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Entry version 70 (02 Jun 2021)
Sequence version 1 (13 Jun 2006)
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Protein
Submitted name:

Calpain-7, putative

Gene

TgIa.1460

Organism
Toxoplasma gondii
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1294PROSITE-ProRule annotation1
Active sitei1512PROSITE-ProRule annotation1
Active sitei1532PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.029

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calpain-7, putativeImported (EC:3.4.22.27Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TgIa.1460Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondiiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5811 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Ia

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGARI_293820
ToxoDB:TGCAST_293820
ToxoDB:TGCOUG_293820
ToxoDB:TGDOM2_293820
ToxoDB:TGFOU_293820
ToxoDB:TGGT1_293820
ToxoDB:TGMAS_293820
ToxoDB:TGME49_293820
ToxoDB:TGP89_293820
ToxoDB:TGPRC2_293820
ToxoDB:TGRH88_019110
ToxoDB:TGRUB_293820
ToxoDB:TGVAND_293820
ToxoDB:TGVEG_293820

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1247 – 1594Calpain catalyticInterPro annotationAdd BLAST348

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 131DisorderedSequence analysisAdd BLAST56
Regioni195 – 219DisorderedSequence analysisAdd BLAST25
Regioni405 – 444DisorderedSequence analysisAdd BLAST40
Regioni564 – 738DisorderedSequence analysisAdd BLAST175
Regioni764 – 970DisorderedSequence analysisAdd BLAST207
Regioni1102 – 1127DisorderedSequence analysisAdd BLAST26
Regioni1666 – 1690DisorderedSequence analysisAdd BLAST25
Regioni1768 – 1799DisorderedSequence analysisAdd BLAST32
Regioni2075 – 2101DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi76 – 96Polar residuesSequence analysisAdd BLAST21
Compositional biasi103 – 131Polar residuesSequence analysisAdd BLAST29
Compositional biasi199 – 214Polar residuesSequence analysisAdd BLAST16
Compositional biasi406 – 420Polar residuesSequence analysisAdd BLAST15
Compositional biasi564 – 601Polar residuesSequence analysisAdd BLAST38
Compositional biasi606 – 652Basic and acidic residuesSequence analysisAdd BLAST47
Compositional biasi683 – 708Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi769 – 790Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi791 – 815Polar residuesSequence analysisAdd BLAST25
Compositional biasi833 – 847Polar residuesSequence analysisAdd BLAST15
Compositional biasi937 – 970Polar residuesSequence analysisAdd BLAST34
Compositional biasi1105 – 1126Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1768 – 1791Basic and acidic residuesSequence analysisAdd BLAST24

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
PVELWIL

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00044, CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022684, Calpain_cysteine_protease
IPR036213, Calpain_III_sf
IPR038765, Papain-like_cys_pep_sf
IPR001300, Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00648, Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704, CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230, CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1JT76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGFASSFSL LPPTFPVSSA SACLEKKQAI YPPEGAAPGG ASFFAAFPSP
60 70 80 90 100
VFEVGTLSNF FSSLSPLSPL TSGDHFYSSS HSSPRSTPSS GNAVPSLHSV
110 120 130 140 150
PPAHAPSGSS QCTDSLPTAR GSCSSLQTKV PDTPQRRRCS LWTAAPSHVW
160 170 180 190 200
EERWRVDCQA GWERAIEESL DLRSEKEDTA LYREQTPPCI ETAVSAGCEG
210 220 230 240 250
HRRSNSSSPR GASPSVASDR PLASLCVGEE LSRAAASPIR APEASCSPSS
260 270 280 290 300
ICPSALPSTR EAGPLSPGVA REFSPSVARL RRHSRFRLQD ASGSQKGAAE
310 320 330 340 350
ARDARKLRGF FGTFLADGSG DTRVDPERDP SKPPRHLETR LFNPALRFLS
360 370 380 390 400
ERRIQASSSS CSVFLSSPSP FRGNYLERGV PDCGRDSSPA VVAFGTAPYT
410 420 430 440 450
RRLSPWSPLR SPNSASACAQ PPRRRNGIAA SSARAPSFSP SLSSHSSSLS
460 470 480 490 500
SYRSSVPSLS PSHVVSSRLS LSSVSSAFAR PFRRVLRRPE TWSPLPSEGC
510 520 530 540 550
PAWRLSPATP EDSLPLSGSL SAASAPSGVR LTASALSPER RPDSLGIASA
560 570 580 590 600
PPNCLRKMGC QCSTQRNVRR PESPSKSQSD SVVRRSEGTR AGLSSTPATV
610 620 630 640 650
EGTPREAKRQ GSRGSEARCE AADGEPRKRG GIRAREADEP GKEEEEVSAD
660 670 680 690 700
AASEKPVDGT PGGVSSPEGR AGQGTQEPGK KCGVRGDTSH ASREAGTWRL
710 720 730 740 750
EERENHQTEG SSPPLPWQSE QKDLERSGVG EGDAPPLFSR LASSGLTALE
760 770 780 790 800
KDVHAGHLEA MESRVALSAA GGRKRRGEEV KERGDSEAHP SEQETLMTSP
810 820 830 840 850
ARLASTGTTR ATESTREAPP AGPALGTCSG RGCPSPETAT SGPGKGSLRS
860 870 880 890 900
CASRDGSPAA IFSSPYKRRS SGRQGRGDEA GSAAPIAGAC SRPKDGKATP
910 920 930 940 950
GVASSSFASG DGCSDGGVDP DRGSAARRRD SSRSLVRRRV SSASPSRPEG
960 970 980 990 1000
PSSGRVSGSR PRHTQSGCSG IVSQGSAFPA ALSQWKKGAC VSNKCADSDA
1010 1020 1030 1040 1050
LCCLSPLAYS QQKLLPSHLS GSLAVSEILL ESSIVGRYVM LPWNEEDGDI
1060 1070 1080 1090 1100
RQNFYVHCPP PVALCSPLSQ SVAMHASTPP PFPLGPSRRE AVAACPVSPP
1110 1120 1130 1140 1150
CGRRGRVNRR SEPERGDGRG RDELESGMYA GAKLAPEGLV KKDGAVSSRF
1160 1170 1180 1190 1200
EGEARSHPCP RPPACCTSIP LASASSPTGG SSFAGASVSD PVVRTEAEGE
1210 1220 1230 1240 1250
VSPGELGVPG DSAEAPACDL ATLSPCGDPG ALGRCEEWGP DGKWTDPDGV
1260 1270 1280 1290 1300
MSLSRKQQQK FAAWKRLSEI VKDPVVIQDV PNSRAIRQGF VGDCSFLSSL
1310 1320 1330 1340 1350
AVLSEFERKH NVPVLSGLLY PQGTIPAVSE AGRRPQDGGE RVGPIFNPRG
1360 1370 1380 1390 1400
MYACRLYFNG VPRKVLIDDY VPVRKDNKLL AAHSSNKSEL WVTLLEKAFV
1410 1420 1430 1440 1450
KLMGGSYSMQ GSNPGADLYH LTGWIPETIP FRSDVHTGSP ASHKPIVTGR
1460 1470 1480 1490 1500
ENEDDEVVKD PKWTQIWTQL YLGLTAGRCV ACLGTSEVSD AAPSGLDFPE
1510 1520 1530 1540 1550
GVSVSSGIVA RHAYSILNYA EIEGHRLLYV KNPWGCVRWK GKFSPSDKAS
1560 1570 1580 1590 1600
WTQNMKEKLG YDPATAAKSD CGCFWIEWLD VVRWFSHLYV CWDNSCFPYQ
1610 1620 1630 1640 1650
AEIHSKWERS PFIENSSLAD DSHMVAFNPQ FHLRISPRPE DFASSALAGP
1660 1670 1680 1690 1700
YPFLSFPSLT SPASAASLPM PSNSPPGTPH TASLSPVPSF SQENQPVELW
1710 1720 1730 1740 1750
ILLSRHVRER QKDLATKYLA IHLHAASERA TCPPPPAKQG VYSNGECTLV
1760 1770 1780 1790 1800
KLRVHPHVFR DLFARDASDE GSRFPSDNSA KREEKGKKEA AGGRPPLPGF
1810 1820 1830 1840 1850
EGHQLLDASE FVLVVSQYSQ KDEFNFTIKV YGHVHSCLTQ LPPLLPTDAQ
1860 1870 1880 1890 1900
SIYFKNSWGP STAGGCSNDL WRYFTNPHIR LKVPQPCDAI FFLESPQEHS
1910 1920 1930 1940 1950
VNLRLFKNRV ATARLLRTGK ALSTGPYRAG CCMLKARLEA TTYTIIPSTF
1960 1970 1980 1990 2000
RPDDFDTFQL SLHVPGNVAK PRPVLLPQPY AIPPPSSLFY RVVDGRKCTR
2010 2020 2030 2040 2050
QVWARVALQV QGPTLVALRL QMPGPPEPGD VFPSLTVYRY TETAEREREV
2060 2070 2080 2090 2100
ESERSAERKN QKKLQFVIRS DLDGGLSEDG HTASSAAQDL FQKQVRTRKR

R
Length:2,101
Mass (Da):225,555
Last modified:June 13, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i562CEF6762C8639E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM055942 Genomic DNA Translation: CAJ20398.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM055942 Genomic DNA Translation: CAJ20398.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC02.029

Organism-specific databases

VEuPathDBiToxoDB:TGARI_293820
ToxoDB:TGCAST_293820
ToxoDB:TGCOUG_293820
ToxoDB:TGDOM2_293820
ToxoDB:TGFOU_293820
ToxoDB:TGGT1_293820
ToxoDB:TGMAS_293820
ToxoDB:TGME49_293820
ToxoDB:TGP89_293820
ToxoDB:TGPRC2_293820
ToxoDB:TGRH88_019110
ToxoDB:TGRUB_293820
ToxoDB:TGVAND_293820
ToxoDB:TGVEG_293820

Phylogenomic databases

OMAiPVELWIL

Family and domain databases

CDDicd00044, CysPc, 1 hit
InterProiView protein in InterPro
IPR022684, Calpain_cysteine_protease
IPR036213, Calpain_III_sf
IPR038765, Papain-like_cys_pep_sf
IPR001300, Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF00648, Peptidase_C2, 1 hit
PRINTSiPR00704, CALPAIN
SMARTiView protein in SMART
SM00230, CysPc, 1 hit
SUPFAMiSSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ1JT76_TOXGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1JT76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 2, 2021
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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