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Entry version 54 (02 Jun 2021)
Sequence version 1 (13 Jun 2006)
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Protein

Large tegument protein deneddylase

Gene

BPLF1

Organism
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei48Important for catalytic activityUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei61UniRule annotation1
Active sitei193UniRule annotation1
Active sitei195UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processHost-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Large tegument protein deneddylaseUniRule annotation (EC:3.4.19.12UniRule annotation, EC:3.4.22.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BPLF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEpstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri82830 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007639 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003759691 – 3154Large tegument protein deneddylaseAdd BLAST3154

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q1HVH9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.

Interacts with inner tegument protein.

Interacts with capsid vertex specific component CVC2.

Interacts with the major capsid protein/MCP.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1HVH9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 258Peptidase C76UniRule annotationAdd BLAST218
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati335 – 33915
Repeati340 – 34425
Repeati345 – 34935
Repeati350 – 35445
Repeati355 – 35955
Repeati360 – 36465
Repeati365 – 36975
Repeati370 – 37485
Repeati375 – 37995

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 268Deubiquitination activityUniRule annotationAdd BLAST268
Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni319 – 341DisorderedSequence analysisAdd BLAST23
Regioni335 – 3799 X 5 AA repeats of P-A-S-A-AAdd BLAST45
Regioni387 – 661DisorderedSequence analysisAdd BLAST275
Regioni559 – 589Interaction with inner tegument proteinUniRule annotationAdd BLAST31
Regioni906 – 928DisorderedSequence analysisAdd BLAST23
Regioni1148 – 1171DisorderedSequence analysisAdd BLAST24
Regioni1413 – 1439DisorderedSequence analysisAdd BLAST27
Regioni1649 – 1682DisorderedSequence analysisAdd BLAST34
Regioni2588 – 2844DisorderedSequence analysisAdd BLAST257
Regioni2859 – 2986DisorderedSequence analysisAdd BLAST128
Regioni3000 – 3024DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Polar residuesSequence analysisAdd BLAST16
Compositional biasi319 – 337Polar residuesSequence analysisAdd BLAST19
Compositional biasi387 – 404Pro residuesSequence analysisAdd BLAST18
Compositional biasi419 – 433Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi456 – 494Pro residuesSequence analysisAdd BLAST39
Compositional biasi501 – 526Pro residuesSequence analysisAdd BLAST26
Compositional biasi527 – 542Polar residuesSequence analysisAdd BLAST16
Compositional biasi543 – 614Pro residuesSequence analysisAdd BLAST72
Compositional biasi1656 – 1670Pro residuesSequence analysisAdd BLAST15
Compositional biasi2594 – 2635Polar residuesSequence analysisAdd BLAST42
Compositional biasi2710 – 2726Pro residuesSequence analysisAdd BLAST17
Compositional biasi2727 – 2762Polar residuesSequence analysisAdd BLAST36
Compositional biasi2782 – 2813Polar residuesSequence analysisAdd BLAST32
Compositional biasi2820 – 2834Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2960 – 2974Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae large tegument protein family.UniRule annotation

Keywords - Domaini

Repeat

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_04044, HSV_LTP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006928, Herpes_teg_USP
IPR034702, HSV_LTP
IPR038765, Papain-like_cys_pep_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04843, Herpes_teg_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51521, HTUSP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1HVH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNGDWGQSQ RTRGTGPVRG IRTMDVNAPG GGSGGSALRI LGTASCNQAH
60 70 80 90 100
CKFGRFAGIQ CVSNCVLYLV KSFLAGRPLT SRPELDEVLD EGARLDALMR
110 120 130 140 150
QSGILKGHEM AQLTDVPSSV VLRGGGRVHI YRSAEIFGLV LFPAQIANSA
160 170 180 190 200
VVQSLAEVLH GSYNGVAQFI LYICDIYAGA IIIETDGSFY LFDPHCQKDA
210 220 230 240 250
APGTPAHVRV STYAHDILQY VGAPGAQYTC VHLYFLPEAF ETEDPRIFML
260 270 280 290 300
EHYGVYDFYE ANGSGFDLVG PELVSSDGEA AGTPGADSSP PVMLPFERRI
310 320 330 340 350
IPYNLRPLPS RSFTSDSFPA ARYSPAKTNS PPSSPASAAP ASAAPASAAP
360 370 380 390 400
ASAAPASAAP ASAAPASAAP ASAAPASAAP ASSPPLFIPI PGLGHTPGVP
410 420 430 440 450
APSTPPRASG GAAPQTPKRK KGLGKDSPHK KPTSGRRLPL SSTTDTEDDQ
460 470 480 490 500
LPRTHVPPHR PPSAARLPPP VIPIPHQSPP ASPTPRPAPV STIAPSVTPS
510 520 530 540 550
PRLPLQIPIP LPQAAPSNPE IPLTTPSPSP TAAAAPTATT LSPPPTQQQP
560 570 580 590 600
PQSAAPAPSP PPTQQQPPQS AAPAPSPLLP QQQPPPSAAR APSPLPPQQQ
610 620 630 640 650
PLPSATPAPP HAQQLPPSAT TLEPEKNNPS AADRAGTEIS PSPPFGQQPS
660 670 680 690 700
FGDDASGGSG LVRYLSDLEE PFLSMSDSEE AESDLASDIP TTEDEDMFED
710 720 730 740 750
EVFSNSLESG SSAPTSPITL DTARSQYYQT TFDIETPEMD FVPLESNIAR
760 770 780 790 800
IAGHTYQEQA IVYDPASNRE VPEADALSMI DYLLVTVVLE QGLIRSRDRS
810 820 830 840 850
AVLNLLEFLK DWSGHLQVPT LDLEQLLTSE LNIQNLANML SENKGRAGEF
860 870 880 890 900
HEHLAAKLEA CLPSLATKDA VRVDAGAKML AEIPQLAESG DGKFDLEAAR
910 920 930 940 950
RRLTDLLSGG DQEGEEGGGE PEDHSIYRGP HVDVPLVLDD ESWKRLLSLA
960 970 980 990 1000
EAARTAVARQ QAGVDEEDVR FLALLTAIEY GAPPAASVPP FVHNVPVRSK
1010 1020 1030 1040 1050
NAALHVRRCT ADIRDKVASA ASDYLSYLED PSLPTVMDFD DLLTHLRHTC
1060 1070 1080 1090 1100
QIIASLPLLN IRYTSIEWDY RELLYLGTAL SDMSGIPWPL ERVEEDDPSI
1110 1120 1130 1140 1150
APLPEFETVA KKQKELETTR ENEKRLRTIL DDIEAMLGLA GVASAPGAPI
1160 1170 1180 1190 1200
SPASPSATPA NHDNPEATPP LADTAALTIP VIEKYIANAG SIVGAAKNPT
1210 1220 1230 1240 1250
YIRLRDTIQQ IVRSKKYLMN ILKSITFYTI DNYIASFEES IDHLYRDLPV
1260 1270 1280 1290 1300
LDPEVQDGID RILDPMVSEA LHTFEMGNRL TLEPARLVAL QNFATHSTLK
1310 1320 1330 1340 1350
ETAAAVNLLP GLLAVYDATV TGQAPEDALR LLSGLQNQLS QTLIPGKLKK
1360 1370 1380 1390 1400
RFLSYLQKLK NNNNDQLRQK EVQAWRLEAE GFKPATEEQL EAFLDTAPNK
1410 1420 1430 1440 1450
ELKRQYEKKL RQLMETGRKE KEKLREQEDK ERRERRAREA NEAWARIRKA
1460 1470 1480 1490 1500
LGARPEPAPT SPDDWNTLLA SLLPDNTDSA AAAAAAVARN TDILDSLTQI
1510 1520 1530 1540 1550
LAAMLLGITR VRRERLRSLL VDDGGAAERM EAVEPGWFTE IETGPLARLD
1560 1570 1580 1590 1600
AWPATPAATA KEGGGGRGAE EAAGALFRAR TAADAIRSAL AQTRQALQSP
1610 1620 1630 1640 1650
DMKSAVVNTD LEAPYAEYER GLAGLLEKRR SAEAALTAIV SEYVDRTLPE
1660 1670 1680 1690 1700
ATNDPGQANL PPPPTIPQAT APPRLASDSA LWPKKPQLLT RRERDDLLQA
1710 1720 1730 1740 1750
TGDFFSELLT EAEAAEVRAL EEQVRESQTL MAKAHEMAAS TRRGFHTALE
1760 1770 1780 1790 1800
AVLSRSRDEA PDDELRSLLP SPPKAPVQAP LEAALARAAA GNGSWPYRKS
1810 1820 1830 1840 1850
LAAAKWIRGI CEAVRGLSEG ALALAGGVGA WLNLAAAADG EIHELTRLLE
1860 1870 1880 1890 1900
