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Entry version 97 (03 Jul 2019)
Sequence version 1 (30 May 2006)
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Protein

Triple functional domain protein

Gene

trio

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2755ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2845Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2732 – 2740ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Triple functional domain protein (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trio
ORF Names:si:dkey-158b13.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060503-334 trioa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002784751 – 3028Triple functional domain proteinAdd BLAST3028

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2636 ↔ 2689PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residue(s).By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1LUA6

PRoteomics IDEntifications database

More...
PRIDEi
Q1LUA6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000081489

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1LUA6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 151CRAL-TRIOPROSITE-ProRule annotationAdd BLAST147
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati162 – 288Spectrin 1Add BLAST127
Repeati294 – 396Spectrin 2Add BLAST103
Repeati399 – 514Spectrin 3Add BLAST116
Repeati517 – 623Spectrin 4Add BLAST107
Repeati624 – 735Spectrin 5Add BLAST112
Repeati858 – 963Spectrin 6Add BLAST106
Repeati1089 – 1195Spectrin 7Add BLAST107
Domaini1243 – 1418DH 1PROSITE-ProRule annotationAdd BLAST176
Domaini1430 – 1542PH 1PROSITE-ProRule annotationAdd BLAST113
Domaini1606 – 1671SH3 1PROSITE-ProRule annotationAdd BLAST66
Domaini1920 – 2096DH 2PROSITE-ProRule annotationAdd BLAST177
Domaini2108 – 2223PH 2PROSITE-ProRule annotationAdd BLAST116
Domaini2480 – 2545SH3 2PROSITE-ProRule annotationAdd BLAST66
Domaini2615 – 2705Ig-like C2-typeAdd BLAST91
Domaini2726 – 2980Protein kinasePROSITE-ProRule annotationAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1796 – 1801Poly-Ser6
Compositional biasi1842 – 1905Ser-richAdd BLAST64
Compositional biasi2272 – 2402Pro-richAdd BLAST131
Compositional biasi2406 – 2483Ser-richAdd BLAST78
Compositional biasi2558 – 2561Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000044462

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1LUA6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1LUA6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR028570 TRIO

