Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

A-kinase anchor protein SPHKAP

Gene

sphkap

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein SPHKAP
Alternative name(s):
SPHK1-interactor and AKAP domain-containing protein
Gene namesi
Name:sphkap
ORF Names:si:dkey-223n17.6, si:dkey-99o15.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-050419-32 sphkap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206691 – 1596A-kinase anchor protein SPHKAPAdd BLAST1596

Proteomic databases

PaxDbiQ1LV19
PRIDEiQ1LV19

Expressioni

Gene expression databases

BgeeiENSDARG00000017429 Expressed in 7 organ(s), highest expression level in brain

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000040668

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni829 – 846PKA-RII subunit binding domainBy similarityAdd BLAST18

Domaini

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

Sequence similaritiesi

Belongs to the AKAP110 family.Curated

Phylogenomic databases

eggNOGiENOG410IHCW Eukaryota
ENOG41113DA LUCA
GeneTreeiENSGT00530000063606
HOGENOMiHOG000154389
HOVERGENiHBG108508
InParanoidiQ1LV19
OMAiSKQSSCE
OrthoDBiEOG091G00G3
PhylomeDBiQ1LV19
TreeFamiTF105426

Family and domain databases

InterProiView protein in InterPro
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 3 hits

Sequencei

Sequence statusi: Complete.

Q1LV19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLFFALAG CDGSPLCGGL SQRNQFVRLA CSVTNFQSSA MFEGSESANT
60 70 80 90 100
QEVKSESTLG SSLSACKKVL CSNSVLDSSE YWLKNDKTLC RIGFLEDQHD
110 120 130 140 150
SGCPTICFVN LDRHTSDWHD DNYIKKLASV CPELPRLIES LGVRQPKENE
160 170 180 190 200
ILLLSSLEPP DSCQHDPSHP QSPRTADVCL VHCSCGRRPT QTSSIIFEIN
210 220 230 240 250
KFLIGLQSGQ ERQKHGRLAG QRAAEDDTNR SVSSIEEDFL TASEQLGEDS
260 270 280 290 300
EEDPFRNDPE NSLMPESVKV LRAAHAQKRS EIEREDSEDS ETLCTSSNSQ
310 320 330 340 350
KLSRTYSAPA RGRPTTPKQV KESAGHYATN LAESVLQDAF IRLSQDEPSF
360 370 380 390 400
VAEAAVSVSS DISHSTEAPQ RARACSFELP KIVIVQSPDN SEEVTEWPEV
410 420 430 440 450
QSHATSEHDS GNKAKAKHGT HPPHNSPVGH PAKPLEIALA CAASVIGTIT
460 470 480 490 500
TPQVTEQLTL ESGEEYECED EEEESETDQG EYSFSSAVCG MSQVAGAVAA
510 520 530 540 550
VDLADDSGDN EDLADMYSAS MGLLSVAQAS TAIPLHCSIA EGTSVEAFRA
560 570 580 590 600
NVAEVLLREA SAVFTHRQSY SSVANFLETT HNKIVDGITN PRRPYQEQQD
610 620 630 640 650
VDNFTQEISD SIFQYALEKA EKRKELEGPG KDAPNIEGFL SDCVNNLLFD
660 670 680 690 700
VLCVTSRKIS DISNCNMESC DGQEGSVGYR AYEADSKAGR EALSQLQHLI
710 720 730 740 750
EPSQAYNHGE RRSSVEKLSA LIGKREREQK HIQEERENEA RLKEPYRLAL
760 770 780 790 800
NRVTATMVKE QSDLQGQLGR SDKNADSALP SAESSPLHMQ RGRAGGESET
810 820 830 840 850
RQQSLSSSSG ALVALKMDSG ESKTPVTCFA EDLATTVVSM ATELAAICLE
860 870 880 890 900
NSSGKQPWFC ALNGGSEGPE GLLLPCRTAA ALRRKETQNG TSVTKKHRPP
910 920 930 940 950
RLSEIKRKTE EQPELMERLV NRVVDETVNL DEPTTTDPFA LFASEVTARI
960 970 980 990 1000
MNCPELSVVD TSKSGQSSRS RLQCERWSSR GKASSYESIP EEDADPSGTS
1010 1020 1030 1040 1050
NTLGPGNRLG HNLSRGSSIS KQSSCESITD EFSRFMVNQM ETEGRGFDLL
1060 1070 1080 1090 1100
LDYYAGKNAS SILAAAVQQA ASKKNGHLNV RTSSCLSKQS STESITEEFY
1110 1120 1130 1140 1150
RFMLKDMDKE NKDYSMTKTK EWSNSLLPPS PRTPFCIRQS SVPDRRSSDS
1160 1170 1180 1190 1200
RLTVNSPIKA NSFDGFAQNV HGDSLNIYPT NSVSSSGLCK SDSCLYKRGQ
1210 1220 1230 1240 1250
TDQITDMLIH ETWSSSIESL MRKNKIIAEP SEDSLELDSA DSQPHVQQFA
1260 1270 1280 1290 1300
NRLAADIVES GKSQLGGQQD VTAAACQPHI PVGERRHGFK HSRCNNSGNR
1310 1320 1330 1340 1350
PGVEHQENSC SSYSSSCVRQ AWRGQREVPL IHIEPDQREE ASEEKGGVET
1360 1370 1380 1390 1400
HHREASHQTQ QQSGKGSETA TKSSSDSDRV SSVATVPPAG VEVERRSLSA
1410 1420 1430 1440 1450
SSEESGSGSW AQIATEDDPQ EETTSSFIQL SEGNGNSSTS SLGLADLEGF
1460 1470 1480 1490 1500
PDFSISSNLI SEERERKTSH CQDQADVTLV VLSEVTSGLS TAGSSCQREL
1510 1520 1530 1540 1550
LVLNCDLEPD CVDGELRAAL QWISASELGV PALYFRKTHQ HNLTKLHRVL
1560 1570 1580 1590
QLAGQKAWRV GDLFSAVAQF CQLHQDLELK GRPLPSLFDW ILKTKR
Length:1,596
Mass (Da):174,563
Last modified:May 30, 2006 - v1
Checksum:i00B047ADBB280725
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908751, BX649602 Genomic DNA Translation: CAK05475.1
BX649602, BX908751 Genomic DNA Translation: CAM56518.1
RefSeqiNP_001076514.1, NM_001083045.1
UniGeneiDr.119194

