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UniProtKB - Q1K8F6 (NAGS_NEUCR)
Protein
Amino-acid acetyltransferase, mitochondrial
Gene
arg-14
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Functioni
N-acetylglutamate synthase involved in arginine biosynthesis.
2 PublicationsCatalytic activityi
- EC:2.3.1.1
Activity regulationi
Inhibited by arginine.1 Publication
Kineticsi
- KM=6.3 nM for glutamate1 Publication
pH dependencei
Optimum pH is 8.8-9.1 Publication
: L-arginine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate. This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- acetyl-CoA:L-glutamate N-acetyltransferase activity Source: GO_Central
- arginine binding Source: GO_Central
- methione N-acyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- arginine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Amino-acid biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00106 |
Names & Taxonomyi
Protein namesi | Recommended name: Amino-acid acetyltransferase, mitochondrial (EC:2.3.1.1)Alternative name(s): Arginine-requiring protein 14 Glutamate N-acetyltransferase N-acetylglutamate synthase Short name: AGS Short name: NAGS |
Gene namesi | Name:arg-14 ORF Names:NCU07682 |
Organismi | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic identifieri | 367110 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:NCU07682 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrial matrix Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 47 | MitochondrionSequence analysisAdd BLAST | 47 | |
ChainiPRO_0000372569 | 48 – 712 | Amino-acid acetyltransferase, mitochondrialAdd BLAST | 665 |
Expressioni
Inductioni
By histidine or arginine limitation.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 534 – 702 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 169 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 55 – 99 | DisorderedSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the acetyltransferase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
HOGENOMi | CLU_013088_0_0_1 |
InParanoidi | Q1K8F6 |
Family and domain databases
InterProi | View protein in InterPro IPR011190, GlcNAc_Synth_fun IPR006855, Vertebrate-like_GNAT_dom |
Pfami | View protein in Pfam PF04768, NAT, 1 hit |
PIRSFi | PIRSF007892, NAGS_fungal, 1 hit |
PROSITEi | View protein in PROSITE PS51731, GNAT_NAGS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q1K8F6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFVRTCRSSC NAWTNATSTT QAGSLLPPNA HRSVVLTLSL QACSARTHES
60 70 80 90 100
LIRSFASTTS QSKRQEAEAE EKRQVSPRLG PSAPRSSYPS SAEARQKRDS
110 120 130 140 150
DREFLISVLE SSATKRDARG YLQTFGSSAA LTSAGQKKPS TIGILGVPAS
160 170 180 190 200
VAGRPAFVQG TEKEISVKRN EAPHVAVVKL RAPQAWDDVL LEGVAKTLTR
210 220 230 240 250
LRDLGLLSVI VLDCDDIKPN QASSWHETVT EQTDRLLRAI GQYGFPAAEV
260 270 280 290 300
VDSGIWKSTE NPQIPSSVPS NPLYVGFGKA FTTPLANGHI LVVPPRAYSD
310 320 330 340 350
ASLQYSKADA NDIVIALTTF FAGLQFGQQS SDYRQLAEKV SDGQSFRKAL
360 370 380 390 400
VDRVIVIDPL GGIPSHRQGH GTQVFINLED EFKNIQDALY EKTQPTSAGT
410 420 430 440 450
KDAGVSARAT VHLENLRLAK STLALLPSNA SVVMTSPAEA ANINVSRRNQ
460 470 480 490 500
LEAKPDGFAG EVKTRTWRNP LIHNLLTDRP IYSSSLPIGR IKPTHQDEEI
510 520 530 540 550
ALSRMPTTTL AKRGLPVTIF PDPRVNRWQP PQPGVPRLRL TDTCIDLPRL
560 570 580 590 600
VHLINDSFGR KLNVEHYLDR VKDSLAGIII AGEYEGGAIL TWETPFGLDE
610 620 630 640 650
ETAYRKGRLV PYLDKFAVLR KSQGAGGVAD IVFNAMVRDA FPDGVCWRSR
660 670 680 690 700
KDNPVNKWYF ERSRGVLKLP ESNWAMFWTT PEAVSNDQMM RDYEDVCRNI
710
APSWADTTKP AD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketV5INB8 | V5INB8_NEUCR | Amino-acid acetyltransferase, mitoc... | arg-14 NCU07682 | 692 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35484 Genomic DNA Translation: AAC37502.1 CM002239 Genomic DNA Translation: ESA42856.1 |
RefSeqi | XP_011394254.1, XM_011395952.1 |
Genome annotation databases
EnsemblFungii | ESA42856; ESA42856; NCU07682 |
GeneIDi | 3878463 |
KEGGi | ncr:NCU07682 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35484 Genomic DNA Translation: AAC37502.1 CM002239 Genomic DNA Translation: ESA42856.1 |
RefSeqi | XP_011394254.1, XM_011395952.1 |
3D structure databases
SMRi | Q1K8F6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5141.EFNCRP00000007999 |
Genome annotation databases
EnsemblFungii | ESA42856; ESA42856; NCU07682 |
GeneIDi | 3878463 |
KEGGi | ncr:NCU07682 |
Organism-specific databases
VEuPathDBi | FungiDB:NCU07682 |
Phylogenomic databases
HOGENOMi | CLU_013088_0_0_1 |
InParanoidi | Q1K8F6 |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00106 |
Family and domain databases
InterProi | View protein in InterPro IPR011190, GlcNAc_Synth_fun IPR006855, Vertebrate-like_GNAT_dom |
Pfami | View protein in Pfam PF04768, NAT, 1 hit |
PIRSFi | PIRSF007892, NAGS_fungal, 1 hit |
PROSITEi | View protein in PROSITE PS51731, GNAT_NAGS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NAGS_NEUCR | |
Accessioni | Q1K8F6Primary (citable) accession number: Q1K8F6 Secondary accession number(s): Q12643, V5IQ12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | February 19, 2014 | |
Last modified: | February 23, 2022 | |
This is version 75 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families