Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 96 (16 Oct 2019)
Sequence version 1 (30 May 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Histone-lysine N-methyltransferase SETDB1-A

Gene

setdb1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1077Zinc 1By similarity1
Metal bindingi1077Zinc 2By similarity1
Metal bindingi1079Zinc 1By similarity1
Metal bindingi1083Zinc 1By similarity1
Metal bindingi1083Zinc 3By similarity1
Metal bindingi1089Zinc 1By similarity1
Metal bindingi1091Zinc 2By similarity1
Metal bindingi1129Zinc 2By similarity1
Metal bindingi1129Zinc 3By similarity1
Metal bindingi1133Zinc 2By similarity1
Metal bindingi1135Zinc 3By similarity1
Metal bindingi1140Zinc 3By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1201S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei1365S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi1371Zinc 4By similarity1
Metal bindingi1424Zinc 4By similarity1
Metal bindingi1426Zinc 4By similarity1
Metal bindingi1431Zinc 4By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETDB1-A (EC:2.1.1.43)
Alternative name(s):
SET domain bifurcated 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:setdb1a
ORF Names:si:ch211-81a5.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-2421 setdb1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002818191 – 1436Histone-lysine N-methyltransferase SETDB1-AAdd BLAST1436

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1L8U8

PRoteomics IDEntifications database

More...
PRIDEi
Q1L8U8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000041243 Expressed in 29 organ(s), highest expression level in mature ovarian follicle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1L8U8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000060441

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1L8U8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini633 – 697Tudor 1Add BLAST65
Domaini724 – 780Tudor 2Add BLAST57
Domaini938 – 1009MBDAdd BLAST72
Domaini1075 – 1148Pre-SETPROSITE-ProRule annotationAdd BLAST74
Domaini1151 – 1411SETPROSITE-ProRule annotationAdd BLAST261
Domaini1420 – 1436Post-SETAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1161 – 1163S-adenosyl-L-methionine bindingBy similarity3
Regioni1368 – 1369S-adenosyl-L-methionine bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1141 Eukaryota
COG2940 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157471

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1L8U8

KEGG Orthology (KO)

More...
KOi
K11421

Database of Orthologous Groups

More...
OrthoDBi
183716at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1L8U8

TreeFam database of animal gene trees

More...
TreeFami
TF106411

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR040880 DUF5604
IPR001739 Methyl_CpG_DNA-bd
IPR007728 Pre-SET_dom
IPR001214 SET_dom
IPR041292 Tudor_4
IPR041291 TUDOR_5

