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UniProtKB - Q1L5Z9 (LONF2_HUMAN)
Protein
LON peptidase N-terminal domain and RING finger protein 2
Gene
LONRF2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 449 – 487 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q1L5Z9 |
SignaLinki | Q1L5Z9 |
Names & Taxonomyi
Protein namesi | Recommended name: LON peptidase N-terminal domain and RING finger protein 2Alternative name(s): Neuroblastoma apoptosis-related protease RING finger protein 192 |
Gene namesi | Name:LONRF2 Synonyms:RNF192 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24788, LONRF2 |
neXtProti | NX_Q1L5Z9 |
VEuPathDBi | HostDB:ENSG00000170500 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 164832 |
OpenTargetsi | ENSG00000170500 |
PharmGKBi | PA142671540 |
Miscellaneous databases
Pharosi | Q1L5Z9, Tdark |
Genetic variation databases
BioMutai | LONRF2 |
DMDMi | 313104224 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000277670 | 1 – 754 | LON peptidase N-terminal domain and RING finger protein 2Add BLAST | 754 |
Proteomic databases
MassIVEi | Q1L5Z9 |
MaxQBi | Q1L5Z9 |
PaxDbi | Q1L5Z9 |
PeptideAtlasi | Q1L5Z9 |
PRIDEi | Q1L5Z9 |
ProteomicsDBi | 61220 [Q1L5Z9-1] 61221 [Q1L5Z9-2] |
PTM databases
iPTMneti | Q1L5Z9 |
PhosphoSitePlusi | Q1L5Z9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170500, Expressed in caput epididymis and 192 other tissues |
Genevisiblei | Q1L5Z9, HS |
Organism-specific databases
HPAi | ENSG00000170500, Tissue enhanced (brain, fallopian tube) |
Interactioni
Binary interactionsi
Q1L5Z9
Protein-protein interaction databases
BioGRIDi | 127903, 20 interactors |
IntActi | Q1L5Z9, 28 interactors |
STRINGi | 9606.ENSP00000377086 |
Miscellaneous databases
RNActi | Q1L5Z9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 23 – 58 | TPR 1Add BLAST | 36 | |
Repeati | 59 – 91 | TPR 2Add BLAST | 33 | |
Repeati | 197 – 230 | TPR 3Add BLAST | 34 | |
Repeati | 231 – 264 | TPR 4Add BLAST | 34 | |
Repeati | 266 – 298 | TPR 5Add BLAST | 33 | |
Repeati | 447 – 483 | TPR 6Add BLAST | 37 | |
Domaini | 535 – 735 | Lon N-terminalPROSITE-ProRule annotationAdd BLAST | 201 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 112 – 136 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 398 – 439 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 402 – 416 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 425 – 439 | Polar residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 449 – 487 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 |
Keywords - Domaini
Repeat, TPR repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0508, Eukaryota KOG1124, Eukaryota KOG4159, Eukaryota |
GeneTreei | ENSGT00440000033329 |
HOGENOMi | CLU_013989_1_2_1 |
InParanoidi | Q1L5Z9 |
OMAi | DVFRNTN |
OrthoDBi | 458276at2759 |
PhylomeDBi | Q1L5Z9 |
TreeFami | TF327043 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits 2.30.130.40, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR003111, Lon_prtase_N IPR046336, Lon_prtase_N_sf IPR015947, PUA-like_sf IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR027370, Znf-RING_LisH IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF02190, LON_substr_bdg, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00464, LON, 1 hit SM00184, RING, 2 hits SM00028, TPR, 3 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit SSF88697, SSF88697, 1 hit |
PROSITEi | View protein in PROSITE PS51787, LON_N, 1 hit PS50293, TPR_REGION, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q1L5Z9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML
60 70 80 90 100
AGLAQPDRGL CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG
110 120 130 140 150
GLVRAVGLRD RPLSAENPGG EPEAPGEGGP APEPRAPRDL LGCPRCRRLL
160 170 180 190 200
HKPVTLPCGL TVCKRCVEPG PARPQVRRVN VVLSGLLEKC FPAECRLRRL
210 220 230 240 250
AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL YLTMKNYEQA
260 270 280 290 300
LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS
310 320 330 340 350
VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD
360 370 380 390 400
AGSSENSSEK SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK
410 420 430 440 450
RQFPDDVEDA PDLNAPGKIP KKDLSLQRSP NSETEESQGL SLDVTDFECA
460 470 480 490 500
LCMRLLFEPV TTPCGHTFCL KCLERCLDHA PHCPLCKDKL SELLASRNFN
510 520 530 540 550
ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI FVCAMAFPTV
560 570 580 590 600
PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR
610 620 630 640 650
TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA
660 670 680 690 700
ALHDSVHQQS VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW
710 720 730 740 750
WILAVLPLER KAQLAILGMT SLKERLLAIR RILVIITRKM NSRQELANAR
ERNN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 648 | E → Q in AAY84832 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030590 | 183 | L → P. Corresponds to variant dbSNP:rs4851287Ensembl. | 1 | |
Natural variantiVAR_054639 | 426 | L → P3 PublicationsCorresponds to variant dbSNP:rs4851287Ensembl. | 1 | |
Natural variantiVAR_035953 | 562 | R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs773205136Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023079 | 1 – 243 | Missing in isoform 2. 2 PublicationsAdd BLAST | 243 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ020495 mRNA Translation: AAY84832.1 AK127206 mRNA Translation: BAC86883.1 AC104782 Genomic DNA No translation available. AC012493 Genomic DNA No translation available. BC101664 mRNA Translation: AAI01665.1 BC101662 mRNA Translation: AAI01663.1 |
CCDSi | CCDS2046.2 [Q1L5Z9-1] |
RefSeqi | NP_940863.3, NM_198461.3 [Q1L5Z9-1] |
Genome annotation databases
Ensembli | ENST00000393437.8; ENSP00000377086.3; ENSG00000170500.13 ENST00000409647.1; ENSP00000386823.1; ENSG00000170500.13 [Q1L5Z9-2] |
GeneIDi | 164832 |
KEGGi | hsa:164832 |
MANE-Selecti | ENST00000393437.8; ENSP00000377086.3; NM_198461.4; NP_940863.3 |
UCSCi | uc002tal.4, human [Q1L5Z9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ020495 mRNA Translation: AAY84832.1 AK127206 mRNA Translation: BAC86883.1 AC104782 Genomic DNA No translation available. AC012493 Genomic DNA No translation available. BC101664 mRNA Translation: AAI01665.1 BC101662 mRNA Translation: AAI01663.1 |
CCDSi | CCDS2046.2 [Q1L5Z9-1] |
RefSeqi | NP_940863.3, NM_198461.3 [Q1L5Z9-1] |
3D structure databases
AlphaFoldDBi | Q1L5Z9 |
SMRi | Q1L5Z9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127903, 20 interactors |
IntActi | Q1L5Z9, 28 interactors |
STRINGi | 9606.ENSP00000377086 |
PTM databases
iPTMneti | Q1L5Z9 |
PhosphoSitePlusi | Q1L5Z9 |
Genetic variation databases
BioMutai | LONRF2 |
DMDMi | 313104224 |
Proteomic databases
MassIVEi | Q1L5Z9 |
MaxQBi | Q1L5Z9 |
PaxDbi | Q1L5Z9 |
PeptideAtlasi | Q1L5Z9 |
PRIDEi | Q1L5Z9 |
ProteomicsDBi | 61220 [Q1L5Z9-1] 61221 [Q1L5Z9-2] |
Protocols and materials databases
Antibodypediai | 32852, 91 antibodies from 18 providers |
DNASUi | 164832 |
Genome annotation databases
Ensembli | ENST00000393437.8; ENSP00000377086.3; ENSG00000170500.13 ENST00000409647.1; ENSP00000386823.1; ENSG00000170500.13 [Q1L5Z9-2] |
GeneIDi | 164832 |
KEGGi | hsa:164832 |
MANE-Selecti | ENST00000393437.8; ENSP00000377086.3; NM_198461.4; NP_940863.3 |
UCSCi | uc002tal.4, human [Q1L5Z9-1] |
Organism-specific databases
CTDi | 164832 |
DisGeNETi | 164832 |
GeneCardsi | LONRF2 |
HGNCi | HGNC:24788, LONRF2 |
HPAi | ENSG00000170500, Tissue enhanced (brain, fallopian tube) |
neXtProti | NX_Q1L5Z9 |
OpenTargetsi | ENSG00000170500 |
PharmGKBi | PA142671540 |
VEuPathDBi | HostDB:ENSG00000170500 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0508, Eukaryota KOG1124, Eukaryota KOG4159, Eukaryota |
GeneTreei | ENSGT00440000033329 |
HOGENOMi | CLU_013989_1_2_1 |
InParanoidi | Q1L5Z9 |
OMAi | DVFRNTN |
OrthoDBi | 458276at2759 |
PhylomeDBi | Q1L5Z9 |
TreeFami | TF327043 |
Enzyme and pathway databases
PathwayCommonsi | Q1L5Z9 |
SignaLinki | Q1L5Z9 |
Miscellaneous databases
BioGRID-ORCSi | 164832, 15 hits in 1113 CRISPR screens |
ChiTaRSi | LONRF2, human |
GenomeRNAii | 164832 |
Pharosi | Q1L5Z9, Tdark |
PROi | PR:Q1L5Z9 |
RNActi | Q1L5Z9, protein |
Gene expression databases
Bgeei | ENSG00000170500, Expressed in caput epididymis and 192 other tissues |
Genevisiblei | Q1L5Z9, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits 2.30.130.40, 1 hit 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR003111, Lon_prtase_N IPR046336, Lon_prtase_N_sf IPR015947, PUA-like_sf IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR027370, Znf-RING_LisH IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF02190, LON_substr_bdg, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00464, LON, 1 hit SM00184, RING, 2 hits SM00028, TPR, 3 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit SSF88697, SSF88697, 1 hit |
PROSITEi | View protein in PROSITE PS51787, LON_N, 1 hit PS50293, TPR_REGION, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LONF2_HUMAN | |
Accessioni | Q1L5Z9Primary (citable) accession number: Q1L5Z9 Secondary accession number(s): B9A006, Q6ZSR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | November 30, 2010 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports