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Protein

Telomere zinc finger-associated protein

Gene

Zbtb48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 306C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 394C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri400 – 423C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri429 – 452C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri458 – 480C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 537C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri543 – 565C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Telomere zinc finger-associated proteinBy similarity
Short name:
TZAPBy similarity
Alternative name(s):
Krueppel-related zinc finger protein 3 homologBy similarity
Zinc finger and BTB domain-containing protein 48Imported
Gene namesi
Name:Zbtb48Imported
Synonyms:Hkr3, TzapBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140248 Zbtb48

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002921361 – 681Telomere zinc finger-associated proteinAdd BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ1H9T6
PaxDbiQ1H9T6
PeptideAtlasiQ1H9T6
PRIDEiQ1H9T6

PTM databases

PhosphoSitePlusiQ1H9T6

Expressioni

Gene expression databases

BgeeiENSMUSG00000028952 Expressed in 168 organ(s), highest expression level in testis
CleanExiMM_ZBTB48
ExpressionAtlasiQ1H9T6 baseline and differential
GenevisibleiQ1H9T6 MM

Interactioni

Subunit structurei

Interacts with EP300.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221379, 31 interactors
IntActiQ1H9T6, 31 interactors
STRINGi10090.ENSMUSP00000067521

Structurei

Secondary structure

1681
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ1H9T6
SMRiQ1H9T6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ1H9T6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 89BTBPROSITE-ProRule annotationAdd BLAST64

Domaini

The C2H2-type zinc fingers mediate binding to the telomeric double-stranded 5'-TTAGGG-3' repeats. The last C2H2-type zinc finger is required for telomeric-binding.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 306C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 394C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri400 – 423C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri429 – 452C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri458 – 480C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 537C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri543 – 565C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150986
HOGENOMiHOG000049146
HOVERGENiHBG000087
InParanoidiQ1H9T6
KOiK10519
OMAiGNNEWEV
OrthoDBiEOG091G02KC
TreeFamiTF331310

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q1H9T6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF
60 70 80 90 100
FQRIYGDGTG GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAK
110 120 130 140 150
ELRVPEAVEL CQSFQPQTSV GQAQSGLGQP ASQDVKSHLK EPTDLDEEEV
160 170 180 190 200
FRTLSLASVD QEPRDTEQPQ LGTPAQSTTA FLCGKLTQAL KPSPSEDKES
210 220 230 240 250
EDCKEPPRPF EAGGAPLQGE SNEWEVVVQV EDDRDGDYVS EPETVLTRRK
260 270 280 290 300
SKVIRKPCAA EPALGAGSLT AEPTDSRKGA AVPVECPTCH KKFLSKYYLK
310 320 330 340 350
VHNRKHTGEK PFECPKCGKC YFRKENLLEH EARNCMNRSE QVFTCSVCQE
360 370 380 390 400
TFRRRMELRL HMVSHTGEMP YKCSSCSQQF MQKKDLQSHM IKLHGAPKPH
410 420 430 440 450
ACPTCAKCFL SRTELQLHEA FKHRGEKLFV CEECGHRASS RNGLQMHIKA
460 470 480 490 500
KHRNERPYVC EFCSHAFTQK ANLNMHLRTH TGEKPFQCHL CGKTFRTQAS
510 520 530 540 550
LDKHNRTHTG ERPFSCEFCE QRFTEKGPLL RHVASRHQEG RPHFCQICGK
560 570 580 590 600
TFKAVEQLRV HVRRHKGVRK FECTECGYKF TRQAHLRRHM EIHDRVENYN
610 620 630 640 650
PRQRKLRNLI IEDEKMVVVA LQPPADLEVG SAEVIVESLT QGGLASQLPS
660 670 680
QRLCSEESFA SPGVLEPSLI ITAAVPEDCD T
Length:681
Mass (Da):76,800
Last modified:June 27, 2006 - v1
Checksum:iCA2480B57098CCB3
GO
Isoform 2 (identifier: Q1H9T6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-681: CPTCAKCFLS...TAAVPEDCDT → VSASQGWGSG...HPHGREAFQL

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:547
Mass (Da):59,473
Checksum:i0339BC0A2503CD59
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZA56F6ZA56_MOUSE
Telomere zinc finger-associated pro...
Zbtb48
164Annotation score:
A0A0A0MQG8A0A0A0MQG8_MOUSE
Telomere zinc finger-associated pro...
Zbtb48
193Annotation score:

Sequence cautioni

The sequence CAM24576 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152R → K in AAH05515 (PubMed:15489334).Curated1
Sequence conflicti178T → S in AAH05515 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q1H9T6-2)
Sequence conflicti476D → G in AAH05515 (PubMed:15489334).Curated1
Sequence conflicti512H → R in AAH05515 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026381402 – 681CPTCA…EDCDT → VSASQGWGSGGSGTAQSCPH LDVLPLPVSPTCSAPLVPSA SCLGRSYSCTRLLSIVEKSS LCVRNAGTGPRAATDCRCTS RPSTGMKGLMSVSSAAMPSP RRPTSTCTCAHTPARSLSSA TSVGRPSAPKFGQAQPHPHG REAFQL in isoform 2. 1 PublicationAdd BLAST280

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM161454 mRNA Translation: CAJ44110.1
AL611927 Genomic DNA Translation: CAM24576.2 Sequence problems.
BC005515 mRNA Translation: AAH05515.1
CCDSiCCDS38982.1 [Q1H9T6-1]
RefSeqiNP_598640.2, NM_133879.2 [Q1H9T6-1]
UniGeneiMm.24661

Genome annotation databases

EnsembliENSMUST00000066715; ENSMUSP00000067521; ENSMUSG00000028952 [Q1H9T6-1]
ENSMUST00000155389; ENSMUSP00000114726; ENSMUSG00000028952 [Q1H9T6-2]
GeneIDi100090
KEGGimmu:100090
UCSCiuc008vyz.1 mouse [Q1H9T6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM161454 mRNA Translation: CAJ44110.1
AL611927 Genomic DNA Translation: CAM24576.2 Sequence problems.
BC005515 mRNA Translation: AAH05515.1
CCDSiCCDS38982.1 [Q1H9T6-1]
RefSeqiNP_598640.2, NM_133879.2 [Q1H9T6-1]
UniGeneiMm.24661

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLQNMR-A284-394[»]
2YY9X-ray2.60A/B8-129[»]
ProteinModelPortaliQ1H9T6
SMRiQ1H9T6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221379, 31 interactors
IntActiQ1H9T6, 31 interactors
STRINGi10090.ENSMUSP00000067521

PTM databases

PhosphoSitePlusiQ1H9T6

Proteomic databases

MaxQBiQ1H9T6
PaxDbiQ1H9T6
PeptideAtlasiQ1H9T6
PRIDEiQ1H9T6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066715; ENSMUSP00000067521; ENSMUSG00000028952 [Q1H9T6-1]
ENSMUST00000155389; ENSMUSP00000114726; ENSMUSG00000028952 [Q1H9T6-2]
GeneIDi100090
KEGGimmu:100090
UCSCiuc008vyz.1 mouse [Q1H9T6-1]

Organism-specific databases

CTDi3104
MGIiMGI:2140248 Zbtb48

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150986
HOGENOMiHOG000049146
HOVERGENiHBG000087
InParanoidiQ1H9T6
KOiK10519
OMAiGNNEWEV
OrthoDBiEOG091G02KC
TreeFamiTF331310

Miscellaneous databases

ChiTaRSiZbtb48 mouse
EvolutionaryTraceiQ1H9T6
PROiPR:Q1H9T6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028952 Expressed in 168 organ(s), highest expression level in testis
CleanExiMM_ZBTB48
ExpressionAtlasiQ1H9T6 baseline and differential
GenevisibleiQ1H9T6 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTZAP_MOUSE
AccessioniPrimary (citable) accession number: Q1H9T6
Secondary accession number(s): A2A8B1, Q99K15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 27, 2006
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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