UniProtKB - Q1LUA2 (Q1LUA2_DANRE)
Protein
Submitted name:
Modulator of VRAC current 1
Gene
mlc1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Biological processi
- protein localization to cell surface Source: ZFIN
- regulation of response to osmotic stress Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Modulator of VRAC current 1Imported |
Gene namesi | Name:mlc1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-050419-145, mlc1 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell-cell junction Source: ZFIN
- cytoplasmic vesicle Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 68 – 87 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 130 – 152 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 159 – 181 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 213 – 236 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 243 – 266 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 286 – 307 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 319 – 340 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSDARG00000063026, Expressed in brain and 9 other tissues |
ExpressionAtlasi | Q1LUA2, baseline |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502QUF1, Eukaryota |
GeneTreei | ENSGT00390000015442 |
OMAi | MLLIQAC |
OrthoDBi | 856594at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR033280, Membrane_MLC1 |
PANTHERi | PTHR17597, PTHR17597, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q1LUA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQREEASAQE VFSYAQMSTL ERNSGVGTLS RHLERERLER DGYTVDVRAS
60 70 80 90 100
DLQLDQPGPL HPCFSYRVWL YSVVVGSSLL IASAFSLYMG NVFPAAMDYL
110 120 130 140 150
RCTAGSSIPA AVVSFAIAKN RQVAVSDFQL VYVSSFAVTT TCLVWFGCKL
160 170 180 190 200
AISPSAININ FNLLLLIVLE VLTASTVILS ARSVDNCCSH SKPVSEGPMI
210 220 230 240 250
VTQTSFPTRL FKAFAVIELI VGIAAVFGGI IALNLGALLP EPYLSVTFFW
260 270 280 290 300
ILAACFPSAI ASHVVAENPS KSLVEMLIAI NSVTSPLLFS ASAFLSSSVI
310 320 330 340 350
SFIEIFLHEV ALAKQSYDIL LLVLMLLLLV PAVLTLATII QCASYKSQVR
360 370 380 390
MGANEWDTLR KKHCEQLASN GTLRDFDKEK AWKAVVVQMA Q
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1QUH3 | F1QUH3_DANRE | Modulator of VRAC current 1 | mlc1 | 392 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX649610 Genomic DNA No translation available. BX957245 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000091729; ENSDARP00000086162; ENSDARG00000063026 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX649610 Genomic DNA No translation available. BX957245 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000122683 |
Proteomic databases
PaxDbi | Q1LUA2 |
Genome annotation databases
Ensembli | ENSDART00000091729; ENSDARP00000086162; ENSDARG00000063026 |
Organism-specific databases
ZFINi | ZDB-GENE-050419-145, mlc1 |
Phylogenomic databases
eggNOGi | ENOG502QUF1, Eukaryota |
GeneTreei | ENSGT00390000015442 |
OMAi | MLLIQAC |
OrthoDBi | 856594at2759 |
Gene expression databases
Bgeei | ENSDARG00000063026, Expressed in brain and 9 other tissues |
ExpressionAtlasi | Q1LUA2, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR033280, Membrane_MLC1 |
PANTHERi | PTHR17597, PTHR17597, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q1LUA2_DANRE | |
Accessioni | Q1LUA2Primary (citable) accession number: Q1LUA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 30, 2006 |
Last sequence update: | June 20, 2018 | |
Last modified: | October 7, 2020 | |
This is version 87 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |