UniProtKB - Q1JP63 (SVOP_BOVIN)
Protein
Synaptic vesicle 2-related protein
Gene
SVOP
Organism
Bos taurus (Bovine)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptic vesicle 2-related proteinShort name: SV2-related protein |
Gene namesi | Name:SVOP |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:35498, SVOP |
Subcellular locationi
Other locations
- synaptic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- integral component of membrane Source: UniProtKB-KW
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 87 | CytoplasmicSequence analysisAdd BLAST | 87 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 109 – 122 | VesicularSequence analysisAdd BLAST | 14 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 156 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 180 | VesicularSequence analysis | 3 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 202 – 209 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 210 – 230 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 231 – 238 | VesicularSequence analysis | 8 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 316 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 317 – 337 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 338 – 373 | VesicularSequence analysisAdd BLAST | 36 | |
Transmembranei | 374 – 394 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 395 – 401 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 423 – 425 | VesicularSequence analysis | 3 | |
Transmembranei | 426 – 446 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 447 – 457 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 458 – 478 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 479 – 489 | VesicularSequence analysisAdd BLAST | 11 | |
Transmembranei | 490 – 510 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 511 – 548 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279451 | 1 – 548 | Synaptic vesicle 2-related proteinAdd BLAST | 548 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineBy similarity | 1 | |
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 542 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q1JP63 |
Expressioni
Tissue specificityi
Detected in brain and adrenal medulla.1 Publication
Gene expression databases
Bgeei | ENSBTAG00000018833, Expressed in brain and 10 other tissues |
ExpressionAtlasi | Q1JP63, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0253, Eukaryota KOG0255, Eukaryota |
GeneTreei | ENSGT00940000155403 |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q1JP63 |
OMAi | GAFIWLP |
OrthoDBi | 1430447at2759 |
TreeFami | TF313465 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004749, Orgcat_transp/SVOP |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00898, 2A0119, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q1JP63-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VRAGLEAVEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF VGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL LILSAVPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK
410 420 430 440 450
KTMALCFVVF SFCSLLLFIC VGRNMLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AALASCFLPI ETKGRGLQES SHREWGQEMV GRGAHGTGVA RSNSGSQE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A452DIU7 | A0A452DIU7_BOVIN | Synaptic vesicle 2-related protein | SVOP | 543 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023442 | 451 – 468 | VYPTA…CSGMA → LRSAQLSRALTLSHHPKS in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_023443 | 469 – 548 | Missing in isoform 2. 1 PublicationAdd BLAST | 80 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT025491 mRNA Translation: ABF57447.1 BC118274 mRNA Translation: AAI18275.1 |
RefSeqi | NP_001068909.1, NM_001075441.1 [Q1JP63-1] |
Genome annotation databases
Ensembli | ENSBTAT00000029565; ENSBTAP00000029564; ENSBTAG00000018833 [Q1JP63-1] |
GeneIDi | 510256 |
KEGGi | bta:510256 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT025491 mRNA Translation: ABF57447.1 BC118274 mRNA Translation: AAI18275.1 |
RefSeqi | NP_001068909.1, NM_001075441.1 [Q1JP63-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000029564 |
Proteomic databases
PaxDbi | Q1JP63 |
Genome annotation databases
Ensembli | ENSBTAT00000029565; ENSBTAP00000029564; ENSBTAG00000018833 [Q1JP63-1] |
GeneIDi | 510256 |
KEGGi | bta:510256 |
Organism-specific databases
CTDi | 55530 |
VGNCi | VGNC:35498, SVOP |
Phylogenomic databases
eggNOGi | KOG0253, Eukaryota KOG0255, Eukaryota |
GeneTreei | ENSGT00940000155403 |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q1JP63 |
OMAi | GAFIWLP |
OrthoDBi | 1430447at2759 |
TreeFami | TF313465 |
Gene expression databases
Bgeei | ENSBTAG00000018833, Expressed in brain and 10 other tissues |
ExpressionAtlasi | Q1JP63, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004749, Orgcat_transp/SVOP |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00898, 2A0119, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SVOP_BOVIN | |
Accessioni | Q1JP63Primary (citable) accession number: Q1JP63 Secondary accession number(s): Q17QM3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | June 13, 2006 | |
Last modified: | October 7, 2020 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families