gmk

Functionⁱ

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityⁱ

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	12 – 19	ATPUniRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
guanylate kinase activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	LDEL390333:LDB_RS06075-MONOMER

BioCycⁱ

LDEL390333:LDB_RS06075-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation) Alternative name(s): GMP kinaseUniRule annotation
Gene namesⁱ	Name:gmkUniRule annotation Ordered Locus Names:Ldb1415
Organismⁱ	Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
Taxonomic identifierⁱ	390333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus delbrueckii ›
Proteomesⁱ	UP000001259 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00328

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000266339	1 – 204	Guanylate kinaseAdd BLAST		204

Proteomic databases

PRIDEⁱ	Q1G9H8

PRIDEⁱ

Q1G9H8

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	390333.Ldb1415

STRINGⁱ

390333.Ldb1415

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q1G9H8
SMRⁱ	Q1G9H8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 184	Guanylate kinase-likeUniRule annotationAdd BLAST		180

Sequence similaritiesⁱ

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108UHA Bacteria COG0194 LUCA
HOGENOMⁱ	HOG000037639
KEGG Orthology (KO) More...KOⁱ	K00942
OMAⁱ	AGNYYGT

Family and domain databases

HAMAPⁱ	MF_00328 Guanylate_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR008145 GK/Ca_channel_bsu IPR008144 Guanylate_kin-like_dom IPR017665 Guanylate_kinase IPR020590 Guanylate_kinase_CS IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00625 Guanylate_kin, 1 hit
SMARTⁱ	View protein in SMART SM00072 GuKc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR03263 guanyl_kin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00856 GUANYLATE_KINASE_1, 1 hit PS50052 GUANYLATE_KINASE_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q1G9H8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADKGLLLVL SGPSGVGKGT VKSAIVEHKV FPFEYSVSMT TRKPREGEVN 
        60         70         80         90        100
GKDYYFVTRE EFKQAIADNQ LLEYNEYVGN LYGTPLGPVK EMLAAGKDVL 
       110        120        130        140        150
LEIDVNGART VRQQMPEGVF IFLTPPDLHT LRDRLEHRGT ESEDVIRGRI 
       160        170        180        190        200
AQARKEILVM QDYDYAVVND TVANAVNHIK AIVDAEHVSV RRVIDDYRKM 

VKED

Length:204

Mass (Da):22,967

Last modified:June 27, 2006 - v1

Checksum:ⁱF19A3EA20916852F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR954253 Genomic DNA Translation: CAI98216.1
NCBI Reference Sequences More...RefSeqⁱ	WP_011544043.1, NZ_JQAV01000009.1

Genome annotation databases

EnsemblBacteriaⁱ	CAI98216; CAI98216; Ldb1415
GeneIDⁱ	4085315
KEGGⁱ	ldb:Ldb1415
PATRICⁱ	fig\|390333.13.peg.1953

Protein	Similar proteins		Species	Score	Length	Source
Q1G9H8	Guanylate kinase		Lactobacillus delbrueckii subsp. lactis DSM 20072		204	UniRef90_Q1G9H8
Guanylate kinase		LACDE		204
Guanylate kinase		LACD2		204
Guanylate kinase		Lactobacillus delbrueckii subsp. bulgaricus CNCM I-1519		204
Guanylate kinase		LACDL		204
+12

Protein	Similar proteins		Species	Score	Length	Source
Q1G9H8	Guanylate kinase		LACPL		206	UniRef50_Q88WL7
Guanylate kinase		LACJO		204
Guanylate kinase		LACAC		204
Guanylate kinase		STRT1		209
Guanylate kinase		STRT2		209
+1055

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR954253 Genomic DNA Translation: CAI98216.1
RefSeqⁱ	WP_011544043.1, NZ_JQAV01000009.1

3D structure databases

ProteinModelPortalⁱ	Q1G9H8
SMRⁱ	Q1G9H8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	390333.Ldb1415

STRINGⁱ

390333.Ldb1415

Proteomic databases

PRIDEⁱ	Q1G9H8

PRIDEⁱ

Q1G9H8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAI98216; CAI98216; Ldb1415
GeneIDⁱ	4085315
KEGGⁱ	ldb:Ldb1415
PATRICⁱ	fig\|390333.13.peg.1953

Phylogenomic databases

eggNOGⁱ	ENOG4108UHA Bacteria COG0194 LUCA
HOGENOMⁱ	HOG000037639
KOⁱ	K00942
OMAⁱ	AGNYYGT

Enzyme and pathway databases

BioCycⁱ	LDEL390333:LDB_RS06075-MONOMER

BioCycⁱ

LDEL390333:LDB_RS06075-MONOMER

Family and domain databases

HAMAPⁱ	MF_00328 Guanylate_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR008145 GK/Ca_channel_bsu IPR008144 Guanylate_kin-like_dom IPR017665 Guanylate_kinase IPR020590 Guanylate_kinase_CS IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF00625 Guanylate_kin, 1 hit
SMARTⁱ	View protein in SMART SM00072 GuKc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR03263 guanyl_kin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00856 GUANYLATE_KINASE_1, 1 hit PS50052 GUANYLATE_KINASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KGUA_LACDA
Accessionⁱ	Q1G9H8Primary (citable) accession number: Q1G9H8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	June 27, 2006
	Last modified:	October 10, 2018
	This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - Q1G9H8 (KGUA_LACDA)

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Guanylate kinase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