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UniProtKB - Q1GAA2 (Q1GAA2_LACDA)
Protein
Submitted name:
D-isomer specific 2-hydroxyacid dehydrogenase
Gene
Ldb1010
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 178 | NADCombined sources | 1 | |
Binding sitei | 208 | NAD; via carbonyl oxygenCombined sources | 1 | |
Binding sitei | 235 | NAD; via carbonyl oxygenCombined sources | 1 | |
Binding sitei | 261 | NADCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 156 – 159 | NADCombined sources | 4 |
GO - Molecular functioni
- NAD binding Source: InterPro
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | NADCombined sources, Nucleotide-bindingCombined sources |
Enzyme and pathway databases
BRENDAi | 1.1.1.345, 2853 |
Names & Taxonomyi
Protein namesi | Submitted name: D-isomer specific 2-hydroxyacid dehydrogenaseImported |
Gene namesi | Ordered Locus Names:Ldb1010Imported |
Organismi | Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14)Imported |
Taxonomic identifieri | 390333 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 332 | 2-Hacid_dhInterPro annotationAdd BLAST | 327 | |
Domaini | 113 – 300 | 2-Hacid_dh_CInterPro annotationAdd BLAST | 188 |
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotationARBA annotation
Phylogenomic databases
eggNOGi | COG1052, Bacteria |
HOGENOMi | CLU_019796_1_1_9 |
OMAi | TAYYTDH |
Family and domain databases
InterProi | View protein in InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR029753, D-isomer_DH_CS IPR006140, D-isomer_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389, 2-Hacid_dh, 1 hit PF02826, 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00670, D_2_HYDROXYACID_DH_2, 1 hit PS00671, D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q1GAA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKIAMYNVS PIEVPYIEDW AKKNDVEIKT TDQALTSATV DLAEGCSSVS
60 70 80 90 100
LKPLGPVDEE VVYQKLSEYG VKCIGLRIVG FNTINFDWTK KYNLLVTNVP
110 120 130 140 150
VYSPRAIAEM TVTQAMYLLR KIGEFRYRMD HDHDFTWPSN LISNEIYNLT
160 170 180 190 200
VGLIGVGHIG SAVAEIFSAM GAKVIAYDVA YNPEFEPFLT YTDFDTVLKE
210 220 230 240 250
ADIVSLHTPL FPSTENMIGE KQLKEMKKSA YLINCARGEL VDTGALIKAL
260 270 280 290 300
QDGEIAGAGL DTLAGESSYF GHTGLTDSEI PEDYKTLAKM PNVVITPHSA
310 320 330
FYTETSIRNM VQICLTDQLT IAKGGRPRSI VNL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR954253 Genomic DNA Translation: CAI97812.1 |
RefSeqi | WP_003619653.1, NZ_JQAV01000013.1 |
Genome annotation databases
EnsemblBacteriai | CAI97812; CAI97812; Ldb1010 |
GeneIDi | 66399923 |
KEGGi | ldb:Ldb1010 |
PATRICi | fig|390333.13.peg.679 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR954253 Genomic DNA Translation: CAI97812.1 |
RefSeqi | WP_003619653.1, NZ_JQAV01000013.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YQ4 | X-ray | 3.45 | A/B/C/D | 1-333 | [»] | |
2YQ5 | X-ray | 2.75 | A/B/C/D | 1-333 | [»] | |
SMRi | Q1GAA2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 390333.Ldb1010 |
Genome annotation databases
EnsemblBacteriai | CAI97812; CAI97812; Ldb1010 |
GeneIDi | 66399923 |
KEGGi | ldb:Ldb1010 |
PATRICi | fig|390333.13.peg.679 |
Phylogenomic databases
eggNOGi | COG1052, Bacteria |
HOGENOMi | CLU_019796_1_1_9 |
OMAi | TAYYTDH |
Enzyme and pathway databases
BRENDAi | 1.1.1.345, 2853 |
Family and domain databases
InterProi | View protein in InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR029753, D-isomer_DH_CS IPR006140, D-isomer_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389, 2-Hacid_dh, 1 hit PF02826, 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00670, D_2_HYDROXYACID_DH_2, 1 hit PS00671, D_2_HYDROXYACID_DH_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q1GAA2_LACDA | |
Accessioni | Q1GAA2Primary (citable) accession number: Q1GAA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | January 19, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |