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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168UniRule annotation1
Active sitei194UniRule annotation1
Active sitei290UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciMFLA265072:G1G69-2073-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:Mfla_1930
OrganismiMethylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875)
Taxonomic identifieri265072 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesMethylophilaceaeMethylobacillus
Proteomesi
  • UP000002440 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642901 – 355Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi265072.Mfla_1930

Structurei

3D structure databases

ProteinModelPortaliQ1GZZ0
SMRiQ1GZZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini156 – 348CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151423
KOiK03412
OMAiMLEMHRA
OrthoDBiPOG091H045J

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q1GZZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKVLIIDD SALIRSLLTE IINQQPDLEV VGTAPDPLIA REMIKQKNPD
60 70 80 90 100
VLTLDVEMPK MDGLDFLERL MRLRPMPVVM ISSLTERGSE ITMRAMELGA
110 120 130 140 150
VDFVTKPKIS IANGMHEYSE MIADKIRAAS RARLIARKPL TPVAGGAGLP
160 170 180 190 200
LVGNPLISSE KLIIIGASTG GTEAIKSFLM QMPSDCPGIL ITQHMPAGFT
210 220 230 240 250
QSFANRLNAL CKISVQEAKG GERVLPGHAY IAPGHSHLLL ARSGANYVTQ
260 270 280 290 300
LDDGPPVSRH RPSVDVLFSS AANNAGKNAI GVILTGMGKD GAEGMLKMKQ
310 320 330 340 350
AGAYNFAQDE ASCVVFGMPK EAIAMGGVDD VSSLNDMPGR VLQYLAANSG

RALRV
Length:355
Mass (Da):37,881
Last modified:June 27, 2006 - v1
Checksum:i85B5C0FD5CF30F34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000284 Genomic DNA Translation: ABE50197.1
RefSeqiWP_011480151.1, NC_007947.1

Genome annotation databases

EnsemblBacteriaiABE50197; ABE50197; Mfla_1930
KEGGimfa:Mfla_1930

Similar proteinsi

Entry informationi

Entry nameiCHEB_METFK
AccessioniPrimary (citable) accession number: Q1GZZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 27, 2006
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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