UniProtKB - Q1L8M6 (Q1L8M6_DANRE)
Protein
Submitted name:
Cyclin D2, b
Gene
ccnd2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- mitotic cell cycle phase transition Source: GO_Central
- positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Keywordsi
Molecular function | CyclinUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-DRE-5687128, MAPK6/MAPK4 signaling R-DRE-69231, Cyclin D associated events in G1 R-DRE-8934593, Regulation of RUNX1 Expression and Activity |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclin D2, bImportedSubmitted name: Cyclin D2BImported |
Gene namesi | Name:ccnd2bImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-050420-354, ccnd2b |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSDARG00000070408, Expressed in swim bladder and 22 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 87 | Cyclin N-terminalInterPro annotationAdd BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 260 – 295 | DisorderedSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the cyclin family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155180 |
HOGENOMi | CLU_052190_0_0_1 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF66, PTHR10177:SF66, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q1L8M6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELFCLEKDT VVRAQKDPNI FCDERVLQSL LTVEDRYVPQ GPYFKCVQKD
60 70 80 90 100
IQPFMRKMVA TWMLEVCEEE KCEDDVFPLA MNYLDRFLAA VPTRKCYLQL
110 120 130 140 150
LGAVCLFLAS KLKACQPLSA RKLCMYTDNS ITSQQLLWEL VVLSKLKWNL
160 170 180 190 200
AAITPLDFIE HILHKLPFHE DRLTLIRKHT QTFIALCATD HSFTMYPPSM
210 220 230 240 250
IATGCVGAAV CGLQSSQSNQ SLWGDNLMEL LAKITNTELD CLKSCQEQIE
260 270 280 290
QLLTDSLKES QQQHQQQQQD GRASNKGTQS QNLSCTPTDV RDVNL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR751235 Genomic DNA No translation available. FJ648074 mRNA Translation: ACV41907.1 |
RefSeqi | NP_001038533.1, NM_001045068.1 |
Genome annotation databases
Ensembli | ENSDART00000103279; ENSDARP00000094056; ENSDARG00000070408 |
GeneIDi | 565038 |
KEGGi | dre:565038 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR751235 Genomic DNA No translation available. FJ648074 mRNA Translation: ACV41907.1 |
RefSeqi | NP_001038533.1, NM_001045068.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000103279; ENSDARP00000094056; ENSDARG00000070408 |
GeneIDi | 565038 |
KEGGi | dre:565038 |
Organism-specific databases
CTDi | 565038 |
ZFINi | ZDB-GENE-050420-354, ccnd2b |
Phylogenomic databases
GeneTreei | ENSGT00940000155180 |
HOGENOMi | CLU_052190_0_0_1 |
Enzyme and pathway databases
Reactomei | R-DRE-5687128, MAPK6/MAPK4 signaling R-DRE-69231, Cyclin D associated events in G1 R-DRE-8934593, Regulation of RUNX1 Expression and Activity |
Gene expression databases
Bgeei | ENSDARG00000070408, Expressed in swim bladder and 22 other tissues |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF66, PTHR10177:SF66, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q1L8M6_DANRE | |
Accessioni | Q1L8M6Primary (citable) accession number: Q1L8M6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 30, 2006 |
Last sequence update: | May 30, 2006 | |
Last modified: | April 7, 2021 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |