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Entry version 95 (16 Oct 2019)
Sequence version 3 (03 May 2011)
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Protein

Pectinesterase/pectinesterase inhibitor 18

Gene

PME18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts in the modification of cell walls via demethylesterification of cell wall pectin. Inhibits the elongation phase of protein synthesis.1 Publication

Miscellaneous

The PMEI region may act as an autoinhibitory domain and prevent untimely PME activity during transport.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. EC:3.2.2.22

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pectin degradation

This protein is involved in step 1 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Probable pectinesterase/pectinesterase inhibitor 7 (PME7), Probable pectinesterase 48 (PME48), Pectinesterase (AXX17_At1g11890), Probable pectinesterase 49 (PME49), Probable pectinesterase 50 (PME50), Pectinesterase (AXX17_At4g02940), Pectinesterase (AXX17_At3g17940), Pectinesterase (AXX17_At5g52320), Pectinesterase, Probable pectinesterase/pectinesterase inhibitor 19 (PME19), Probable pectinesterase/pectinesterase inhibitor 42 (PME42), Probable pectinesterase 15 (PME15), Probable pectinesterase/pectinesterase inhibitor 40 (PME40), Putative pectinesterase 14 (PME14), Pectinesterase (AXX17_At1g11920), Pectinesterase (At3g10720), Pectinesterase (AXX17_At3g30550), Probable pectinesterase 55 (PME55), Pectinesterase (PMEPCRF), PME26 (AXX17_At3g14890), Pectinesterase (AXX17_At4g18720), Probable pectinesterase/pectinesterase inhibitor 23 (PME23), Pectinesterase 4 (PME4), Putative pectinesterase/pectinesterase inhibitor 22 (PME22), Probable pectinesterase/pectinesterase inhibitor 39 (PME39), Pectinesterase (AXX17_At2g44790), Pectinesterase (AXX17_At1g48290), Pectinesterase (At3g14310), Pectinesterase (AXX17_At5g47900), Pectinesterase (AXX17_At4g38050), Pectinesterase (AXX17_At5g19650), Pectinesterase/pectinesterase inhibitor 18 (PME18), Putative pectinesterase/pectinesterase inhibitor 43 (PME43), Pectinesterase (AXX17_At3g31890), Pectinesterase (AXX17_At4g02900), Pectinesterase (AXX17_At3g43380), Probable pectinesterase/pectinesterase inhibitor 34 (PME34), PMEI domain-containing protein (AXX17_At5g64270), Pectinesterase 1 (PME1), Putative pectinesterase 63 (PME63), Putative pectinesterase 10 (PME10), Probable pectinesterase/pectinesterase inhibitor 64 (PME64), PMEI domain-containing protein (AXX17_At3g05180), Pectinesterase (F14I3.7), Pectinesterase 2 (PME2), Plant invertase/pectin methylesterase inhibitor superfamily (At3g49220), Pectinesterase (At3g49220), Probable pectinesterase 29 (PME29), Pectinesterase (AXX17_At4g38040), Probable pectinesterase/pectinesterase inhibitor 21 (PME21), Pectinesterase (AXX17_At2g22280), Putative pectinesterase/pectinesterase inhibitor 45 (PME45), Pectinesterase (At5g20860), Pectinesterase (AXX17_At4g02930), Probable pectinesterase/pectinesterase inhibitor 12 (PME12), Probable pectinesterase/pectinesterase inhibitor 44 (PME44), Probable pectinesterase 8 (PME8), PMEI domain-containing protein (AXX17_At5g27870), Pectinesterase (AXX17_At5g26780), Pectinesterase/pectinesterase inhibitor 3 (PME3), Pectinesterase (AXX17_At2g45340), Pectinesterase 31 (PME31), Pectinesterase (AXX17_At3g41380), Probable pectinesterase/pectinesterase inhibitor 25 (PME25), Pectinesterase (AXX17_At5g50300), Pectinesterase (AXX17_At1g24390), Pectinesterase (AXX17_At1g11900), Pectinesterase (AXX17_At3g36460), Probable pectinesterase/pectinesterase inhibitor 51 (PME51), Probable pectinesterase/pectinesterase inhibitor 58 (PME58), Pectinesterase (AXX17_At5g04430), Putative pectinesterase 57 (PME57), Probable pectinesterase/pectinesterase inhibitor 20 (PME20), Pectinesterase (PME44), Pectinesterase (AXX17_At3g10560), Pectinesterase (AXX17_At3g55110), Pectinesterase (AXX17_At3g10570), Probable pectinesterase/pectinesterase inhibitor 60 (PME60), Pectinesterase (AXX17_At3g53530), Probable pectinesterase/pectinesterase inhibitor 59 (PME59), Pectinesterase QRT1 (QRT1), Putative pectinesterase 11 (PME11), Pectinesterase PPME1 (PPME1), Pectinesterase (AXX17_At3g56460), Pectinesterase (AXX17_At3g06710), Probable pectinesterase/pectinesterase inhibitor 32 (PME32), Probable pectinesterase/pectinesterase inhibitor 33 (PME33), Probable pectinesterase/pectinesterase inhibitor 36 (PME36), Pectinesterase (AXX17_At1g01970), Probable pectinesterase/pectinesterase inhibitor 13 (PME13), Pectinesterase (AXX17_At4g06570), Pectinesterase (AXX17_At5g50310), Putative pectinesterase 52 (PME52), Probable pectinesterase/pectinesterase inhibitor 54 (PME54), Pectinesterase (AXX17_At2g33420), Pectinesterase, Pectinesterase (AXX17_At2g33420), Pectinesterase (At4g15980), Pectinesterase (AXX17_At2g40510), Pectinesterase (At1g53840), Probable pectinesterase/pectinesterase inhibitor 16 (PME16), Pectinesterase 5 (PME5), Probable pectinesterase 30 (PME30), Pectinesterase (PMEPCRA), Pectinesterase (AXX17_At1g48300), Pectinesterase (AXX17_At3g05190), Probable pectinesterase/pectinesterase inhibitor VGDH2 (VGDH2), Pectinesterase (AXX17_At3g26070), Putative pectinesterase/pectinesterase inhibitor 24 (PME24), Putative pectinesterase/pectinesterase inhibitor 26 (PME26), Pectinesterase, Probable pectinesterase/pectinesterase inhibitor 35 (PME35), Probable pectinesterase 68 (PME68), Pectinesterase (AXX17_At3g14900), Probable pectinesterase 67 (PME67), Pectinesterase (AXX17_At5g04420), Putative pectinesterase/pectinesterase inhibitor 38 (PME38), Probable pectinesterase 56 (PME56), Pectinesterase, Putative pectinesterase/pectinesterase inhibitor 28 (PME28), Probable pectinesterase/pectinesterase inhibitor 47 (PME47), Probable pectinesterase 53 (PME53), Probable pectinesterase/pectinesterase inhibitor 46 (PME46), Pectinesterase (AXX17_At2g44780), Pectinesterase (AXX17_At4g00230), Plant invertase/pectin methylesterase inhibitor superfamily (At5g09760), Probable pectinesterase/pectinesterase inhibitor 17 (PME17), Pectinesterase (AXX17_At5g20800), PMEI domain-containing protein (AXX17_At5g09310), Pectinesterase (AXX17_At2g22270), Pectinesterase (AXX17_At1g04730), Probable pectinesterase/pectinesterase inhibitor 41 (PME41), Probable pectinesterase/pectinesterase inhibitor 61 (PME61), Probable pectinesterase 66 (PME66), Pectinesterase (At5g26810), Pectinesterase (AXX17_At2g42790), Pectinesterase (AXX17_At5g45990), Probable pectinesterase/pectinesterase inhibitor 6 (PME6)
  2. Pectate lyase (AXX17_At4g28670), Pectate lyase (T26I12.20), Pectate lyase (AXX17_At5g62760), Putative pectate lyase 2 (At1g11920), Pectate lyase (AXX17_At3g47590), Pectate lyase (At3g07010), Pectate lyase, Pectate lyase (AXX17_At3g26720), Probable pectate lyase 8 (At3g07010), Probable pectate lyase 4 (At1g30350), Probable pectate lyase 7 (At3g01270), Pectate lyase (AXX17_At4g14900), Pectate lyase (AXX17_At1g30780), Probable pectate lyase 19 (At5g15110), Probable pectate lyase 18 (At4g24780), Pectate lyase (F11F8_12), Pectate lyase (At3g27400), Pectate lyase (AXX17_At3g49450), Probable pectate lyase 13 (PMR6), Probable pectate lyase 16 (At4g22080), Putative pectate lyase 17 (At4g22090), Pectate lyase (AXX17_At2g01680), Pectate lyase (AXX17_At4g25600), Pectate lyase (AXX17_At3g26200), Pectate lyase (AXX17_At3g09180), Probable pectate lyase 3 (AT59), Putative pectate lyase 14 (At4g13210), Probable pectate lyase 5 (At1g67750), Putative pectate lyase 21 (At5g55720), Pectate lyase (At4g13210), Probable pectate lyase 12 (At3g53190), Pectate lyase, Pectate lyase (At3g55140), Pectate lyase (AXX17_At1g61710), Pectate lyase (At5g04310), Probable pectate lyase 20 (At5g48900), Pectate lyase (AXX17_At5g47570), Pectate lyase (AXX17_At3g06910), Probable pectate lyase 6 (At2g02720), Pectate lyase (AXX17_At5g03700), Pectate lyase (AXX17_At5g54880), Pectate lyase (At4g13710), Pectate lyase (At1g14420), Pectate lyase (AXX17_At3g49720), Pectate lyase (AXX17_At4g15660), Pectate lyase (AXX17_At4g25610), Probable pectate lyase 15 (At4g13710), Pectate lyase (At3g53190), Pectate lyase, Pectate lyase (AXX17_At1g15010), Pectate lyase (At3g01270), Pectate lyase (At5g04310), Putative pectate lyase 11 (At3g27400), Pectate lyase, Pectate lyase, Pectate lyase (At3g09540), Pectate lyase (At3g07010), Pectate lyase (At5g09280), Probable pectate lyase 22 (At5g63180), Pectate lyase (AXX17_At1g12300), Pectate lyase (AXX17_At3g00310), Probable pectate lyase 9 (At3g24230), Pectate lyase (AXX17_At1g04020), Pectate lyase (AXX17_At3g29900), Pectate lyase (At3g01270), Probable pectate lyase 1 (At1g04680), Pectate lyase (At3g07010), Pectate lyase (AXX17_At5g14600), Pectate lyase (AXX17_At5g08800), Pectate lyase (At3g55140), Probable pectate lyase 10 (At3g24670)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei321Substrate; for pectinesterase activityBy similarity1
Binding sitei351Substrate; for pectinesterase activityBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei373Transition state stabilizerBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei374Proton donor; for pectinesterase activityPROSITE-ProRule annotation1
Active sitei395Nucleophile; for pectinesterase activityPROSITE-ProRule annotation1
Binding sitei463Substrate; for pectinesterase activityBy similarity1
Binding sitei465Substrate; for pectinesterase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntimicrobial, Aspartyl esterase, Fungicide, Hydrolase, Protein synthesis inhibitor, Toxin
Biological processCell wall biogenesis/degradation, Plant defense

