UniProtKB - Q1LVF0 (LAMC1_DANRE)
Protein
Laminin subunit gamma-1
Gene
lamc1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.By similarity
GO - Molecular functioni
- extracellular matrix structural constituent Source: GO_Central
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- axon guidance Source: ZFIN
- brain development Source: ZFIN
- brain morphogenesis Source: ZFIN
- cell migration Source: GO_Central
- detection of light stimulus involved in visual perception Source: ZFIN
- eye development Source: ZFIN
- muscle organ development Source: ZFIN
- notochord development Source: ZFIN
- notochord morphogenesis Source: ZFIN
- optokinetic behavior Source: ZFIN
- retinal ganglion cell axon guidance Source: ZFIN
- skeletal muscle tissue development Source: ZFIN
- somite development Source: ZFIN
- substrate adhesion-dependent cell spreading Source: GO_Central
- tissue development Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-DRE-3000157, Laminin interactions R-DRE-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DRE-8874081, MET activates PTK2 signaling R-DRE-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Laminin subunit gamma-1 |
Gene namesi | Name:lamc1 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-021226-3, lamc1 |
Subcellular locationi
Extracellular region or secreted
- basement membrane By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Other locations
- basement membrane Source: GO_Central
Keywords - Cellular componenti
Basement membrane, Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000364201 | 20 – 1593 | Laminin subunit gamma-1Add BLAST | 1574 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 44 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 270 ↔ 279 | PROSITE-ProRule annotation | ||
Disulfide bondi | 272 ↔ 289 | PROSITE-ProRule annotation | ||
Disulfide bondi | 291 ↔ 300 | PROSITE-ProRule annotation | ||
Disulfide bondi | 303 ↔ 323 | PROSITE-ProRule annotation | ||
Disulfide bondi | 326 ↔ 335 | PROSITE-ProRule annotation | ||
Disulfide bondi | 328 ↔ 351 | PROSITE-ProRule annotation | ||
Disulfide bondi | 354 ↔ 363 | PROSITE-ProRule annotation | ||
Disulfide bondi | 366 ↔ 379 | PROSITE-ProRule annotation | ||
Disulfide bondi | 382 ↔ 394 | PROSITE-ProRule annotation | ||
Disulfide bondi | 384 ↔ 400 | PROSITE-ProRule annotation | ||
Disulfide bondi | 402 ↔ 411 | PROSITE-ProRule annotation | ||
Disulfide bondi | 414 ↔ 426 | PROSITE-ProRule annotation | ||
Disulfide bondi | 429 ↔ 440 | PROSITE-ProRule annotation | ||
Disulfide bondi | 431 ↔ 447 | PROSITE-ProRule annotation | ||
Disulfide bondi | 449 ↔ 458 | PROSITE-ProRule annotation | ||
Disulfide bondi | 461 ↔ 476 | PROSITE-ProRule annotation | ||
Glycosylationi | 560 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 634 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 654 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 708 ↔ 717 | PROSITE-ProRule annotation | ||
Disulfide bondi | 710 ↔ 724 | PROSITE-ProRule annotation | ||
Disulfide bondi | 726 ↔ 735 | PROSITE-ProRule annotation | ||
Disulfide bondi | 738 ↔ 754 | PROSITE-ProRule annotation | ||
Disulfide bondi | 757 ↔ 765 | PROSITE-ProRule annotation | ||
Disulfide bondi | 759 ↔ 776 | PROSITE-ProRule annotation | ||
Disulfide bondi | 779 ↔ 788 | PROSITE-ProRule annotation | ||
Disulfide bondi | 791 ↔ 809 | PROSITE-ProRule annotation | ||
Disulfide bondi | 812 ↔ 826 | PROSITE-ProRule annotation | ||
Disulfide bondi | 814 ↔ 833 | PROSITE-ProRule annotation | ||
Disulfide bondi | 836 ↔ 845 | PROSITE-ProRule annotation | ||
Disulfide bondi | 848 ↔ 865 | PROSITE-ProRule annotation | ||
Disulfide bondi | 868 ↔ 882 | PROSITE-ProRule annotation | ||
Disulfide bondi | 870 ↔ 889 | PROSITE-ProRule annotation | ||
Disulfide bondi | 891 ↔ 900 | PROSITE-ProRule annotation | ||
Disulfide bondi | 903 ↔ 916 | PROSITE-ProRule annotation | ||
Disulfide bondi | 919 ↔ 931 | PROSITE-ProRule annotation | ||
Disulfide bondi | 921 ↔ 938 | PROSITE-ProRule annotation | ||
