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UniProtKB - Q1L5Z9 (LONF2_HUMAN)

Entry version 128 (07 Apr 2021)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

LON peptidase N-terminal domain and RING finger protein 2

Gene

LONRF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri449 – 487RING-typePROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q1L5Z9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LON peptidase N-terminal domain and RING finger protein 2
Alternative name(s):
Neuroblastoma apoptosis-related protease
RING finger protein 192
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LONRF2
Synonyms:RNF192
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24788, LONRF2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q1L5Z9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170500.12

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		164832

Open Targets

More...OpenTargetsi		ENSG00000170500

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671540

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q1L5Z9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LONRF2

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104224

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002776701 – 754LON peptidase N-terminal domain and RING finger protein 2Add BLAST754

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q1L5Z9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q1L5Z9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q1L5Z9

PeptideAtlas

More...PeptideAtlasi		Q1L5Z9

PRoteomics IDEntifications database

More...PRIDEi		Q1L5Z9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61220 [Q1L5Z9-1]
61221 [Q1L5Z9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q1L5Z9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q1L5Z9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170500, Expressed in caput epididymis and 191 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q1L5Z9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170500, Tissue enhanced (brain, epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127903, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q1L5Z9, 28 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377086

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q1L5Z9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q1L5Z9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 58TPR 1Add BLAST36
Repeati59 – 91TPR 2Add BLAST33
Repeati197 – 230TPR 3Add BLAST34
Repeati231 – 264TPR 4Add BLAST34
Repeati266 – 298TPR 5Add BLAST33
Repeati447 – 483TPR 6Add BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini535 – 735Lon N-terminalPROSITE-ProRule annotationAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 12Poly-Pro10

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri449 – 487RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0508, Eukaryota
KOG1124, Eukaryota
KOG4159, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00440000033329

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013989_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q1L5Z9

Identification of Orthologs from Complete Genome Data

More...OMAi		LFYEPVA

Database of Orthologous Groups

More...OrthoDBi		458276at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q1L5Z9

TreeFam database of animal gene trees

More...TreeFami		TF327043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003111, Lon_substr-bd
IPR015947, PUA-like_sf
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR027370, Znf-RING_LisH
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02190, LON_substr_bdg, 1 hit
PF13445, zf-RING_UBOX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00464, LON, 1 hit
SM00184, RING, 2 hits
SM00028, TPR, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit
SSF88697, SSF88697, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51787, LON_N, 1 hit
PS50293, TPR_REGION, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q1L5Z9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML 
        60         70         80         90        100
AGLAQPDRGL CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG 
       110        120        130        140        150
GLVRAVGLRD RPLSAENPGG EPEAPGEGGP APEPRAPRDL LGCPRCRRLL 
       160        170        180        190        200
HKPVTLPCGL TVCKRCVEPG PARPQVRRVN VVLSGLLEKC FPAECRLRRL 
       210        220        230        240        250
AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL YLTMKNYEQA 
       260        270        280        290        300
LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS 
       310        320        330        340        350
VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD 
       360        370        380        390        400
AGSSENSSEK SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK 
       410        420        430        440        450
RQFPDDVEDA PDLNAPGKIP KKDLSLQRSP NSETEESQGL SLDVTDFECA 
       460        470        480        490        500
LCMRLLFEPV TTPCGHTFCL KCLERCLDHA PHCPLCKDKL SELLASRNFN 
       510        520        530        540        550
ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI FVCAMAFPTV 
       560        570        580        590        600
PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR 
       610        620        630        640        650
TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA 
       660        670        680        690        700
ALHDSVHQQS VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW 
       710        720        730        740        750
WILAVLPLER KAQLAILGMT SLKERLLAIR RILVIITRKM NSRQELANAR 

ERNN
Length:754
Mass (Da):83,654
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i688EE74DCF7893D3
GO
Isoform 2 (identifier: Q1L5Z9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.

Show »
Length:511
Mass (Da):57,487
Checksum:iAE7D01250CE317F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti648E → Q in AAY84832 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030590183L → P. Corresponds to variant dbSNP:rs4851287Ensembl.1
Natural variantiVAR_054639426L → P3 PublicationsCorresponds to variant dbSNP:rs4851287Ensembl.1
Natural variantiVAR_035953562R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs773205136Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0230791 – 243Missing in isoform 2. 2 PublicationsAdd BLAST243

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ020495 mRNA Translation: AAY84832.1
AK127206 mRNA Translation: BAC86883.1
AC104782 Genomic DNA No translation available.
AC012493 Genomic DNA No translation available.
BC101664 mRNA Translation: AAI01665.1
BC101662 mRNA Translation: AAI01663.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2046.2 [Q1L5Z9-1]

NCBI Reference Sequences

More...RefSeqi		NP_940863.3, NM_198461.3 [Q1L5Z9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000393437; ENSP00000377086; ENSG00000170500 [Q1L5Z9-1]
ENST00000409647; ENSP00000386823; ENSG00000170500 [Q1L5Z9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		164832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:164832

UCSC genome browser

More...UCSCi		uc002tal.4, human [Q1L5Z9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ020495 mRNA Translation: AAY84832.1
AK127206 mRNA Translation: BAC86883.1
AC104782 Genomic DNA No translation available.
AC012493 Genomic DNA No translation available.
BC101664 mRNA Translation: AAI01665.1
BC101662 mRNA Translation: AAI01663.1
CCDSiCCDS2046.2 [Q1L5Z9-1]
RefSeqiNP_940863.3, NM_198461.3 [Q1L5Z9-1]

3D structure databases

SMRiQ1L5Z9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127903, 16 interactors
IntActiQ1L5Z9, 28 interactors
STRINGi9606.ENSP00000377086

PTM databases

iPTMnetiQ1L5Z9
PhosphoSitePlusiQ1L5Z9

Genetic variation databases

BioMutaiLONRF2
DMDMi313104224

Proteomic databases

MassIVEiQ1L5Z9
MaxQBiQ1L5Z9
PaxDbiQ1L5Z9
PeptideAtlasiQ1L5Z9
PRIDEiQ1L5Z9
ProteomicsDBi61220 [Q1L5Z9-1]
61221 [Q1L5Z9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32852, 90 antibodies

Genome annotation databases

EnsembliENST00000393437; ENSP00000377086; ENSG00000170500 [Q1L5Z9-1]
ENST00000409647; ENSP00000386823; ENSG00000170500 [Q1L5Z9-2]
GeneIDi164832
KEGGihsa:164832
UCSCiuc002tal.4, human [Q1L5Z9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		164832
DisGeNETi164832

GeneCards: human genes, protein and diseases

More...GeneCardsi		LONRF2
HGNCiHGNC:24788, LONRF2
HPAiENSG00000170500, Tissue enhanced (brain, epididymis)
neXtProtiNX_Q1L5Z9
OpenTargetsiENSG00000170500
PharmGKBiPA142671540
VEuPathDBiHostDB:ENSG00000170500.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0508, Eukaryota
KOG1124, Eukaryota
KOG4159, Eukaryota
GeneTreeiENSGT00440000033329
HOGENOMiCLU_013989_1_2_1
InParanoidiQ1L5Z9
OMAiLFYEPVA
OrthoDBi458276at2759
PhylomeDBiQ1L5Z9
TreeFamiTF327043

Enzyme and pathway databases

PathwayCommonsiQ1L5Z9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		164832, 5 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LONRF2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		164832
PharosiQ1L5Z9, Tdark

Protein Ontology

More...PROi		PR:Q1L5Z9
RNActiQ1L5Z9, protein

Gene expression databases

BgeeiENSG00000170500, Expressed in caput epididymis and 191 other tissues
GenevisibleiQ1L5Z9, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR003111, Lon_substr-bd
IPR015947, PUA-like_sf
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR027370, Znf-RING_LisH
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF02190, LON_substr_bdg, 1 hit
PF13445, zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00464, LON, 1 hit
SM00184, RING, 2 hits
SM00028, TPR, 3 hits
SUPFAMiSSF48452, SSF48452, 1 hit
SSF88697, SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS51787, LON_N, 1 hit
PS50293, TPR_REGION, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLONF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1L5Z9
Secondary accession number(s): B9A006, Q6ZSR4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 30, 2010
Last modified: April 7, 2021
This is version 128 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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