VEGMAQNSMD GMEELRLALA TLDPKRVAGG KETVADWKRR LSRLEAIIQE
1910 1920 1930 1940 1950
AQEESQLQGT LQDLVTQARG HTDPRQLKIV VEAARGLALG ASAGSQYALL
1960 1970 1980 1990 2000
KDKLLRYASA KQSFLAFYET AQPTVFVKHP LTNNLPLLIT ISAPPTGWGN
2010 2020 2030 2040 2050
GAPTRRAQFL AAAGPAKYAG TLWLETESPC DPLNPAYVSA DTQEPLNYIP
2060 2070 2080 2090 2100
VYHNFLEYVM PTVLENPEAF SLTPAGRPQA IGPPQDDQER RRRTLASVAS
2110 2120 2130 2140 2150
ARLSAAAADS YWDTWPDVES NAGELLREYV SAPKALMEDL ADNPIVAMTL
2160 2170 2180 2190 2200
LAHASLIASR NHPPYPAPAT DREVILLEQR EMMALLVGTH PAYAAAFLGA
2210 2220 2230 2240 2250
PSFYAGLGLV SALARDGGLG DLLSDSVLTY RLVRSPASGR GGMPSTTRGS
2260 2270 2280 2290 2300
NDGEDARRLT RHRIAGPPTG FIFFQDAWEE MDTRAALWPH PEFLGLVHNQ
2310 2320 2330 2340 2350
STARARACML LLARRCFAPE ALQQLWHSLR PLEGPVAFQD YLRDFVKQAY
2360 2370 2380 2390 2400
TRGEELPRAE GLEVPRETPS SYGTVTGRAL RNLMPYGTPI TGPKRGSGDT
2410 2420 2430 2440 2450
IPVSVFEAAV AAAFLGRPLT LFVSSQYLFN LKTLGQVRVV APLLYCDGHS
2460 2470 2480 2490 2500
EPFRSLVETI SLNFLQDLDG YSESFEPEMS IFARQAVWLR ELLTEARAAK
2510 2520 2530 2540 2550
PKEARPPTVA ILANRKNIIW KCFTYRHNLP DVQFYFNAAG ASRWPTDVLN
2560 2570 2580 2590 2600
PSFYEHEDPP LPVGYQLPPN PRNVQELFSG FPPRVGHGLV SGDGFQSADN
2610 2620 2630 2640 2650
TPASSDRLQQ LGGGETDQGE EGSTTAESEA SGPPSPQSPL LEKVAPGRPR
2660 2670 2680 2690 2700
DWLSPTSSPR DVTVTPGLAA PITLPGPRLM ARPYFGAETR ASESPDRSPG
2710 2720 2730 2740 2750
TSPRPWPKDS LELLPQPAPQ QPPSSPWASE QGPIVYTLSP NSTPSTASGS
2760 2770 2780 2790 2800
QKKHTIQIPG LVPSQKPSYP PSAPYKPGQS TGGIAPTPSA ASLTTFGLQP
2810 2820 2830 2840 2850
QDTQASSQDP PYGHSIMQRE KKQQGGREEA AEIRPSATRL PTAVGLRPRA
2860 2870 2880 2890 2900
PVVAAGAAAS ATPAFDPGEA PSGFPIPQAP ALGSGLAAPA HTPVGALAPR
2910 2920 2930 2940 2950
PQKTQAQRPQ DAAALPTPTI KAVGARPVPK ATGALAAGAR PRGQPTAAPP
2960 2970 2980 2990 3000
SAASPPRVSL PVRSRQQQSP AIPLPPMHSG SEPGARPEVR LSQYRHAGPQ
3010 3020 3030 3040 3050
TYTVRKEAPP SAASQLPKMP KCKDSMYYPP SGSARYPAPF QALSFSQSVA
3060 3070 3080 3090 3100
SPAPSSDQTT LLWNTPSVVT QFLSIEDIIR EVVTGGSTSG DLVVPSGSPS
3110 3120 3130 3140 3150
SLSTAAPEQD LRYSLTLSQA SRVLSRFVSQ LRRKLERSTH RLIADLERLK

FLYL
Length:3,154
Mass (Da):338,449
Last modified:June 13, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFD719F4742849CB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ279927 Genomic DNA Translation: ABB89229.1

NCBI Reference Sequences

More...
RefSeqi
YP_001129449.1, NC_009334.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5176165

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:5176165

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ279927 Genomic DNA Translation: ABB89229.1
RefSeqiYP_001129449.1, NC_009334.1

3D structure databases

SMRiQ1HVH9
ModBaseiSearch...

Proteomic databases

PRIDEiQ1HVH9

Genome annotation databases

GeneIDi5176165
KEGGivg:5176165

Family and domain databases

HAMAPiMF_04044, HSV_LTP, 1 hit
InterProiView protein in InterPro
IPR006928, Herpes_teg_USP
IPR034702, HSV_LTP
IPR038765, Papain-like_cys_pep_sf
PfamiView protein in Pfam
PF04843, Herpes_teg_N, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51521, HTUSP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTP_EBVA8
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1HVH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: June 13, 2006
Last modified: June 2, 2021
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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