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18300 DUF5604, 1 hit
PF01429 MBD, 1 hit
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
PF18358 Tudor_4, 1 hit
PF18359 TUDOR_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00391 MBD, 1 hit
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54171 SSF54171, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1L8U8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSREKDDENL LRMTKDDLQR WIQAEVERNP HLMQRREQLA QVEEWVKQKE
60 70 80 90 100
RDSTCTRLLY SNACESVLEC ESVMKGLYAL LGLDYRDEDS EEEGGGGQPH
110 120 130 140 150
DVIQIADDEA ERRGNVICNG EDDDNDDLVV IDLGATKETL EPMLEKVTVA
160 170 180 190 200
IQKSSKLVQD LVQMVSKTSM GATSPLSTSS SDINRPSSSS TPEIVRPESV
210 220 230 240 250
TPKLEITNSI TIVKTESLSS VPKISSLFNS SEQCKSIADH DSYFKPTIKT
260 270 280 290 300
EPEWTPLTPW EDSESSPFEK LIKTESQSTD VTPSVMTPNK QPELLSFQST
310 320 330 340 350
TKIKPEPQST QANTELSSPP SNSKLLENHN SLSIAAIKNE SQLKASVSEV
360 370 380 390 400
DLLESDSEQS DNAATKTRFK PSEVTASSKL KSSGDHNSAS ASLNRTDPKV
410 420 430 440 450
RPVTPSGTPP PSKSPPAVDN TASVETNQTD SELPTETPVE ESTLPSNPKE
460 470 480 490 500
AVIMSDAEST DKTEKPQTRK KSSKPSVTTT SPESRLTSSK SPPVTKTSST
510 520 530 540 550
QKETARAQSP SDSIDESADM EDSPDEPSNS PTESPTKTPD KTTRNDAPAK
560 570 580 590 600
PSKAKKSSKH SSSESSKTLK EIKLKVGAAV LGKKRHNHWS RGTVQEVETE
610 620 630 640 650
DDGNTYKVEF KKGKTIVLSA NHVAAYKPPS LKDLYIGCRV VASAKSENGK
660 670 680 690 700
SLYNAGVMVE LPERKNRMRF LVFFDDGLAT YLALPDLYFV CKQTKKVWRE
710 720 730 740 750
IKDESSRKQV KDYLQVYPNP IAVVLRLGQE TKAVRNGQFE DCTVLQLDGS
760 770 780 790 800
LVQICYKNDK QKEWIYKGSD KLEHILTIKN RHKQHSHKKH HSPEGKTQSS
810 820 830 840 850
QPKTLHSSKS ASTSTSSANV SPVSSDSVSP ARVTRQSDKT KTSISPQKIM
860 870 880 890 900
SPAFQPKVVL QKISLPSSIS PAARVSNSNT NSSLISAKRP APDEEEDEYF
910 920 930 940 950
SEDEVEVLEQ EQNKSVYLHQ RCCPACLEEV RPHQVDIHHG KNPLLIPLLF
960 970 980 990 1000
KFRRMTARRR IDGKLFFHIF YRSPCGRSLC DMQEVQDYLF ETRCDFLFLE
1010 1020 1030 1040 1050
MFCMDPFVLV NRARPPSTTT GQPHLYLPDI SEGKEVMPVP CVNEVDNTLA
1060 1070 1080 1090 1100
PNVTYTKDRV PARGVFINTS SDFMVGCDCT DGCRDRSKCA CHKLTIEATS
1110 1120 1130 1140 1150
LCTGGPVDVS AGYTHKRLPT SLPTGVYECN PLCRCDPRMC SNRLVQHGMQ
1160 1170 1180 1190 1200
LRLELFMTQH KGWGIRCKDD VPKGTFVCVF TGKIVNEDKM NEDDTMSGNE
1210 1220 1230 1240 1250
YLANLDFIEG VEKLKEGYES EAYCSDTEVE SSKKTITMKT GPLLKNSLYK
1260 1270 1280 1290 1300
EDSSSGEEPM EVDTAKDKVK VHDKPLGERK LPNKPHETPK DTQKKISELR
1310 1320 1330 1340 1350
KNDGQESSGP KRCFAIKSFQ RRVKPLESTE AQKEKTKTPK NTRGLFNDED
1360 1370 1380 1390 1400
ACYIIDARQE GNLGRYINHS CSPNLFVQNV FVDTHDLRFP WVAFFASKRI
1410 1420 1430
KAGTELTWDY NYEVGSVEGK VLLCCCGSLR CTGRLL
Length:1,436
Mass (Da):160,025
Last modified:May 30, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C4174768AA95B5B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR626935 Genomic DNA Translation: CAK04995.1

NCBI Reference Sequences

More...
RefSeqi
NP_001038232.1, NM_001044767.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000060442; ENSDARP00000060441; ENSDARG00000041243
ENSDART00000088336; ENSDARP00000082769; ENSDARG00000041243

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
553292

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:553292

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626935 Genomic DNA Translation: CAK04995.1
RefSeqiNP_001038232.1, NM_001044767.2

3D structure databases

SMRiQ1L8U8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060441

Proteomic databases

PaxDbiQ1L8U8
PRIDEiQ1L8U8

Genome annotation databases

EnsembliENSDART00000060442; ENSDARP00000060441; ENSDARG00000041243
ENSDART00000088336; ENSDARP00000082769; ENSDARG00000041243
GeneIDi553292
KEGGidre:553292

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
553292
ZFINiZDB-GENE-030131-2421 setdb1a

Phylogenomic databases

eggNOGiKOG1141 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000157471
InParanoidiQ1L8U8
KOiK11421
OrthoDBi183716at2759
PhylomeDBiQ1L8U8
TreeFamiTF106411

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q1L8U8

Gene expression databases

BgeeiENSDARG00000041243 Expressed in 29 organ(s), highest expression level in mature ovarian follicle
ExpressionAtlasiQ1L8U8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016177 DNA-bd_dom_sf
IPR040880 DUF5604
IPR001739 Methyl_CpG_DNA-bd
IPR007728 Pre-SET_dom
IPR001214 SET_dom
IPR041292 Tudor_4
IPR041291 TUDOR_5
PfamiView protein in Pfam
PF18300 DUF5604, 1 hit
PF01429 MBD, 1 hit
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
PF18358 Tudor_4, 1 hit
PF18359 TUDOR_5, 1 hit
SMARTiView protein in SMART
SM00391 MBD, 1 hit
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTB1A_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1L8U8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 30, 2006
Last modified: October 16, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again