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Protein

Probable mitochondrial import inner membrane translocase subunit TIM21

Gene

TIM21

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mitochondrial import inner membrane translocase subunit TIM21
Alternative name(s):
Protein SEGREGATION DISTORTION 3
Gene namesi
Name:TIM21
Synonyms:SD3
Ordered Locus Names:At4g00026
ORF Names:F6N15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G00026
TAIRilocus:1009023383 AT4G00026

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei130 – 152HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Strong lethality at the post-seedling stage.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 70MitochondrionSequence analysisAdd BLAST70
ChainiPRO_000042093171 – 269Probable mitochondrial import inner membrane translocase subunit TIM21Add BLAST199

Proteomic databases

PaxDbiQ1G3L1

PTM databases

iPTMnetiQ1G3L1

Expressioni

Tissue specificityi

Expressed in leaves, sheath, flowers and buds. Lower expression in roots and stems.1 Publication

Gene expression databases

ExpressionAtlasiQ1G3L1 baseline and differential

Interactioni

Subunit structurei

Part of the respiratory complex III. Interacts with TIM23-2 and the cytochrome c1 and c2 subunits of complex III.1 Publication

Protein-protein interaction databases

BioGridi530772, 1 interactor
STRINGi3702.AT4G00026.1

Structurei

3D structure databases

ProteinModelPortaliQ1G3L1
SMRiQ1G3L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 4Poly-Met4

Sequence similaritiesi

Belongs to the TIM21 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHM2 Eukaryota
ENOG4111I5D LUCA
InParanoidiQ1G3L1
KOiK17796
OMAiPIKGYGQ
OrthoDBiEOG09360NI7
PhylomeDBiQ1G3L1

Family and domain databases

Gene3Di3.10.450.320, 1 hit
InterProiView protein in InterPro
IPR013261 Tim21
IPR038552 Tim21_IMS_sf
PANTHERiPTHR13032 PTHR13032, 1 hit
PfamiView protein in Pfam
PF08294 TIM21, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1G3L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMMNLLRRS AIAIGRQSKS KLASFSSATQ PCSGIPKSSK RVFSNSFLSK
60 70 80 90 100
DSTGANGLLF RFRNPQASIC TEARPKNINS SYFTRSFASR TSKEPGNQQN
110 120 130 140 150
KAKKEVTTVE DPFDSPTYHI PEKPVTFTEG ASYSLVILAG LGVAGAAGYG
160 170 180 190 200
VFKELIFQPK EYKVFDKALK RIQDDGQVRV RIGSPIKGYG QETRNRAARQ
210 220 230 240 250
RIPNRVFTDE DGVEHVEVNF YIRGPQGAGK VYTEMFKDKA EKEWKYTYLI
260
VEILTPSPAK LMLESYLPA
Length:269
Mass (Da):30,047
Last modified:May 3, 2011 - v1
Checksum:i5488EF57160AEBC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069299 Genomic DNA No translation available.
CP002687 Genomic DNA Translation: AEE81815.1
DQ487573 mRNA Translation: ABF59236.1
AK228629 mRNA Translation: BAF00539.1
RefSeqiNP_001031562.1, NM_001036485.4
UniGeneiAt.50764

Genome annotation databases

EnsemblPlantsiAT4G00026.1; AT4G00026.1; AT4G00026
GeneIDi3770411
GrameneiAT4G00026.1; AT4G00026.1; AT4G00026
KEGGiath:AT4G00026

Similar proteinsi

Entry informationi

Entry nameiTIM21_ARATH
AccessioniPrimary (citable) accession number: Q1G3L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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