The PANTHER Classification System

More...
PANTHERi
PTHR22826:SF104 PTHR22826:SF104, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 2 hits
SSF48726 SSF48726, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q1LUA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAMEVLPIL KEKVAFLSGG RDKRGGPVLT FPSRTNHDRI RHEDLRRLIA
60 70 80 90 100
YLAGIPSEDV CKHGFTVIVD MRGSKWDSIK PLLKILQESF PCCIHIALII
110 120 130 140 150
KPDNFWQKQR TNFGSSKFEF ETTMVSLEGL SKVVDPSQLT ADFEGSLDYN
160 170 180 190 200
HEEWIEIRVA FEDFTGNARH LLARLEEMHE TVTRKDLPQD LDGARRMIEE
210 220 230 240 250
HAALKKRVIK APVEEVDNEG QRLLQRIQSS ESYANRTVPV PPGQREGQGQ
260 270 280 290 300
PNADTQGLVP RITALLEKLH STRQNLHQSW HIRKLQLDQC FQLRLFEQDA
310 320 330 340 350
EKMFDWIMHN KGLFLAGYTE IGNNHPHAME LQTQHNHFAM NCMNVYVNIN
360 370 380 390 400
RIMSVGNRLL EAGHYASQQI KQISGQLEQE WKAFAAALDE RSALLEMSAT
410 420 430 440 450
FHQKCDQYMS NVDSWCKACG EVDLPSELQE LEDAIHHHQG LYEHITAAYS
460 470 480 490 500
EVSQDGKALL DKLQRPLTPG SADSLTASAN YTKAVNHVLD IIHEVLHHQR
510 520 530 540 550
QLENIWQHRK VRLHQRLQLC VFQQDVQQVL DWIENHGEAF LSKHTGVGKS
560 570 580 590 600
LHRARALQKR HEDFEEVAQN TYTNADKLLE AAEQLAQTGE CDPEEIYQAA
610 620 630 640 650
HQLEDRIQDF VRRVEQRKVL LDMSVAFHTH VKELWTWLEE LQKELLDDVY
660 670 680 690 700
AESVEAVQDL IKRFGQQQQT TLQFTVNVIK EGEDLIQQLR DLAISSNKTP
710 720 730 740 750
HNSSINHIES VLQQLDEAQA QMEELFQERK IKLELFLQLR IFERDAIDII
760 770 780 790 800
SDLDSWNEEL SQQMNEFDTE DLTLAEQRLQ HHADKALTMN NLAFHVIHQG
810 820 830 840 850
QELLQYVNEV QASGVELLCD RDVDMATRVQ DLLEFLHEKQ QELDVAAEQH
860 870 880 890 900
RRHLEQCVQL RHLQAEVKQV LGWIRNGESM LNAGLITASS LQEAEQLQRE
910 920 930 940 950
HEQFQHAIEK THQSALQVQQ KAEALLQANH YDMDMIRDCA ENVASHWQQL
960 970 980 990 1000
MLKMEDRLKL VNASVAFYKT SEQVCSVLES LEQEYKREED WCGGADKLGP
1010 1020 1030 1040 1050
NCESDHVTPM ISKHLEQKEA FLKACTLARR NADVFLKYMH RNSVSMPGML
1060 1070 1080 1090 1100
SHVKAPEQQV KNILNELLQR ENRVLHFWTM RKRRLDQCQQ YVVFERSAKQ
1110 1120 1130 1140 1150
ALEWIHDTGE FYLSTHTSTG SSIHHTQELL KEHEDFHITA KQTKERVKLL
1160 1170 1180 1190 1200
IQLADGFCDK GHSHAAEIKK WVTAVDKRYR DFSLRMDKYR TSLEKALGIS
1210 1220 1230 1240 1250
SDSNKASKDL QLDIIPASAP GSEVKLRDAA HELNEEKRKS ARRKDFIMAE
1260 1270 1280 1290 1300
LIQTEKAYVR DLRECMDTYL WEMTSGVEEI PPGIVNKEHI IFGNMQDLYE
1310 1320 1330 1340 1350
FHHNIFLKEL EKYEQLPEDV GHCFVTWADK FQMYVNYCKN KPDSTQLILE
1360 1370 1380 1390 1400
HAGGYFDEIQ QRHRLANSIS SYLIKPVQRI TKYQLLLKEL LTCCEEGKGE
1410 1420 1430 1440 1450
IKDGLEVMLS VPKRANDAMH LSMLEGFDEN IESQGELILQ EAFQVWDPKT
1460 1470 1480 1490 1500
LIRKGRERHL FLFEMSLIFS KEVKDSNGRS KYIYKSKLFT SELGVTEHVE
1510 1520 1530 1540 1550
GDPCKFALWV GRTPTSDNKI VLKASGIENK QDWIKHIREV IQERTVHLKG
1560 1570 1580 1590 1600
ALKEPIHIPK ASTAKHKGRR DGEDLDSQGD GSSQPDTISL ASRTSQNTLD
1610 1620 1630 1640 1650
SDKLSGGCEL TVVIHDFMAG NSNELTIRRG QTVEVLERLH DKPDWCLVRT
1660 1670 1680 1690 1700
TDRSPALEGL VPCAMLCIAH SRSSMEMEGI FNHKDALSVC SNDAIMPGSS
1710 1720 1730 1740 1750
ATLQPGHVMG SQSSPGPKRP GNTLRKWLTS PVRRLSSGKA DGHVKKLAHK
1760 1770 1780 1790 1800
HKKSRDVRKS ADAGSQKDSD DSAATPQDET LEERVRNEGL SSGTLSKSSS
1810 1820 1830 1840 1850
SGMQSCGEEE GEEGADAVPL PPPMAIQQHS LLQPDAQDDK TSSRLSVRPS
1860 1870 1880 1890 1900
SSETPSAAEL VSAIEELVKS KMALEDRPST LSVEQGDSSS PSFNPSDNSL
1910 1920 1930 1940 1950
LSSSSPIDEI EERKTGFFKK RHYVLLELIE TERDYVRDLS LVVEGYMARM
1960 1970 1980 1990 2000
REDGVPDDMK GKDKIVFGNI QQIYDWHKDF FLGELEKCLE DPDRLGPLFL
2010 2020 2030 2040 2050
KHERRLHMYI VYCQNKPKSE HIVSEYIDTY FEDLKQRLGH RLQITDLLIK
2060 2070 2080 2090 2100
PVQRIMKYQL LLKDFLKFSK KIGTDSIELE KAVEVMCIVP KRCNDMMNVG
2110 2120 2130 2140 2150
RLQGFDGKIV AQGRLLLQDT FMVAEPEGGL LNRMKERRVF LFEQIVIFSE
2160 2170 2180 2190 2200
PLDKKRGFSM PGYLYKYSIK VNCLGLEDSV DGDPCKFALT SRTSNSSKDA
2210 2220 2230 2240 2250
FILHSSHPGV RQVWMLQISQ ILESQRNFLN ALTSPIDYQR NHVEGPGVSG
2260 2270 2280 2290 2300
SGVQAGGSGG QMMAPGGGVG VPAGPGSRSR PSRIPQPSRL PQPLRHHSPA
2310 2320 2330 2340 2350
LGPGAHEHDG PDKLSGMSPR PLSRGPSPSC TTEPEPKVKL PASPHPKQTD
2360 2370 2380 2390 2400
SQQTESPAKE IPRATVAPLA LVKPRPGTVS PMASPLATPA FKDSIPPCSP
2410 2420 2430 2440 2450
GPKTGSSSFW SSVPASPASR PASFTFPGDA CDTLSRPNHN QSQRHSTHSK
2460 2470 2480 2490 2500
DADRMSTCSS TSEQSIQSTQ SNGSESSSSS NISTMLVTQD YVALKEDEIN
2510 2520 2530 2540 2550
VGQGEVVQIL ASNQQNMFLV FRAATEQCPA AEGWIPGYVL GHTSAIIPDA
2560 2570 2580 2590 2600
PDGTIKKSSS SWHTSLRIRK KSEKREKDNK KEAKLENGYR KSREGLTNKV
2610 2620 2630 2640 2650
SVKLLNPNYI YDVLPEFLVP LSDVTCDKGE CVTLRCKVCG RPKATVTWKG
2660 2670 2680 2690 2700
PEQKTLTNNG HFSIAYSETG EATLRIVGVT SEDDGSYTCI ATNDIGSVAS
2710 2720 2730 2740 2750
SASLRVLGTT SDGIRVMWKD NFESFYTEVA ELGRGRFSVV KRCDQRGSKR
2760 2770 2780 2790 2800
TVAVKFVNKK LMKRDQVTHE FSVLQRLQHP HLVRLLDTFE TSSSYALVLE
2810 2820 2830 2840 2850
MSDQGRLLDY IVSWGNLTEE KVAFYLRDIL EALQYLHNCR IVHLDLKPEN
2860 2870 2880 2890 2900
LVVEQSPSQP LVKLTDFGDA VQLNSTPYVH PLLGSPEFAA PELVLGDPVS
2910 2920 2930 2940 2950
LSSDLWSLGV LTYVMLSGAS PFLDESVEET CLNICRLDFS FPDDYFQGVS
2960 2970 2980 2990 3000
QAARDFMCLL LRMEPSKRPP ATSCLQEPWL RAGGGRRSAE CIDTSRLISF
3010 3020
IDRRKHQNDL RPLTGIRAFL QTRLQPRI
Length:3,028
Mass (Da):342,362
Last modified:May 30, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD9984AD9BEFEA6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1Q551F1Q551_DANRE
Trio Rho guanine nucleotide exchang...
trioa si:dkey-158b13.2
3,087Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JI09J9JI09_DANRE
Trio Rho guanine nucleotide exchang...
trioa si:dkey-158b13.2
3,075Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX957244, BX950864 Genomic DNA Translation: CAK04109.1
BX950864, BX957244 Genomic DNA Translation: CAK05186.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX957244, BX950864 Genomic DNA Translation: CAK04109.1
BX950864, BX957244 Genomic DNA Translation: CAK05186.1

3D structure databases

SMRiQ1LUA6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000081489

Proteomic databases

PaxDbiQ1LUA6
PRIDEiQ1LUA6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-060503-334 trioa

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA
HOGENOMiHOG000044462
InParanoidiQ1LUA6
PhylomeDBiQ1LUA6

Miscellaneous databases

Protein Ontology

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PROi
PR:Q1LUA6

Family and domain databases

CDDicd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR028570 TRIO
PANTHERiPTHR22826:SF104 PTHR22826:SF104, 1 hit
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits
SUPFAMiSSF48065 SSF48065, 2 hits
SSF48726 SSF48726, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIO_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1LUA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 30, 2006
Last modified: July 3, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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