gmk

Functionⁱ

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityⁱ

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	12 – 19	ATPUniRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
guanylate kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	LDEL390333:G1GJD-1240-MONOMER.

BioCycⁱ

LDEL390333:G1GJD-1240-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation) Alternative name(s): GMP kinaseUniRule annotation
Gene namesⁱ	Name:gmkUniRule annotation Ordered Locus Names:Ldb1415
Organismⁱ	Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
Taxonomic identifierⁱ	390333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus delbrueckii ›
Proteomesⁱ	UP000001259 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00328

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000266339	1 – 204	Guanylate kinaseAdd BLAST		204

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	390333.Ldb1415.

STRINGⁱ

390333.Ldb1415.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q1G9H8.
SMRⁱ	Q1G9H8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 184	Guanylate kinase-likeUniRule annotationAdd BLAST		180

Sequence similaritiesⁱ

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108UHA. Bacteria. COG0194. LUCA.
HOGENOMⁱ	HOG000037639.
KEGG Orthology (KO) More...KOⁱ	K00942.
OMAⁱ	AGNYYGT.

Family and domain databases

HAMAPⁱ	MF_00328. Guanylate_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR008145. GK/Ca_channel_bsu. IPR008144. Guanylate_kin-like_dom. IPR017665. Guanylate_kinase. IPR020590. Guanylate_kinase_CS. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00625. Guanylate_kin. 1 hit.
SMARTⁱ	View protein in SMART SM00072. GuKc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR03263. guanyl_kin. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q1G9H8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADKGLLLVL SGPSGVGKGT VKSAIVEHKV FPFEYSVSMT TRKPREGEVN 
        60         70         80         90        100
GKDYYFVTRE EFKQAIADNQ LLEYNEYVGN LYGTPLGPVK EMLAAGKDVL 
       110        120        130        140        150
LEIDVNGART VRQQMPEGVF IFLTPPDLHT LRDRLEHRGT ESEDVIRGRI 
       160        170        180        190        200
AQARKEILVM QDYDYAVVND TVANAVNHIK AIVDAEHVSV RRVIDDYRKM 

VKED

Length:204

Mass (Da):22,967

Last modified:June 27, 2006 - v1

Checksum:ⁱF19A3EA20916852F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR954253 Genomic DNA. Translation: CAI98216.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011544043.1. NZ_JQAV01000009.1.

Genome annotation databases

EnsemblBacteriaⁱ	CAI98216; CAI98216; Ldb1415.
GeneIDⁱ	4085315.
KEGGⁱ	ldb:Ldb1415.
PATRICⁱ	fig\|390333.13.peg.1953.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q1G9H8	A0A061C9C9 A0A2I1SRD9 E4SVB3 A0A0R2N058 A0A1X9TTM1 F0HTZ0 A0A061C0J5 F0K381 G6F4F3 D8FMP4 +8	Lactobacillus delbrueckii subsp. lactis Lactobacillus delbrueckii Lactobacillus delbrueckii subsp. bulgaricus (strain ND02) Lactobacillus delbrueckii subsp. jakobsenii ZN7a-9 = DSM 26046 Lactobacillus delbrueckii subsp. delbrueckii Lactobacillus delbrueckii subsp. lactis DSM 20072 Lactobacillus delbrueckii subsp. bulgaricus Lactobacillus delbrueckii subsp. bulgaricus (strain 2038) Lactobacillus delbrueckii subsp. bulgaricus CNCM I-1519 Lactobacillus delbrueckii subsp. bulgaricus PB2003/044-T3-4 And more	204	UniRef90_Q1G9H8	Cluster: Guanylate kinase	19

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q1G9H8	O34328 A0A063XHT2 A0A199WHL7 D4FWG4 G4EWH6 A0A1X7D8S0 A0A1Y0WPE6 L8AKY0 A0A0T8PPS4 M4KY70 +1794	Bacillus subtilis (strain 168) Bacillus subtilis Bacillus subtilis subsp. subtilis Bacillus subtilis subsp. natto (strain BEST195) Bacillus subtilis subsp. subtilis str. SC-8 Bacillus sp. CC120222-01 Bacillus licheniformis Bacillus subtilis BEST7613 Streptococcus pneumoniae Bacillus subtilis XF-1 And more	204	UniRef50_O34328	Cluster: Guanylate kinase	1,805

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR954253 Genomic DNA. Translation: CAI98216.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011544043.1. NZ_JQAV01000009.1.

3D structure databases

ProteinModelPortalⁱ	Q1G9H8.
SMRⁱ	Q1G9H8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	390333.Ldb1415.

STRINGⁱ

390333.Ldb1415.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAI98216; CAI98216; Ldb1415.
GeneIDⁱ	4085315.
KEGGⁱ	ldb:Ldb1415.
PATRICⁱ	fig\|390333.13.peg.1953.

Phylogenomic databases

eggNOGⁱ	ENOG4108UHA. Bacteria. COG0194. LUCA.
HOGENOMⁱ	HOG000037639.
KEGG Orthology (KO) More...KOⁱ	K00942.
OMAⁱ	AGNYYGT.

Enzyme and pathway databases

BioCycⁱ	LDEL390333:G1GJD-1240-MONOMER.

BioCycⁱ

LDEL390333:G1GJD-1240-MONOMER.

Family and domain databases

HAMAPⁱ	MF_00328. Guanylate_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR008145. GK/Ca_channel_bsu. IPR008144. Guanylate_kin-like_dom. IPR017665. Guanylate_kinase. IPR020590. Guanylate_kinase_CS. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00625. Guanylate_kin. 1 hit.
SMARTⁱ	View protein in SMART SM00072. GuKc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR03263. guanyl_kin. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KGUA_LACDA
Accessionⁱ	Q1G9H8Primary (citable) accession number: Q1G9H8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	June 27, 2006
	Last modified:	March 28, 2018
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q1G9H8 (KGUA_LACDA)

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Guanylate kinase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