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Entry version 104 (07 Oct 2020)
Sequence version 1 (30 May 2006)
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Protein
Submitted name:

PPFIA-binding protein 1b

Gene

ppfibp1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-388844, Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PPFIA-binding protein 1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ppfibp1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060503-47, ppfibp1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1LUM4

PRoteomics IDEntifications database

More...
PRIDEi
Q1LUM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000100057, Expressed in early embryo and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1LUM4, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000090596

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini659 – 723SAMInterPro annotationAdd BLAST65
Domaini736 – 794SAMInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni276 – 297DisorderedSequence analysisAdd BLAST22
Regioni378 – 399DisorderedSequence analysisAdd BLAST22
Regioni438 – 595DisorderedSequence analysisAdd BLAST158

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili106 – 126Sequence analysisAdd BLAST21
Coiled coili162 – 189Sequence analysisAdd BLAST28
Coiled coili206 – 233Sequence analysisAdd BLAST28
Coiled coili244 – 271Sequence analysisAdd BLAST28
Coiled coili337 – 371Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi378 – 393PolyampholyteSequence analysisAdd BLAST16
Compositional biasi450 – 474PolyampholyteSequence analysisAdd BLAST25
Compositional biasi475 – 498PolarSequence analysisAdd BLAST24
Compositional biasi512 – 528PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1899, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203651

Database of Orthologous Groups

More...
OrthoDBi
558442at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1LUM4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09563, SAM_liprin-beta1_2_repeat1, 1 hit
cd09566, SAM_liprin-beta1_2_repeat2, 1 hit
cd09569, SAM_liprin-beta1_2_repeat3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 3 hits
1.20.5.1160, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042180, IF_rod_dom_coil1B
IPR029515, Liprin
IPR037617, Liprin-beta_SAM_rpt_1
IPR037618, Liprin-beta_SAM_rpt_2
IPR037619, Liprin-beta_SAM_rpt_3
IPR030437, PPFIBP1
IPR001660, SAM
IPR013761, SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587, PTHR12587, 1 hit
PTHR12587:SF16, PTHR12587:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536, SAM_1, 2 hits
PF07647, SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454, SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105, SAM_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q1LUM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSDASDMLA AALEQMDGII AGSKALDYSN GIFDCQSPTS PFMGSLRALN
60 70 80 90 100
LLEDLRGILE LMETEERESL RCQIPDSTAD SLVEWLHGHL SNGHISISGD
110 120 130 140 150
VYQDRLNRLE SDKESLVLQV SVLTDQVDAQ GEKIRDLDLC LDEHREKLNA
160 170 180 190 200
TEEMLQQELL CRSALETQKL ELMTEVSNLK LKLAAMDKER LDFDERFGDE
210 220 230 240 250
GLILEINELR YRISEMENER LQYEKKLKST KSLMAKLSSL KLKMGQMQYE
260 270 280 290 300
KQRKEQKIEA LKEELVSLRR QQEGRDGVDL RRLQDESGSR SSTPAGLDGT
310 320 330 340 350
ERVYVMLNVS LRVNVLTFSV SEMDFSLLSL CFADMEVQKM KKAMESLMAA
360 370 380 390 400
NEEKDRKIEE LRQSLMRYKK VQEMVMSAHG RKEKVKEGDS DESNSDSSLS
410 420 430 440 450
MSTALSFSID TDKSLLAYTE EAARAQNEAS TFVSTLQVPS LTVSSPDKAD
460 470 480 490 500
SDSVLEHMQS SDKECEEPDQ SQETPLHESP ESSEVTKSGS QGNLDGGTSE
510 520 530 540 550
KSKKFDEFNK ITTLPPKSTS SSGTAEDDSF GTRKMRSSFG RGFFKLKGGK
560 570 580 590 600
RTASAPNLSE TERDGTDHLD LAGLPQRSAD SDSTHTLPIS PEGKKKSKGF
610 620 630 640 650
KALFGKLKRS QSTTFNLDDN LSESEFKRGG VRATAGPRLG WSRDLQNTNS
660 670 680 690 700
DLDAPFARWS REQVCDWMQE QGLGLYVTLA RQWVSSGQTL LQASQHDLER
710 720 730 740 750
ELGIKHPLHR KKLQLALQAL GSEEDDNKGK LDYHWVTRWL DDIGLPQYKT
760 770 780 790 800
QFDEGRVDGR MLHYMTVDDL LSLKVGSVLH HLSIKRAIQV LRLNNYDPNC
810 820 830 840 850
LRRRPSDENN ISPAEISQWT NHRVMEWLRS VDLAEYAPNL RGSGVHGGLM
860 870 880 890 900
VLEPRFNVET MALLLNIPPN KTLLRRHLAT HFNLLVGSEA QQLKQECLEN
910 920 930 940 950
PDYALLTATA KVKPHKLAFV GFGRKKKQED NEEYVCPMDV EMPKGRSFQK
960 970 980 990 1000
GYRGMELQIY DDDLDRLDQM EDSEGTVRQI GAFSEGINNL TSMLKDDEFF
1010
FPNASVKDDD SNV
Length:1,013
Mass (Da):114,299
Last modified:May 30, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i113ED7AA42AA13F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZVC4B7ZVC4_DANRE
PPFIA-binding protein 1b
ppfibp1b si:dkey-103i16.1
951Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QNZ1A0A2R8QNZ1_DANRE
PPFIA-binding protein 1b
ppfibp1b
993Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YJG7A0A0J9YJG7_DANRE
PPFIA-binding protein 1b
ppfibp1b
319Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QIJ1A0A2R8QIJ1_DANRE
PPFIA-binding protein 1b
ppfibp1b
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX928740 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001038435.1, NM_001044970.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000172690; ENSDARP00000130515; ENSDARG00000100057

