UniProtKB - Q1HAQ0 (PCAT1_RAT)
Protein
Lysophosphatidylcholine acyltransferase 1
Gene
Lpcat1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Exhibits acyltransferase activity (PubMed:16864775). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:16864775). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16864775). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (By similarity).By similarity1 Publication
Catalytic activityi
- a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA1 PublicationEC:2.3.1.231 Publication
- 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoABy similarityEC:2.3.1.67By similarity
- a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA1 PublicationEC:2.3.1.511 Publication
- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoABy similarityEC:2.3.1.25By similarity
- 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1ʼ-sn-glycerol) + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Activity is stimulated by Mg2+ or Mn2+.1 Publication
: phospholipid metabolism Pathwayi
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 392 – 403 | 1PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: UniProtKB
- 1-acylglycerophosphocholine O-acyltransferase activity Source: UniProtKB
- 1-alkenylglycerophosphocholine O-acyltransferase activity Source: UniProtKB
- 1-alkylglycerophosphocholine O-acetyltransferase activity Source: UniProtKB
- 1-alkylglycerophosphocholine O-acyltransferase activity Source: RGD
- calcium ion binding Source: InterPro
- plasmalogen synthase activity Source: UniProtKB-EC
GO - Biological processi
- negative regulation of phosphatidylcholine biosynthetic process Source: RGD
- phosphatidylcholine acyl-chain remodeling Source: RGD
- phospholipid biosynthetic process Source: UniProtKB
- positive regulation of protein catabolic process Source: RGD
- retina development in camera-type eye Source: RGD
- surfactant homeostasis Source: RGD
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 2.3.1.23, 5301 |
Reactomei | R-RNO-1482788, Acyl chain remodelling of PC R-RNO-1482925, Acyl chain remodelling of PG R-RNO-1483166, Synthesis of PA R-RNO-1483191, Synthesis of PC R-RNO-6798695, Neutrophil degranulation |
UniPathwayi | UPA00085 |
Chemistry databases
SwissLipidsi | SLP:000000296 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.231 Publication)Short name: LPC acyltransferase 1 Short name: LPCAT-1 Short name: LysoPC acyltransferase 1 Alternative name(s): 1-acylglycerol-3-phosphate O-acyltransferase (EC:2.3.1.511 Publication) 1-acylglycerophosphocholine O-acyltransferase 1-alkenylglycerophosphocholine O-acyltransferase (EC:2.3.1.25By similarity) 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67By similarity) Acetyl-CoA:lyso-platelet-activating factor acetyltransferase Short name: Acetyl-CoA:lyso-PAF acetyltransferase Short name: Lyso-PAF acetyltransferase Short name: LysoPAFAT Acyltransferase-like 2 |
Gene namesi | Name:Lpcat1 Synonyms:Aytl2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311599, Lpcat1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
Plasma membrane
- Cell membrane By similarity; Single-pass type II membrane protein By similarity
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type II membrane protein By similarity
Other locations
- Lipid droplet By similarity
Note: May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- lipid droplet Source: UniProtKB-SubCell
- membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 57 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 58 – 78 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 534 | LumenalSequence analysisAdd BLAST | 456 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, Lipid droplet, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247066 | 1 – 534 | Lysophosphatidylcholine acyltransferase 1Add BLAST | 534 |
Proteomic databases
jPOSTi | Q1HAQ0 |
PaxDbi | Q1HAQ0 |
PRIDEi | Q1HAQ0 |
PTM databases
SwissPalmi | Q1HAQ0 |
Expressioni
Tissue specificityi
Enriched in alveolar type II cells of lung. Also highly expressed in stomach.2 Publications
Inductioni
By FGF7.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000017930, Expressed in lung and 21 other tissues |
Genevisiblei | Q1HAQ0, RN |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 379 – 414 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 451 – 486 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 135 – 140 | HXXXXD motifBy similarity | 6 | |
Motifi | 531 – 534 | Di-lysine motifBy similarity | 4 |
Domaini
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.By similarity
The di-lysine motif may confer endoplasmic reticulum localization.By similarity
Sequence similaritiesi
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated
Keywords - Domaini
Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4666, Eukaryota |
GeneTreei | ENSGT01000000214580 |
HOGENOMi | CLU_025017_0_1_1 |
InParanoidi | Q1HAQ0 |
OMAi | EIEFLPI |
OrthoDBi | 1266853at2759 |
PhylomeDBi | Q1HAQ0 |
TreeFami | TF323244 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00563, PlsC, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q1HAQ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLRGRGPRA APSSSSGAGD ARRLAPPGRN PFVHELRLSA LQKAQVAFMT
60 70 80 90 100
LTLFPIRLLF AAFMMLLAWP FALVASLGPP DKEPEQPLAL WRKVVDFLLK
110 120 130 140 150
AIMRTMWFAG GFHRVAVKGR QALPTEAAIL TLAPHSSYFD AIPVTMTMSS
160 170 180 190 200
IVMKAESRDI PIWGTLIRYI RPVFVSRSDQ DSRRKTVEEI KRRAQSNGKW
210 220 230 240 250
PQIMIFPEGT CTNRTCLITF KPGAFIPGVP VQPVVLRYPN KLDTITWTWQ
260 270 280 290 300
GPGALKILWL TLCQFQNQVE IEFLPVYCPS EEEKRNPALY ASNVRRVMAK
310 320 330 340 350
ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPENLEK
360 370 380 390 400
DLDKYSESAR MKRGEKIRLP EFAAYLEVPV SDALEDMFSL FDESGGGEID
410 420 430 440 450
LREYVVALSV VCRPSQTLAT IQLAFKMYGS PEDGSIDEAD LSCILKTALG
460 470 480 490 500
ISELTVTDLF QAIDQEERGR ITFDDFCGFA EMYPDFAEDY LYPDQTHSDS
510 520 530
CAQTPPAPTP NGFCIDFSPE HSDFGRKNSC KKVD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03001349 Genomic DNA No translation available. AABR03001854 Genomic DNA No translation available. AB244983 mRNA Translation: BAE94689.2 |
RefSeqi | NP_001094205.1, NM_001100735.1 |
Genome annotation databases
Ensembli | ENSRNOT00000024111; ENSRNOP00000024111; ENSRNOG00000017930 |
GeneIDi | 361467 |
KEGGi | rno:361467 |
UCSCi | RGD:1311599, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03001349 Genomic DNA No translation available. AABR03001854 Genomic DNA No translation available. AB244983 mRNA Translation: BAE94689.2 |
RefSeqi | NP_001094205.1, NM_001100735.1 |
3D structure databases
SMRi | Q1HAQ0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024111 |
Chemistry databases
SwissLipidsi | SLP:000000296 |
PTM databases
SwissPalmi | Q1HAQ0 |
Proteomic databases
jPOSTi | Q1HAQ0 |
PaxDbi | Q1HAQ0 |
PRIDEi | Q1HAQ0 |
Genome annotation databases
Ensembli | ENSRNOT00000024111; ENSRNOP00000024111; ENSRNOG00000017930 |
GeneIDi | 361467 |
KEGGi | rno:361467 |
UCSCi | RGD:1311599, rat |
Organism-specific databases
CTDi | 79888 |
RGDi | 1311599, Lpcat1 |
Phylogenomic databases
eggNOGi | KOG4666, Eukaryota |
GeneTreei | ENSGT01000000214580 |
HOGENOMi | CLU_025017_0_1_1 |
InParanoidi | Q1HAQ0 |
OMAi | EIEFLPI |
OrthoDBi | 1266853at2759 |
PhylomeDBi | Q1HAQ0 |
TreeFami | TF323244 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
BRENDAi | 2.3.1.23, 5301 |
Reactomei | R-RNO-1482788, Acyl chain remodelling of PC R-RNO-1482925, Acyl chain remodelling of PG R-RNO-1483166, Synthesis of PA R-RNO-1483191, Synthesis of PC R-RNO-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:Q1HAQ0 |
Gene expression databases
Bgeei | ENSRNOG00000017930, Expressed in lung and 21 other tissues |
Genevisiblei | Q1HAQ0, RN |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00563, PlsC, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCAT1_RAT | |
Accessioni | Q1HAQ0Primary (citable) accession number: Q1HAQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | July 25, 2006 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families