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Entry version 96 (05 Jun 2019)
Sequence version 2 (20 Jan 2016)
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Protein
Submitted name:

Zinc finger protein 687b

Gene

znf687b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 687bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:znf687bImported
Synonyms:si:dkey-204a24.9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041111-214 znf687b

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000019299 Expressed in 18 organ(s), highest expression level in mature ovarian follicle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1L8S9 baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini674 – 692C2H2-typeInterPro annotationAdd BLAST19
Domaini982 – 1009C2H2-typeInterPro annotationAdd BLAST28
Domaini1013 – 1041C2H2-typeInterPro annotationAdd BLAST29
Domaini1122 – 1145C2H2-typeInterPro annotationAdd BLAST24
Domaini1152 – 1180C2H2-typeInterPro annotationAdd BLAST29
Domaini1317 – 1345C2H2-typeInterPro annotationAdd BLAST29
Domaini1375 – 1410C2H2-typeInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 481DisorderedSequence analysisAdd BLAST458
Regioni504 – 538DisorderedSequence analysisAdd BLAST35
Regioni754 – 816DisorderedSequence analysisAdd BLAST63
Regioni1041 – 1120DisorderedSequence analysisAdd BLAST80
Regioni1205 – 1290DisorderedSequence analysisAdd BLAST86
Regioni1342 – 1372DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 76PolarSequence analysisAdd BLAST27
Compositional biasi99 – 126PolarSequence analysisAdd BLAST28
Compositional biasi135 – 155PolarSequence analysisAdd BLAST21
Compositional biasi220 – 267PolarSequence analysisAdd BLAST48
Compositional biasi300 – 326PolarSequence analysisAdd BLAST27
Compositional biasi338 – 361PolarSequence analysisAdd BLAST24
Compositional biasi362 – 381PolyampholyteSequence analysisAdd BLAST20
Compositional biasi385 – 405PolarSequence analysisAdd BLAST21
Compositional biasi411 – 452PolyampholyteSequence analysisAdd BLAST42
Compositional biasi455 – 470PolarSequence analysisAdd BLAST16
Compositional biasi754 – 807PolarSequence analysisAdd BLAST54
Compositional biasi1043 – 1075PolarSequence analysisAdd BLAST33
Compositional biasi1076 – 1114AcidicSequence analysisAdd BLAST39
Compositional biasi1261 – 1286PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1349 – 1363PolarSequence analysisAdd BLAST15

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156524

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010306

Database of Orthologous Groups

More...
OrthoDBi
180681at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329009

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041697 Znf-C2H2_11
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 2 hits
PF16622 zf-C2H2_11, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q1L8S9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDMKTPDFD DLLAAFDIPD IDAKEAIQSA PDEVEGHQGA GGASLIKSGD
60 70 80 90 100
ASVGESSALR SPSPSTDSQS DPSIVSVIVK NRVRPEPFDG GENSVPDPLN
110 120 130 140 150
HNGFVSSGGS VHMSQSRGQP NGEQWPVCSS KAIPETAGQH GSSGGSKQGS
160 170 180 190 200
NIFNKLKPLM AQGAGDSVGR ARKMQLLQQQ HMQQEMNLEG ADKAKAPANP
210 220 230 240 250
SGASGAASPF FPPPKPLLST PSTASSSSPS SSSPSVGSRV SGAVASSPLA
260 270 280 290 300
TSLTEPFNGT PRLSSSAFRR ADSEEEDSDP DSGGSLVIHE SPDSPTPPKL
310 320 330 340 350
SRRLRSSPEN SQSPSIPPST SISPNAYPKP GDVPSASPAS PRAQQNWLST
360 370 380 390 400
AAQTGNGKSL PQEERNPEHV IEERDSPESP EPEMPKSSMP TSAVTKRSCS
410 420 430 440 450
PAAASSPSAA LREPKEEDEE MEVDKASTEN GQDAENTDGG KGDTDKIEVD
460 470 480 490 500
PAQSLEAETG SSTNSDGKAA TGGKAPSRPL KVRIKTIKTS TGGITRTVTR
510 520 530 540 550
VAGKGGAAAN AGKDANKGQT GGRAGPVKGG KKNDTTAGQG VKCSTLPVST
560 570 580 590 600
LEASSAMLAA ASKVQNKMTM QSDKTKVSAT AVSITKATTL PVAPAVGGIS
610 620 630 640 650
VRPTVGKTTN GGTMPCKPAS IVNSTGAVIS RSQSSLVEAF NKILNSKNLL
660 670 680 690 700
PSYRPDLSTP PPPEWGLPMP AAGYRCLECG DSFALERSLA RHYDRRSLRI
710 720 730 740 750
EVTCNHCAKR LAFFNKCSLL LHAREHKERG LVMQCSHLVM RPVTVEQMIG
760 770 780 790 800
QQDTTPIGML SPSLSSPPLT SSTTPAGTIP APSTSSPLKD SPSPGTASTQ
810 820 830 840 850
PSPARRGPQS PQALMPLPCK KGEALQYHNF KCPECQAQFL SKAELVTHFQ
860 870 880 890 900
QIRATPNSTC TLCSPPMMLP NWCSVSAHQR IHKHRAPHVC PECGGTARQA
910 920 930 940 950
TFQTHLEESC LHFARRIGYR CSSCQVVFGG LNSIKSHIQT AHCEVFHKCP
960 970 980 990 1000
NCPMAFKSAQ SAQGHITSQH PALTAAQAKM IYKCVMCDTV FTQKPLLYMH
1010 1020 1030 1040 1050
FDTHLAKQKV HVFKCPDCTK LYAQKGSMME HIKTAHRGLS VKAETPPTTS
1060 1070 1080 1090 1100
SPVSAPAGNS TSKPKPATEN NSDELSQGPG EEEEEGEDEE GEQEGEERED
1110 1120 1130 1140 1150
EEEEENEEEE QVSSPESGNM EWRCKECKKR FPEREDYIDH MKNEHGTVMK
1160 1170 1180 1190 1200
KFPCRLCERS FSSANSLRRH VRIIHEGVKR VFHCPHCSEG KRTFSSRLIL
1210 1220 1230 1240 1250
EKHIRVRHGI RSRQTTDRTN APNTRKRSLP ADGAGSSSEL DNESGAPPAG
1260 1270 1280 1290 1300
GGTDTDDVPG EDTSGPAKRT RASENRPVEQ EEEDGTFRCT PCGFTTQDWE
1310 1320 1330 1340 1350
EFQRHIPVHC DAENAPQQCL QCGACFASAG SLSRHKFITH RLRQGQHDRN
1360 1370 1380 1390 1400
ASPGASPQYG SPSSPKAGED GDGGVSCRVC GRRFDKASDL NTHFRTHGMA
1410
FITAHRTDKP L
Length:1,411
Mass (Da):150,639
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6DD48EDD6DCD435C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6NSX9Z687B_DANRE
Zinc finger protein 687b
znf687b si:dkey-204a24.9
1,431Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR628394 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001334602.1, NM_001347673.1
XP_001340736.2, XM_001340700.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000104703; ENSDARP00000095474; ENSDARG00000019299

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100006039

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:100006039

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628394 Genomic DNA No translation available.
RefSeqiNP_001334602.1, NM_001347673.1
XP_001340736.2, XM_001340700.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000104703; ENSDARP00000095474; ENSDARG00000019299
GeneIDi100006039
KEGGidre:100006039

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100006039
ZFINiZDB-GENE-041111-214 znf687b

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000156524
HOGENOMiHOG000010306
OrthoDBi180681at2759
TreeFamiTF329009

Gene expression databases

BgeeiENSDARG00000019299 Expressed in 18 organ(s), highest expression level in mature ovarian follicle
ExpressionAtlasiQ1L8S9 baseline

Family and domain databases

InterProiView protein in InterPro
IPR041697 Znf-C2H2_11
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
PF16622 zf-C2H2_11, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ1L8S9_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1L8S9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: January 20, 2016
Last modified: June 5, 2019
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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