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
561961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:561961

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX928740 Genomic DNA No translation available.
RefSeqiNP_001038435.1, NM_001044970.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000090596

Proteomic databases

PaxDbiQ1LUM4
PRIDEiQ1LUM4

Genome annotation databases

EnsembliENSDART00000172690; ENSDARP00000130515; ENSDARG00000100057
GeneIDi561961
KEGGidre:561961

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
561961
ZFINiZDB-GENE-060503-47, ppfibp1b

Phylogenomic databases

eggNOGiKOG1899, Eukaryota
GeneTreeiENSGT00990000203651
OrthoDBi558442at2759
PhylomeDBiQ1LUM4

Enzyme and pathway databases

ReactomeiR-DRE-388844, Receptor-type tyrosine-protein phosphatases

Gene expression databases

BgeeiENSDARG00000100057, Expressed in early embryo and 25 other tissues
ExpressionAtlasiQ1LUM4, baseline

Family and domain databases

CDDicd09563, SAM_liprin-beta1_2_repeat1, 1 hit
cd09566, SAM_liprin-beta1_2_repeat2, 1 hit
cd09569, SAM_liprin-beta1_2_repeat3, 1 hit
Gene3Di1.10.150.50, 3 hits
1.20.5.1160, 2 hits
InterProiView protein in InterPro
IPR042180, IF_rod_dom_coil1B
IPR029515, Liprin
IPR037617, Liprin-beta_SAM_rpt_1
IPR037618, Liprin-beta_SAM_rpt_2
IPR037619, Liprin-beta_SAM_rpt_3
IPR030437, PPFIBP1
IPR001660, SAM
IPR013761, SAM/pointed_sf
PANTHERiPTHR12587, PTHR12587, 1 hit
PTHR12587:SF16, PTHR12587:SF16, 1 hit
PfamiView protein in Pfam
PF00536, SAM_1, 2 hits
PF07647, SAM_2, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 3 hits
SUPFAMiSSF47769, SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ1LUM4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1LUM4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: October 7, 2020
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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