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UniProtKB - Q1L658 (FA102_PSETE)
Protein
Coagulation factor X isoform 2
Gene
F10
Organism
Pseudonaja textilis (Eastern brown snake)
Status
Functioni
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
By similarityCatalytic activityi
- Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. EC:3.4.21.6
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 251 | Charge relay systemBy similarity | 1 | |
Active sitei | 305 | Charge relay systemBy similarity | 1 | |
Active sitei | 402 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- serine-type endopeptidase activity Source: UniProtKB-EC
GO - Biological processi
- blood coagulation Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium |
Protein family/group databases
MEROPSi | S01.446 |
Names & Taxonomyi
Protein namesi | Recommended name: Coagulation factor X isoform 2 (EC:3.4.21.6)Short name: PFX2 Cleaved into the following 3 chains: |
Gene namesi | Name:F10 |
Organismi | Pseudonaja textilis (Eastern brown snake) |
Taxonomic identifieri | 8673 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Acanthophiinae › Pseudonaja |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000409920 | 21 – 40 | By similarityAdd BLAST | 20 | |
ChainiPRO_0000409921 | 41 – 463 | Coagulation factor X isoform 2Add BLAST | 423 | |
ChainiPRO_0000409922 | 41 – 180 | Factor X light chainAdd BLAST | 140 | |
ChainiPRO_0000409923 | 183 – 463 | Factor X heavy chainAdd BLAST | 281 | |
PropeptideiPRO_0000409924 | 183 – 209 | Activation peptideBy similarityAdd BLAST | 27 | |
ChainiPRO_0000409925 | 210 – 463 | Activated factor Xa heavy chainAdd BLAST | 254 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 46 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 47 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 54 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 56 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 57 ↔ 62 | By similarity | ||
Modified residuei | 59 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 60 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 65 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 66 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 69 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 72 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Modified residuei | 75 | 4-carboxyglutamatePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 90 ↔ 101 | By similarity | ||
Glycosylationi | 92 | O-linked (Hex...) serineBy similarity | 1 | |
Disulfide bondi | 95 ↔ 110 | By similarity | ||
Modified residuei | 103 | (3R)-3-hydroxyaspartateBy similarity | 1 | |
Disulfide bondi | 112 ↔ 121 | By similarity | ||
Disulfide bondi | 129 ↔ 140 | By similarity | ||
Disulfide bondi | 136 ↔ 149 | By similarity | ||
Disulfide bondi | 151 ↔ 164 | By similarity | ||
Disulfide bondi | 172 ↔ 325 | Interchain (between light and heavy chains)PROSITE-ProRule annotation | ||
Disulfide bondi | 216 ↔ 221 | By similarity | ||
Disulfide bondi | 236 ↔ 252 | By similarity | ||
Glycosylationi | 254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 373 ↔ 387 | By similarity | ||
Disulfide bondi | 398 ↔ 426 | By similarity |
Post-translational modificationi
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).By similarity
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, ZymogenExpressioni
Tissue specificityi
Interactioni
Subunit structurei
Heterodimer of a light chain and a heavy chain; disulfide-linked.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 86 | GlaPROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 86 – 122 | EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 125 – 165 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 210 – 450 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 241 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalFamily and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 1 hit 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 2 hits PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q1L658-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPQLLLCLI LTFLWSLPEA ESNVFLKSKV ANRFLQRTKR ANSLVEEFKS
60 70 80 90 100
GNIERECIEE RCSKEEAREA FEDDEKTETF WNVYVDGDQC SSNPCHYRGI
110 120 130 140 150
CKDGIGSYTC TCLSGYEGKN CERVLYKSCR VDNGNCWHFC KHVQNDIQCS
160 170 180 190 200
CAEGYLLGED GHSCVAGGNF SCGRNIKTRN KREANLPDFV QSQNATLLKK
210 220 230 240 250
SDNPSPDIRI VNGMDCKLGE CPWQAALVDE KEGVFCGGTI LSPIYVLTAA
260 270 280 290 300
HCINETETIS VVVGEIDKSR IETGPLLSVD KIYVHKKFVP PQKAYKFDLA
310 320 330 340 350
AYDYDIAIIQ MKTPIQFSEN VVPACLPTAD FANQVLMKQD FGIVSGFGRI
360 370 380 390 400
FEKGPKSKTL KVLKVPYVDR HTCMVSSETP ITPNMFCAGY DTLPRDACQG
410 420 430 440 450
DSGGPHTTVY RDTHFITGIV SSGEGCARNG KYGIYTKLSK FIPWIKRIMR
460
QKLPSTESST GRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ017706 mRNA Translation: AAY85308.1 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Factor X entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ017706 mRNA Translation: AAY85308.1 |
3D structure databases
SMRi | Q1L658 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | S01.446 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 1 hit 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 2 hits PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FA102_PSETE | |
Accessioni | Q1L658Primary (citable) accession number: Q1L658 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 28, 2011 |
Last sequence update: | May 30, 2006 | |
Last modified: | June 2, 2021 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families