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Protein

Epstein-Barr nuclear antigen 1

Gene

EBNA1

Organism
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host proteasome antigen processing by virus, Transcription, Transcription regulation, Viral immunoevasion, Viral latency, Viral latency initiation and maintenance

Names & Taxonomyi

Protein namesi
Recommended name:
Epstein-Barr nuclear antigen 1
Short name:
EBNA-1
Short name:
EBV nuclear antigen 1
Gene namesi
Name:EBNA1
ORF Names:BKRF1
OrganismiEpstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri82830 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007639 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003759331 – 641Epstein-Barr nuclear antigen 1Add BLAST641

Proteomic databases

PRIDEiQ1HVF7

Interactioni

Subunit structurei

Interacts with human USP7. Interacts with human EBP2; this interaction is important for the stable segregation of EBV episomes during cell division but not for the replication of the episomes. Interacts with BGLF4; this interaction facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function (By similarity).By similarity

Structurei

Secondary structure

1641
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiQ1HVF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni436 – 450Interaction with USP7By similarityAdd BLAST15

Sequence similaritiesi

Belongs to the herpesviridae EBNA1 family.Curated

Phylogenomic databases

KOiK19461
OrthoDBiVOG090000Z3

Family and domain databases

Gene3Di3.30.70.390, 1 hit
InterProiView protein in InterPro
IPR035975 E2/EBNA1_C_sf
IPR004186 EBNA1_DNA-bd
IPR037007 EBNA1_DNA-bd_sf
PfamiView protein in Pfam
PF02905 EBV-NA1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD037044 EBNA1_DNA_bd, 1 hit
SUPFAMiSSF54957 SSF54957, 1 hit

Sequencei

Sequence statusi: Complete.

Q1HVF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDEGPGTGP GNGLGQKEDT SGPDGSSGSG PQRRGGDNHG RGRGRGRGRG
60 70 80 90 100
GGRPGAPGGS GSGPRHRDGV RRPQKRPSCI GCKGAHGGTG AGGGAGAGGA
110 120 130 140 150
GAGGAGAGGA GAGGAGAGGA GAGGAGAGGA GAGGAGAGGA GAGGGAGAGG
160 170 180 190 200
AGAGGAGAGG GAGAGGGAGA GGGAGAGGGA GAGGGAGAGG GAGAGGGAGA
210 220 230 240 250
GGGAGAGGGA GAGGAGAGGA GAGGGAGAGG GAGAGGGAGA GGGAGAGGGA
260 270 280 290 300
GAGGGAGAGG GAGAGGGAGA GGGAGAGGGA GAGGGAGAGG GAGAGGGAGA
310 320 330 340 350
GGGAGAGGGA GAGGGAGAGG GAGAGGGGRG RGGSGGRGRG GSGGRGRGGS
360 370 380 390 400
GGRRGRGRER ARGGSRERAR GRGRGRGEKR PRSPSSQSSS SGSPPRRPPP
410 420 430 440 450
GRRPFFHPVA EADYFEYHQE GGPDGEPDMP PGAIEQGPAD DPGEGPSTGP
460 470 480 490 500
RGQGDGGRRK KGGWYGKHRG EGGSSQKFEN IAEGLRLLLA RCHVERTTED
510 520 530 540 550
GNWVAGVFVY GGSKTSLYNL RRGIGLAIPQ CRLTPLSRLP FGMAPGPGPQ
560 570 580 590 600
PGPLRESIVC YFIVFLQTHI FAEGLKDAIK DLVLPKPAPT CNIKVTVCSF
610 620 630 640
DDGVDLPPWF PPMVEGAAAE GDDGDDGDEG GDGDEGEEGQ E
Length:641
Mass (Da):56,496
Last modified:June 13, 2006 - v1
Checksum:i53A0B8451AC7A621
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ279927 Genomic DNA Translation: ABB89251.1
RefSeqiYP_001129471.1, NC_009334.1

Genome annotation databases

GeneIDi5176225
KEGGivg:5176225

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ279927 Genomic DNA Translation: ABB89251.1
RefSeqiYP_001129471.1, NC_009334.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PRBX-ray1.75C407-417[»]
4PRNX-ray1.65C407-417[»]
SMRiQ1HVF7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ1HVF7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5176225
KEGGivg:5176225

Phylogenomic databases

KOiK19461
OrthoDBiVOG090000Z3

Family and domain databases

Gene3Di3.30.70.390, 1 hit
InterProiView protein in InterPro
IPR035975 E2/EBNA1_C_sf
IPR004186 EBNA1_DNA-bd
IPR037007 EBNA1_DNA-bd_sf
PfamiView protein in Pfam
PF02905 EBV-NA1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD037044 EBNA1_DNA_bd, 1 hit
SUPFAMiSSF54957 SSF54957, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEBNA1_EBVA8
AccessioniPrimary (citable) accession number: Q1HVF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: June 13, 2006
Last modified: September 12, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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