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Protein

Aldehyde dehydrogenase family 3 member B1

Gene

ALDH3B1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP+ and NAD+ as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.By similarity

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1), Aldehyde dehydrogenase, mitochondrial (ALDH2)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210PROSITE-ProRule annotation1
Active sitei244PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-BTA-1660661 Sphingolipid de novo biosynthesis
R-BTA-6798695 Neutrophil degranulation
UniPathwayi
UPA00780;UER00768

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B1 (EC:1.2.1.5)
Gene namesi
Name:ALDH3B1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Organism-specific databases

VGNCiVGNC:56255 ALDH3B1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599601 – 465Aldehyde dehydrogenase family 3 member B1Add BLAST465
PropeptideiPRO_0000424192466 – 468Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Lipidationi463S-palmitoyl cysteineBy similarity1
Modified residuei465Cysteine methyl esterCurated1
Lipidationi465S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ1JPA0
PeptideAtlasiQ1JPA0
PRIDEiQ1JPA0

Expressioni

Gene expression databases

BgeeiENSBTAG00000013093 Expressed in 9 organ(s), highest expression level in lung

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042081

Structurei

3D structure databases

ProteinModelPortaliQ1JPA0
SMRiQ1JPA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00390000002825
HOGENOMiHOG000271515
HOVERGENiHBG050483
InParanoidiQ1JPA0
KOiK00129
OMAiAPTIFMD
OrthoDBiEOG091G05HC
TreeFamiTF314264

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1JPA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPFADTLQR LREAFVSGRT RPAEFRDAQL KGLSRFLREN KQLLQEALAQ
60 70 80 90 100
DLHKSAFEAE VSEISISQNE INLALRNLRT WMKDEKVSKN LATQLDSAFI
110 120 130 140 150
RKEPFGLVLI LSPWNYPLNL SLGPLVGALA AGNCVVLKPS EISKNTEKVL
160 170 180 190 200
AEVLPRYLDQ SCFAVVLGGP QETGRLLEHK FDYIFFTGNP QVGKIVMTAA
210 220 230 240 250
AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAFFRCFNA GQTCVAPDYV
260 270 280 290 300
LCSPEMQAQL VPALQSAITR FYGDDPQSSP NLGRIISQKH FQRLRGLLSC
310 320 330 340 350
GRVVIGGQSD ECDLYIAPTV LVDVQETDPV MQEEIFGPIL PIVNVRSLGQ
360 370 380 390 400
AIDFINRREK PLALYAFSNS SQVVKRVLAQ TSSGGFCGND GFMHLTLASL
410 420 430 440 450
PFGGVGSSGM GNYHGKFSFD TFSHHRACLL RRPGLEKIYA IRYPPHTPRN
460
LRVLLMAMET RSCSCTLL
Length:468
Mass (Da):51,800
Last modified:June 13, 2006 - v1
Checksum:i7D14AF7895810ED8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27D → A in AAI47959 (Ref. 2) Curated1
Sequence conflicti66I → T in AAI47959 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025453 mRNA Translation: ABF57409.1
BT026328 mRNA Translation: ABG81484.1
BC147958 mRNA Translation: AAI47959.1
RefSeqiNP_001068986.1, NM_001075518.1
XP_005227117.2, XM_005227060.3
XP_005227118.1, XM_005227061.3
XP_005227119.1, XM_005227062.3
UniGeneiBt.111358

Genome annotation databases

EnsembliENSBTAT00000017408; ENSBTAP00000017408; ENSBTAG00000013093
ENSBTAT00000044598; ENSBTAP00000042081; ENSBTAG00000013093
GeneIDi511469
KEGGibta:511469

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025453 mRNA Translation: ABF57409.1
BT026328 mRNA Translation: ABG81484.1
BC147958 mRNA Translation: AAI47959.1
RefSeqiNP_001068986.1, NM_001075518.1
XP_005227117.2, XM_005227060.3
XP_005227118.1, XM_005227061.3
XP_005227119.1, XM_005227062.3
UniGeneiBt.111358

3D structure databases

ProteinModelPortaliQ1JPA0
SMRiQ1JPA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042081

Proteomic databases

PaxDbiQ1JPA0
PeptideAtlasiQ1JPA0
PRIDEiQ1JPA0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017408; ENSBTAP00000017408; ENSBTAG00000013093
ENSBTAT00000044598; ENSBTAP00000042081; ENSBTAG00000013093
GeneIDi511469
KEGGibta:511469

Organism-specific databases

CTDi221
VGNCiVGNC:56255 ALDH3B1

Phylogenomic databases

eggNOGiKOG2456 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00390000002825
HOGENOMiHOG000271515
HOVERGENiHBG050483
InParanoidiQ1JPA0
KOiK00129
OMAiAPTIFMD
OrthoDBiEOG091G05HC
TreeFamiTF314264

Enzyme and pathway databases

UniPathwayi
UPA00780;UER00768

ReactomeiR-BTA-1660661 Sphingolipid de novo biosynthesis
R-BTA-6798695 Neutrophil degranulation

Gene expression databases

BgeeiENSBTAG00000013093 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAL3B1_BOVIN
AccessioniPrimary (citable) accession number: Q1JPA0
Secondary accession number(s): A6QLG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: June 13, 2006
Last modified: October 10, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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