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00545;UER00823

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pectinesterase/pectinesterase inhibitor 18
Alternative name(s):
AtPMEpcrA
Cleaved into the following 2 chains:
Alternative name(s):
Pectin methylesterase inhibitor 18
Bifunctional pectinesterase 18/rRNA N-glycosylase (EC:3.1.1.11, EC:3.2.2.22)
Short name:
PE 18
Alternative name(s):
Pectin methylesterase 18
Pectin methylesterase 4
Short name:
AtPME4
Ribosome-inactivating protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PME18
Synonyms:ARATH4
Ordered Locus Names:At1g11580
ORF Names:T23J18.23, T23J18.24, T23J18.33
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G11580

The Arabidopsis Information Resource

More...
TAIRi
locus:2200076 AT1G11580

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000037018235 – 557Pectinesterase/pectinesterase inhibitor 18Add BLAST523
ChainiPRO_000037018335 – 242Pectinesterase inhibitor 18Sequence analysisAdd BLAST208
ChainiPRO_0000370184243 – 557Bifunctional pectinesterase 18/rRNA N-glycosylaseAdd BLAST315

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1JPL7

PRoteomics IDEntifications database

More...
PRIDEi
Q1JPL7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q1JPL7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q1JPL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in siliques, flowers, floral stems, rosette leaves and roots.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during early seed development and late developmental phases of siliques.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1JPL7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q1JPL7 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
22941, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G11580.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1JPL7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 203Pectinesterase inhibitor 18Add BLAST157
Regioni246 – 543Pectinesterase 18Add BLAST298

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi292 – 295Poly-Lys4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the PMEI family.Curated
In the C-terminal section; belongs to the pectinesterase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II3N Eukaryota
COG4677 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217409

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1JPL7

KEGG Orthology (KO)

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KOi
K01051

Identification of Orthologs from Complete Genome Data

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OMAi
NRCQIDG

Database of Orthologous Groups

More...
OrthoDBi
674407at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.140.40, 1 hit
2.160.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
IPR018040 Pectinesterase_Tyr_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00856 PMEI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01614 PME_inhib, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00800 PECTINESTERASE_1, 1 hit
PS00503 PECTINESTERASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q1JPL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNSNQPLLS KPKSLKHKNL CLVLSFVAIL GSVAFFTAQL ISVNTNNNDD
60 70 80 90 100
SLLTTSQICH GAHDQDSCQA LLSEFTTLSL SKLNRLDLLH VFLKNSVWRL
110 120 130 140 150
ESTMTMVSEA RIRSNGVRDK AGFADCEEMM DVSKDRMMSS MEELRGGNYN
160 170 180 190 200
LESYSNVHTW LSSVLTNYMT CLESISDVSV NSKQIVKPQL EDLVSRARVA
210 220 230 240 250
LAIFVSVLPA RDDLKMIISN RFPSWLTALD RKLLESSPKT LKVTANVVVA
260 270 280 290 300
KDGTGKFKTV NEAVAAAPEN SNTRYVIYVK KGVYKETIDI GKKKKNLMLV
310 320 330 340 350
GDGKDATIIT GSLNVIDGST TFRSATVAAN GDGFMAQDIW FQNTAGPAKH
360 370 380 390 400
QAVALRVSAD QTVINRCRID AYQDTLYTHT LRQFYRDSYI TGTVDFIFGN
410 420 430 440 450
SAVVFQNCDI VARNPGAGQK NMLTAQGRED QNQNTAISIQ KCKITASSDL
460 470 480 490 500
APVKGSVKTF LGRPWKLYSR TVIMQSFIDN HIDPAGWFPW DGEFALSTLY
510 520 530 540 550
YGEYANTGPG ADTSKRVNWK GFKVIKDSKE AEQFTVAKLI QGGLWLKPTG

VTFQEWL
Length:557
Mass (Da):61,687
Last modified:May 3, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1A3C1620DCC127B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8ARX5A0A1P8ARX5_ARATH
Pectinesterase
PMEPCRA ATPMEPCRA, methylesterase PCR A, At1g11580, T23J18.24, T23J18_24
578Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF16636 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF16637 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14S → Y in AAK59760 (PubMed:14593172).Curated1
Sequence conflicti460F → Y in AAC02973 (PubMed:9767082).Curated1
Sequence conflicti467L → E in AAC02973 (PubMed:9767082).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011661 Genomic DNA Translation: AAF16636.1 Sequence problems.
AC011661 Genomic DNA Translation: AAF16637.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28755.1
AY037175 mRNA Translation: AAK59760.1
AY048217 mRNA Translation: AAK82480.1
BT025336 mRNA Translation: ABF57292.1
AF033205 Genomic DNA Translation: AAC02973.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A86249

NCBI Reference Sequences

More...
RefSeqi
NP_172624.1, NM_101031.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G11580.1; AT1G11580.1; AT1G11580

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
837701

Gramene; a comparative resource for plants

More...
Gramenei
AT1G11580.1; AT1G11580.1; AT1G11580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G11580

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011661 Genomic DNA Translation: AAF16636.1 Sequence problems.
AC011661 Genomic DNA Translation: AAF16637.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28755.1
AY037175 mRNA Translation: AAK59760.1
AY048217 mRNA Translation: AAK82480.1
BT025336 mRNA Translation: ABF57292.1
AF033205 Genomic DNA Translation: AAC02973.1
PIRiA86249
RefSeqiNP_172624.1, NM_101031.3

3D structure databases

SMRiQ1JPL7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi22941, 1 interactor
STRINGi3702.AT1G11580.1

PTM databases

iPTMnetiQ1JPL7
SwissPalmiQ1JPL7

Proteomic databases

PaxDbiQ1JPL7
PRIDEiQ1JPL7

Genome annotation databases

EnsemblPlantsiAT1G11580.1; AT1G11580.1; AT1G11580
GeneIDi837701
GrameneiAT1G11580.1; AT1G11580.1; AT1G11580
KEGGiath:AT1G11580

Organism-specific databases

AraportiAT1G11580
TAIRilocus:2200076 AT1G11580

Phylogenomic databases

eggNOGiENOG410II3N Eukaryota
COG4677 LUCA
HOGENOMiHOG000217409
InParanoidiQ1JPL7
KOiK01051
OMAiNRCQIDG
OrthoDBi674407at2759

Enzyme and pathway databases

UniPathwayiUPA00545;UER00823

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q1JPL7

Gene expression databases

ExpressionAtlasiQ1JPL7 baseline and differential
GenevisibleiQ1JPL7 AT

Family and domain databases

Gene3Di1.20.140.40, 1 hit
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
IPR018040 Pectinesterase_Tyr_AS
PfamiView protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit
SMARTiView protein in SMART
SM00856 PMEI, 1 hit
SUPFAMiSSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01614 PME_inhib, 1 hit
PROSITEiView protein in PROSITE
PS00800 PECTINESTERASE_1, 1 hit
PS00503 PECTINESTERASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPME18_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1JPL7
Secondary accession number(s): O49007
, Q94AF4, Q94C39, Q9LPX8, Q9LPX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 3, 2011
Last modified: October 16, 2019
This is version 95 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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