Genome annotation databases

EnsembliENSDART00000040669; ENSDARP00000040668; ENSDARG00000017429
GeneIDi100034387
KEGGidre:100034387

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908751, BX649602 Genomic DNA Translation: CAK05475.1
BX649602, BX908751 Genomic DNA Translation: CAM56518.1
RefSeqiNP_001076514.1, NM_001083045.1
UniGeneiDr.119194

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000040668

Proteomic databases

PaxDbiQ1LV19
PRIDEiQ1LV19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000040669; ENSDARP00000040668; ENSDARG00000017429
GeneIDi100034387
KEGGidre:100034387

Organism-specific databases

CTDi80309
ZFINiZDB-GENE-050419-32 sphkap

Phylogenomic databases

eggNOGiENOG410IHCW Eukaryota
ENOG41113DA LUCA
GeneTreeiENSGT00530000063606
HOGENOMiHOG000154389
HOVERGENiHBG108508
InParanoidiQ1LV19
OMAiSKQSSCE
OrthoDBiEOG091G00G3
PhylomeDBiQ1LV19
TreeFamiTF105426

Miscellaneous databases

PROiPR:Q1LV19

Gene expression databases

BgeeiENSDARG00000017429 Expressed in 7 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSPKAP_DANRE
AccessioniPrimary (citable) accession number: Q1LV19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 30, 2006
Last modified: September 12, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again