Disulfide bondi | 940 ↔ 949 | PROSITE-ProRule annotation | ||
Disulfide bondi | 952 ↔ 964 | PROSITE-ProRule annotation | ||
Disulfide bondi | 967 ↔ 979 | PROSITE-ProRule annotation | ||
Disulfide bondi | 969 ↔ 985 | PROSITE-ProRule annotation | ||
Disulfide bondi | 987 ↔ 996 | PROSITE-ProRule annotation | ||
Disulfide bondi | 999 ↔ 1012 | PROSITE-ProRule annotation | ||
Glycosylationi | 1006 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1091 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1364 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1379 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q1LVF0 |
PeptideAtlasi | Q1LVF0 |
PRIDEi | Q1LVF0 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000036279, Expressed in paraxial mesoderm and 60 other tissues |
Interactioni
Subunit structurei
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
By similarityProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000024860 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 269 | Laminin N-terminalPROSITE-ProRule annotationAdd BLAST | 240 | |
Domaini | 270 – 325 | Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 326 – 381 | Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 382 – 428 | Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST | 47 | |
Domaini | 429 – 478 | Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 505 – 673 | Laminin IV type APROSITE-ProRule annotationAdd BLAST | 169 | |
Domaini | 708 – 756 | Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 757 – 811 | Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 812 – 867 | Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 868 – 918 | Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 919 – 966 | Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 967 – 1014 | Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1014 – 1593 | Domain II and IBy similarityAdd BLAST | 580 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1021 – 1580 | Sequence analysisAdd BLAST | 560 |
Keywords - Domaini
Coiled coil, Laminin EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG1836, Eukaryota |
GeneTreei | ENSGT00940000166185 |
HOGENOMi | CLU_002471_1_0_1 |
InParanoidi | Q1LVF0 |
OMAi | TSEDGPW |
OrthoDBi | 156553at2759 |
PhylomeDBi | Q1LVF0 |
TreeFami | TF352481 |
Family and domain databases
Gene3Di | 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR002049, Laminin_EGF IPR000034, Laminin_IV IPR008211, Laminin_N IPR038684, Laminin_N_sf |
Pfami | View protein in Pfam PF00052, Laminin_B, 1 hit PF00053, Laminin_EGF, 11 hits PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00180, EGF_Lam, 10 hits SM00281, LamB, 1 hit SM00136, LamNT, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 7 hits PS01186, EGF_2, 2 hits PS01248, EGF_LAM_1, 10 hits PS50027, EGF_LAM_2, 10 hits PS51115, LAMININ_IVA, 1 hit PS51117, LAMININ_NTER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q1LVF0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLFSCLLLW TLWAACSHGA MDECIDEDDR PQRCMPEFVN AAFNATVVAT
60 70 80 90 100
NTCGSPPEEF CVQTGVTGVT KSCHICNAAD PRLHHGAVYL TDYNQPVQPT
110 120 130 140 150
WWQSQTMLAG IQYPNSINLT LHLGKSFDIT YVRLKFHTSR PESFAIYKRS
160 170 180 190 200
SEDGPWTPYQ YYSGSCEKTY SKNNRGFIRT GEDEQQALCT DEFSDISPLY
210 220 230 240 250
GGNVAFSTLE GRPSAYNFDN SPVLQDWVTA TDIRVTLNRL NTFGDEVFND
260 270 280 290 300
PKVLKSYYYA ISDFAVGGRC KCNGHASECV KNEYSKLVCN CKHNTEGADC
310 320 330 340 350
NVCKPFYNDR PWRRATAENP NECLPCNCNG KSAECYFDPE LYRATGHGGH
360 370 380 390 400
CRNCADNTDG PKCERCLANY YREASGQRCL SCGCNPVGSL STQCDNTGRC
410 420 430 440 450
SCKPGVMGDK CDRCQPGYHS LSEAGCRPCS CNPAGSTQEC DVQTGRCQCK
460 470 480 490 500
ENVDGFNCDR CKLGYFNLDP QNPQGCTPCF CFQHSTVCES ADGYSVHKIT
510 520 530 540 550
STFDRDDEGW KGKQRDDSSV PVQWSPSSGE ISLISEDYFP IYFVAPDKFL
560 570 580 590 600
HNQLLSYGQN LTLNFRIQRH DARLSAEDVV LEGSGLRVAV PLIAQGNSYP
610 620 630 640 650
GEETQTFVFR LHDTTDYPWR PTIKHADFQK LLYNLTSIMI RGTYSAQSAG
660 670 680 690 700
YLDNVSLVTA RRGPGTPARW VEKCTCPQGY LGQHCEQCDQ GFRRSRPELR
710 720 730 740 750
RFSTCERCNC NGHSDTCDPE TGMCNCQHNT AGLSCERCKD GFYGDSTVGS
760 770 780 790 800
SSDCKACPCP AGATCAVVPK TNEVVCTNCP TGTTGKRCEL CDDGFFGDPL
810 820 830 840 850
GEKGPVRACR ACSCNNNIDP NAVGNCNRES GECLKCIYNT AGVFCDRCKQ
860 870 880 890 900
GFYGDARAAN VADKCKPCKC SPYGTVDRQT ACSQVTGQCP CLPHVINRDC
910 920 930 940 950
GACELGFYNL QSGKGCERCN CNPIGSTNGQ CDIVSGQCEC QPGVTGQHCE
960 970 980 990 1000
RCEVNFFGFS SSGCKPCDCD PEGSESAQCK EDGRCHCRPG FVGSRCDMCE
1010 1020 1030 1040 1050
ENYFYNRSTP GCQQCPNCYS LVRDKVNQQR QKLLDLQNLI DSLDNTETTV
1060 1070 1080 1090 1100
SDKAFEDRLK EAEKTIMDLL EEAQASKEVD KGLLDRLNNI NKTLNNQWNR
1110 1120 1130 1140 1150
LQNIKNTVDN TGAQADRARN RVRDAENLIN TAREELDKAK EAISKVDIKI
1160 1170 1180 1190 1200
PTTSGDPNNM TLLAEEARKL SEKHKADADQ IEKIAKDAND TSTKAYNMLK
1210 1220 1230 1240 1250
KALDGENKTS SDIDELNRKY LEAKDLAKNL EKQAAKVHAE AEEAGNKALK
1260 1270 1280 1290 1300
IYANLTSLPP INTKTLEDDA NKIKKEASDL DKLIDKTEKE YNDLREDLRG
1310 1320 1330 1340 1350
KETEVRKLLD KGKTEQQTAD QLLARADAAK ALAEEAAKKG KSTFQEAQDI
1360 1370 1380 1390 1400
LNNLRDFDKR VNDNKTAAED AMRRIPQINA TINEANDKTR RAEAALGNAA
1410 1420 1430 1440 1450
ADAKDAKAKA EEAEKIANDV QKGSAKTKAD AEKAFEDTMK LDKDVDKMMD
1460 1470 1480 1490 1500
QLTAAEKELE KKKAEADTDM MMASMASDNA KDAEGNARKA KSAVREVLNT
1510 1520 1530 1540 1550
INALLGQLGN IDKVDLSKLN QIDNALKDAK DKMAGSELDR KLKELNDIAK
1560 1570 1580 1590
SQEDMISDYD RQIQEIRADI ANLNDIKNTL PEGCFNTPSL ERP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 819 | D → E in AAM61766 (PubMed:12070089).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF468048 mRNA Translation: AAM61766.1 BX681417, BX571812 Genomic DNA Translation: CAK05288.2 BX571812, BX681417 Genomic DNA Translation: CAQ13276.1 |
RefSeqi | NP_775384.1, NM_173277.1 |
Genome annotation databases
Ensembli | ENSDART00000004277; ENSDARP00000024860; ENSDARG00000036279 |
GeneIDi | 286832 |
KEGGi | dre:286832 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF468048 mRNA Translation: AAM61766.1 BX681417, BX571812 Genomic DNA Translation: CAK05288.2 BX571812, BX681417 Genomic DNA Translation: CAQ13276.1 |
RefSeqi | NP_775384.1, NM_173277.1 |
3D structure databases
SMRi | Q1LVF0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000024860 |
Proteomic databases
PaxDbi | Q1LVF0 |
PeptideAtlasi | Q1LVF0 |
PRIDEi | Q1LVF0 |
Genome annotation databases
Ensembli | ENSDART00000004277; ENSDARP00000024860; ENSDARG00000036279 |
GeneIDi | 286832 |
KEGGi | dre:286832 |
Organism-specific databases
CTDi | 3915 |
ZFINi | ZDB-GENE-021226-3, lamc1 |
Phylogenomic databases
eggNOGi | KOG1836, Eukaryota |
GeneTreei | ENSGT00940000166185 |
HOGENOMi | CLU_002471_1_0_1 |
InParanoidi | Q1LVF0 |
OMAi | TSEDGPW |
OrthoDBi | 156553at2759 |
PhylomeDBi | Q1LVF0 |
TreeFami | TF352481 |
Enzyme and pathway databases
Reactomei | R-DRE-3000157, Laminin interactions R-DRE-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DRE-8874081, MET activates PTK2 signaling R-DRE-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
PROi | PR:Q1LVF0 |
Gene expression databases
Bgeei | ENSDARG00000036279, Expressed in paraxial mesoderm and 60 other tissues |
Family and domain databases
Gene3Di | 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR002049, Laminin_EGF IPR000034, Laminin_IV IPR008211, Laminin_N IPR038684, Laminin_N_sf |
Pfami | View protein in Pfam PF00052, Laminin_B, 1 hit PF00053, Laminin_EGF, 11 hits PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00180, EGF_Lam, 10 hits SM00281, LamB, 1 hit SM00136, LamNT, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 7 hits PS01186, EGF_2, 2 hits PS01248, EGF_LAM_1, 10 hits PS50027, EGF_LAM_2, 10 hits PS51115, LAMININ_IVA, 1 hit PS51117, LAMININ_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAMC1_DANRE | |
Accessioni | Q1LVF0Primary (citable) accession number: Q1LVF0 Secondary accession number(s): Q8JHV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 3, 2009 |
Last sequence update: | February 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |