↔ 323PROSITE-ProRule annotation
Disulfide bondi326 ↔ 335PROSITE-ProRule annotation
Disulfide bondi328 ↔ 351PROSITE-ProRule annotation
Disulfide bondi354 ↔ 363PROSITE-ProRule annotation
Disulfide bondi366 ↔ 379PROSITE-ProRule annotation
Disulfide bondi382 ↔ 394PROSITE-ProRule annotation
Disulfide bondi384 ↔ 400PROSITE-ProRule annotation
Disulfide bondi402 ↔ 411PROSITE-ProRule annotation
Disulfide bondi414 ↔ 426PROSITE-ProRule annotation
Disulfide bondi429 ↔ 440PROSITE-ProRule annotation
Disulfide bondi431 ↔ 447PROSITE-ProRule annotation
Disulfide bondi449 ↔ 458PROSITE-ProRule annotation
Disulfide bondi461 ↔ 476PROSITE-ProRule annotation
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi634N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi654N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi708 ↔ 717PROSITE-ProRule annotation
Disulfide bondi710 ↔ 724PROSITE-ProRule annotation
Disulfide bondi726 ↔ 735PROSITE-ProRule annotation
Disulfide bondi738 ↔ 754PROSITE-ProRule annotation
Disulfide bondi757 ↔ 765PROSITE-ProRule annotation
Disulfide bondi759 ↔ 776PROSITE-ProRule annotation
Disulfide bondi779 ↔ 788PROSITE-ProRule annotation
Disulfide bondi791 ↔ 809PROSITE-ProRule annotation
Disulfide bondi812 ↔ 826PROSITE-ProRule annotation
Disulfide bondi814 ↔ 833PROSITE-ProRule annotation
Disulfide bondi836 ↔ 845PROSITE-ProRule annotation
Disulfide bondi848 ↔ 865PROSITE-ProRule annotation
Disulfide bondi868 ↔ 882PROSITE-ProRule annotation
Disulfide bondi870 ↔ 889PROSITE-ProRule annotation
Disulfide bondi891 ↔ 900PROSITE-ProRule annotation
Disulfide bondi903 ↔ 916PROSITE-ProRule annotation
Disulfide bondi919 ↔ 931PROSITE-ProRule annotation
Disulfide bondi921 ↔ 938PROSITE-ProRule annotation
Disulfide bondi940 ↔ 949PROSITE-ProRule annotation
Disulfide bondi952 ↔ 964PROSITE-ProRule annotation
Disulfide bondi967 ↔ 979PROSITE-ProRule annotation
Disulfide bondi969 ↔ 985PROSITE-ProRule annotation
Disulfide bondi987 ↔ 996PROSITE-ProRule annotation
Disulfide bondi999 ↔ 1012PROSITE-ProRule annotation
Glycosylationi1006N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1091N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1379N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q1LVF0

PeptideAtlas

More...PeptideAtlasi		Q1LVF0

PRoteomics IDEntifications database

More...PRIDEi		Q1LVF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000036279, Expressed in paraxial mesoderm and 60 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000024860

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q1LVF0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 269Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini270 – 325Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini326 – 381Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini382 – 428Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Domaini429 – 478Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST50
Domaini505 – 673Laminin IV type APROSITE-ProRule annotationAdd BLAST169
Domaini708 – 756Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST49
Domaini757 – 811Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST55
Domaini812 – 867Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST56
Domaini868 – 918Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST51
Domaini919 – 966Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST48
Domaini967 – 1014Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1014 – 1593Domain II and IBy similarityAdd BLAST580

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1021 – 1580Sequence analysisAdd BLAST560

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1836, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000166185

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002471_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q1LVF0

Identification of Orthologs from Complete Genome Data

More...OMAi		TSEDGPW

Database of Orthologous Groups

More...OrthoDBi		156553at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q1LVF0

TreeFam database of animal gene trees

More...TreeFami		TF352481

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 11 hits
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 5 hits
SM00180, EGF_Lam, 10 hits
SM00281, LamB, 1 hit
SM00136, LamNT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 10 hits
PS50027, EGF_LAM_2, 10 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q1LVF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFSCLLLW TLWAACSHGA MDECIDEDDR PQRCMPEFVN AAFNATVVAT 
        60         70         80         90        100
NTCGSPPEEF CVQTGVTGVT KSCHICNAAD PRLHHGAVYL TDYNQPVQPT 
       110        120        130        140        150
WWQSQTMLAG IQYPNSINLT LHLGKSFDIT YVRLKFHTSR PESFAIYKRS 
       160        170        180        190        200
SEDGPWTPYQ YYSGSCEKTY SKNNRGFIRT GEDEQQALCT DEFSDISPLY 
       210        220        230        240        250
GGNVAFSTLE GRPSAYNFDN SPVLQDWVTA TDIRVTLNRL NTFGDEVFND 
       260        270        280        290        300
PKVLKSYYYA ISDFAVGGRC KCNGHASECV KNEYSKLVCN CKHNTEGADC 
       310        320        330        340        350
NVCKPFYNDR PWRRATAENP NECLPCNCNG KSAECYFDPE LYRATGHGGH 
       360        370        380        390        400
CRNCADNTDG PKCERCLANY YREASGQRCL SCGCNPVGSL STQCDNTGRC 
       410        420        430        440        450
SCKPGVMGDK CDRCQPGYHS LSEAGCRPCS CNPAGSTQEC DVQTGRCQCK 
       460        470        480        490        500
ENVDGFNCDR CKLGYFNLDP QNPQGCTPCF CFQHSTVCES ADGYSVHKIT 
       510        520        530        540        550
STFDRDDEGW KGKQRDDSSV PVQWSPSSGE ISLISEDYFP IYFVAPDKFL 
       560        570        580        590        600
HNQLLSYGQN LTLNFRIQRH DARLSAEDVV LEGSGLRVAV PLIAQGNSYP 
       610        620        630        640        650
GEETQTFVFR LHDTTDYPWR PTIKHADFQK LLYNLTSIMI RGTYSAQSAG 
       660        670        680        690        700
YLDNVSLVTA RRGPGTPARW VEKCTCPQGY LGQHCEQCDQ GFRRSRPELR 
       710        720        730        740        750
RFSTCERCNC NGHSDTCDPE TGMCNCQHNT AGLSCERCKD GFYGDSTVGS 
       760        770        780        790        800
SSDCKACPCP AGATCAVVPK TNEVVCTNCP TGTTGKRCEL CDDGFFGDPL 
       810        820        830        840        850
GEKGPVRACR ACSCNNNIDP NAVGNCNRES GECLKCIYNT AGVFCDRCKQ 
       860        870        880        890        900
GFYGDARAAN VADKCKPCKC SPYGTVDRQT ACSQVTGQCP CLPHVINRDC 
       910        920        930        940        950
GACELGFYNL QSGKGCERCN CNPIGSTNGQ CDIVSGQCEC QPGVTGQHCE 
       960        970        980        990       1000
RCEVNFFGFS SSGCKPCDCD PEGSESAQCK EDGRCHCRPG FVGSRCDMCE 
      1010       1020       1030       1040       1050
ENYFYNRSTP GCQQCPNCYS LVRDKVNQQR QKLLDLQNLI DSLDNTETTV 
      1060       1070       1080       1090       1100
SDKAFEDRLK EAEKTIMDLL EEAQASKEVD KGLLDRLNNI NKTLNNQWNR 
      1110       1120       1130       1140       1150
LQNIKNTVDN TGAQADRARN RVRDAENLIN TAREELDKAK EAISKVDIKI 
      1160       1170       1180       1190       1200
PTTSGDPNNM TLLAEEARKL SEKHKADADQ IEKIAKDAND TSTKAYNMLK 
      1210       1220       1230       1240       1250
KALDGENKTS SDIDELNRKY LEAKDLAKNL EKQAAKVHAE AEEAGNKALK 
      1260       1270       1280       1290       1300
IYANLTSLPP INTKTLEDDA NKIKKEASDL DKLIDKTEKE YNDLREDLRG 
      1310       1320       1330       1340       1350
KETEVRKLLD KGKTEQQTAD QLLARADAAK ALAEEAAKKG KSTFQEAQDI 
      1360       1370       1380       1390       1400
LNNLRDFDKR VNDNKTAAED AMRRIPQINA TINEANDKTR RAEAALGNAA 
      1410       1420       1430       1440       1450
ADAKDAKAKA EEAEKIANDV QKGSAKTKAD AEKAFEDTMK LDKDVDKMMD 
      1460       1470       1480       1490       1500
QLTAAEKELE KKKAEADTDM MMASMASDNA KDAEGNARKA KSAVREVLNT 
      1510       1520       1530       1540       1550
INALLGQLGN IDKVDLSKLN QIDNALKDAK DKMAGSELDR KLKELNDIAK 
      1560       1570       1580       1590 
SQEDMISDYD RQIQEIRADI ANLNDIKNTL PEGCFNTPSL ERP
Length:1,593
Mass (Da):176,206
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A7982905896D403
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti819D → E in AAM61766 (PubMed:12070089).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF468048 mRNA Translation: AAM61766.1
BX681417, BX571812 Genomic DNA Translation: CAK05288.2
BX571812, BX681417 Genomic DNA Translation: CAQ13276.1

NCBI Reference Sequences

More...RefSeqi		NP_775384.1, NM_173277.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000004277; ENSDARP00000024860; ENSDARG00000036279

Database of genes from NCBI RefSeq genomes

More...GeneIDi		286832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:286832

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF468048 mRNA Translation: AAM61766.1
BX681417, BX571812 Genomic DNA Translation: CAK05288.2
BX571812, BX681417 Genomic DNA Translation: CAQ13276.1
RefSeqiNP_775384.1, NM_173277.1

3D structure databases

SMRiQ1LVF0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024860

Proteomic databases

PaxDbiQ1LVF0
PeptideAtlasiQ1LVF0
PRIDEiQ1LVF0

Genome annotation databases

EnsembliENSDART00000004277; ENSDARP00000024860; ENSDARG00000036279
GeneIDi286832
KEGGidre:286832

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3915
ZFINiZDB-GENE-021226-3, lamc1

Phylogenomic databases

eggNOGiKOG1836, Eukaryota
GeneTreeiENSGT00940000166185
HOGENOMiCLU_002471_1_0_1
InParanoidiQ1LVF0
OMAiTSEDGPW
OrthoDBi156553at2759
PhylomeDBiQ1LVF0
TreeFamiTF352481

Enzyme and pathway databases

ReactomeiR-DRE-3000157, Laminin interactions
R-DRE-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DRE-8874081, MET activates PTK2 signaling
R-DRE-8957275, Post-translational protein phosphorylation

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q1LVF0

Gene expression databases

BgeeiENSDARG00000036279, Expressed in paraxial mesoderm and 60 other tissues

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
PfamiView protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 11 hits
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 5 hits
SM00180, EGF_Lam, 10 hits
SM00281, LamB, 1 hit
SM00136, LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 10 hits
PS50027, EGF_LAM_2, 10 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1LVF0
Secondary accession number(s): Q8JHV8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 20, 2007
Last modified: April 7, 2021
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again