UniProtKB - Q1G9H8 (KGUA_LACDA)
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Protein
Guanylate kinase
Gene
gmk
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
Status
Functioni
Essential for recycling GMP and indirectly, cGMP.UniRule annotation
Catalytic activityi
ATP + GMP = ADP + GDP.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 19 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- guanylate kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | LDEL390333:G1GJD-1240-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)Alternative name(s): GMP kinaseUniRule annotation |
Gene namesi | Name:gmkUniRule annotation Ordered Locus Names:Ldb1415 |
Organismi | Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778) |
Taxonomic identifieri | 390333 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000266339 | 1 – 204 | Guanylate kinaseAdd BLAST | 204 |
Structurei
3D structure databases
ProteinModelPortali | Q1G9H8. |
SMRi | Q1G9H8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 184 | Guanylate kinase-likeUniRule annotationAdd BLAST | 180 |
Sequence similaritiesi
Belongs to the guanylate kinase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108UHA. Bacteria. COG0194. LUCA. |
HOGENOMi | HOG000037639. |
KOi | K00942. |
OMAi | AGNYYGT. |
Family and domain databases
HAMAPi | MF_00328. Guanylate_kinase. 1 hit. |
InterProi | View protein in InterPro IPR008145. GK/Ca_channel_bsu. IPR008144. Guanylate_kin-like_dom. IPR017665. Guanylate_kinase. IPR020590. Guanylate_kinase_CS. IPR027417. P-loop_NTPase. |
Pfami | View protein in Pfam PF00625. Guanylate_kin. 1 hit. |
SMARTi | View protein in SMART SM00072. GuKc. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
TIGRFAMsi | TIGR03263. guanyl_kin. 1 hit. |
PROSITEi | View protein in PROSITE PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q1G9H8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADKGLLLVL SGPSGVGKGT VKSAIVEHKV FPFEYSVSMT TRKPREGEVN
60 70 80 90 100
GKDYYFVTRE EFKQAIADNQ LLEYNEYVGN LYGTPLGPVK EMLAAGKDVL
110 120 130 140 150
LEIDVNGART VRQQMPEGVF IFLTPPDLHT LRDRLEHRGT ESEDVIRGRI
160 170 180 190 200
AQARKEILVM QDYDYAVVND TVANAVNHIK AIVDAEHVSV RRVIDDYRKM
VKED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR954253 Genomic DNA. Translation: CAI98216.1. |
RefSeqi | WP_011544043.1. NZ_JQAV01000009.1. |
Genome annotation databases
EnsemblBacteriai | CAI98216; CAI98216; Ldb1415. |
GeneIDi | 4085315. |
KEGGi | ldb:Ldb1415. |
PATRICi | fig|390333.13.peg.1953. |
Similar proteinsi
Entry informationi
Entry namei | KGUA_LACDA | |
Accessioni | Q1G9H8Primary (citable) accession number: Q1G9H8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | March 28, 2018 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |