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UniProtKB - Q1ENI8 (PXDN1_CAEEL)

Entry version 120 (25 May 2022)
Sequence version 1 (11 Jul 2006)
Previous versions | rss
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Protein

Peroxidasin homolog pxn-1

Gene

pxn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV NC1 hexamer (By similarity).

Plays a role in the attachment of tissues and in axonal guidance during early developmental stages (PubMed:25475546).

May functionally antagonize the peroxidasin pxn-2 to maintain neuronal development (PubMed:20876652, PubMed:26194821).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei719Heme b; covalent, via 2 linksPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei720Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi721CalciumPROSITE-ProRule annotation1
Metal bindingi803CalciumPROSITE-ProRule annotation1
Metal bindingi805Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi807CalciumPROSITE-ProRule annotation1
Metal bindingi809CalciumPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei874Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei877Heme b; covalent, via 2 linksPROSITE-ProRule annotation1
Metal bindingi973Iron (heme b axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-209968, Thyroxine biosynthesis
R-CEL-2243919, Crosslinking of collagen fibrils
R-CEL-6798695, Neutrophil degranulation
R-CEL-8941413, Events associated with phagocytolytic activity of PMN cells

Protein family/group databases

PeroxiBase, a peroxidase database

More...PeroxiBasei		3359, CelPxd01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxidasin homolog pxn-1Curated (EC:1.11.2.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pxn-1Imported
ORF Names:ZK994.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...WormBasei		ZK994.3 ; CE40298 ; WBGene00004256 ; pxn-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031962321 – 1285Peroxidasin homolog pxn-1Add BLAST1265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi49N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi248N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi336 ↔ 385PROSITE-ProRule annotation
Disulfide bondi429 ↔ 479PROSITE-ProRule annotation
Glycosylationi595N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi625 ↔ 641PROSITE-ProRule annotation
Disulfide bondi740 ↔ 750PROSITE-ProRule annotation
Glycosylationi741N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Disulfide bondi744 ↔ 771PROSITE-ProRule annotation
Glycosylationi858N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Disulfide bondi1076 ↔ 1133PROSITE-ProRule annotation
Disulfide bondi1174 ↔ 1201PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q1ENI8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q1ENI8

PeptideAtlas

More...PeptideAtlasi		Q1ENI8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q1ENI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the ventral nerve cord, the dorsal nerve cord, head neurons, GABAergic and cholinergic neurons, body wall muscles, vulval muscles, uterine muscles, intestine, the hypodermis and in coelomocytes.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from embryogenesis to adulthood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00004256, Expressed in material anatomical entity and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		56017, 3 interactors

STRING: functional protein association networks

More...STRINGi		6239.ZK994.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q1ENI8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q1ENI8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 53LRRNTAdd BLAST33
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati27 – 49LRR 1Sequence analysisAdd BLAST23
Repeati50 – 72LRR 2Sequence analysisAdd BLAST23
Repeati73 – 96LRR 3Sequence analysisAdd BLAST24
Repeati97 – 120LRR 4Sequence analysisAdd BLAST24
Repeati122 – 143LRR 5Sequence analysisAdd BLAST22
Repeati145 – 168LRR 6Sequence analysisAdd BLAST24
Domaini180 – 228LRRCTSequence analysisAdd BLAST49
Repeati204 – 227LRR 7Sequence analysisAdd BLAST24
Domaini315 – 401Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST87
Domaini408 – 495Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST88
Repeati998 – 1022LRR 10Sequence analysisAdd BLAST25
Repeati1049 – 1073LRR 11Sequence analysisAdd BLAST25
Repeati1168 – 1189LRR 12Sequence analysisAdd BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni305 – 324DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili508 – 550Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi308 – 323Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota
KOG2408, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000168557

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006087_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q1ENI8

Identification of Orthologs from Complete Genome Data

More...OMAi		FHRKYRA

Database of Orthologous Groups

More...OrthoDBi		276568at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q1ENI8

Family and domain databases

Conserved Domains Database

More...CDDi		cd09826, peroxidasin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.640.10, 1 hit
2.60.40.10, 2 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR034824, Peroxidasin_peroxidase
IPR034826, Peroxidasin_PXN-1_nema

The PANTHER Classification System

More...PANTHERi		PTHR11475:SF74, PTHR11475:SF74, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07679, I-set, 2 hits
PF13855, LRR_8, 2 hits
PF01462, LRRNT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits
SM00369, LRR_TYP, 3 hits
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48113, SSF48113, 1 hit
SSF48726, SSF48726, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 2 hits
PS50292, PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q1ENI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLYLLLLVI ATSSWQFVAG LECPVECTCD KKGLVVDCSS SGLTRIPKNI 
        60         70         80         90        100
SRNVRSLVIR NNRIHKLKRS DLEGFNQLET LVLTHNKIKI IEENVLDHLP 
       110        120        130        140        150
ELKRLSLAHN ELVYIPPLCS DSRPLASLNL KRNHIQFIDE QVLRYFPDLT 
       160        170        180        190        200
QLDFSHNRIQ SLRTKLFDNL PALSHAHLHS NPWHCDCRAS KVKALLQKVK 
       210        220        230        240        250
WEKKVYCTNP VELRHQALDE VDDSALTCAR PAEESWTGEE IKLTCAKNSS 
       260        270        280        290        300
SKLVVWMYEN VEVDSSSLDG YEIHDTVITV PRKTNVNFMT CTYDFDHIPH 
       310        320        330        340        350
HRRLRQSQHQ GNGSPQFTYK PRDNSFREGS EVKVNCEVMG NPKPTINWYH 
       360        370        380        390        400
NGKRFISSRK RQLGLSNNVL RIYPFLEEDS GRYTCEAVNS VGKVRHAFSL 
       410        420        430        440        450
DLISSVPPNI YEGPQSVSQN LGGSVVFVCK ANGNPVPDYT WSFDGSTIGH 
       460        470        480        490        500
IKGRFMVSDD GTELRISNIE KKDEGYYSCM AGNPVGAMSA DAKLTVIGGE 
       510        520        530        540        550
TRKAAAPQID EELLRAIAQK ARQNVENAVE KTRKQLTQDK VTNTNDLKRL 
       560        570        580        590        600
FRFSTPKQAV ELSKAREIYE ESVRLVREHV EKGLILNVDE LHPKNVSYES 
       610        620        630        640        650
VLHVTHVQAL MGLSGCHTGQ YKNPCTDTCF HHRYRSFDGQ CNNKNKPMTG 
       660        670        680        690        700
VSLMPLRRLL KPVYENGFNT PVGWEKGRLY NGYPLPNVRE VSRQLVATEN 
       710        720        730        740        750
ITPHSKLSSM VMQWGQFVDH DLTHTVTALS RHSYATGAFC NRTCENLDPC 
       760        770        780        790        800
FNIPLSPNDP RVKSGSAKYP CIEFERSAAV CGSGETSLVF NRVTYREQMN 
       810        820        830        840        850
ALTSFLDASN VYGSNEVQAQ ELRDTYNNNG MLRFDITSEA GKEYLPFEKD 
       860        870        880        890        900
SNMDCRRNFS EENPIRCFLA GDLRANEQLA LAATHTIFIR EHNRIAKKLK 
       910        920        930        940        950
SMNGNWDGEI IYHETRKIVG AMMQHITYKH WMPIIFGGQA QMNKFVGTYQ 
       960        970        980        990       1000
GYDPDVDASV TNAFATAAFR FGHTIINPSL FRLGNDFMPI KEGHIALHKA 
      1010       1020       1030       1040       1050
FFTPELVLTQ GGVDPLLRGL FASPLKHPMP TQLLNMELIE KLFMKGHEVS 
      1060       1070       1080       1090       1100
LDLAVMNIQR SRDHGLPSYT EYRKFCNLPV PVQWEDMKGY IKDDMIIQKL 
      1110       1120       1130       1140       1150
RGLYGVPQNI DLWVGGIVEE KLENGLFGPT FACIIGEQFR KIRDGDRFWY 
      1160       1170       1180       1190       1200
EKDGVFTPEQ LREIKKITLA RLFCDNGDNI DRIQKDVFMY PGMDKENYGT 
      1210       1220       1230       1240       1250
CQETEMMNLR AWSKCCDNVC PTMLDRILRS RHRGSRLHGC NQNGIWRPEG 
      1260       1270       1280 
AKWIPQNEIC TECVCQGSRV WCSTKEDCSD NRSPF
Length:1,285
Mass (Da):146,337
Last modified:July 11, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7110A400C54655D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD71290.1

NCBI Reference Sequences

More...RefSeqi		NP_505188.3, NM_072787.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		ZK994.3.1; ZK994.3.1; WBGene00004256

Database of genes from NCBI RefSeq genomes

More...GeneIDi		191484

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_ZK994.3

UCSC genome browser

More...UCSCi		ZK994.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD71290.1
RefSeqiNP_505188.3, NM_072787.3

3D structure databases

AlphaFoldDBiQ1ENI8
SMRiQ1ENI8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi56017, 3 interactors
STRINGi6239.ZK994.3

Protein family/group databases

PeroxiBasei3359, CelPxd01

PTM databases

iPTMnetiQ1ENI8

Proteomic databases

EPDiQ1ENI8
PaxDbiQ1ENI8
PeptideAtlasiQ1ENI8

Genome annotation databases

EnsemblMetazoaiZK994.3.1; ZK994.3.1; WBGene00004256
GeneIDi191484
KEGGicel:CELE_ZK994.3
UCSCiZK994.3, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		191484
WormBaseiZK994.3 ; CE40298 ; WBGene00004256 ; pxn-1

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
KOG2408, Eukaryota
GeneTreeiENSGT00940000168557
HOGENOMiCLU_006087_0_0_1
InParanoidiQ1ENI8
OMAiFHRKYRA
OrthoDBi276568at2759
PhylomeDBiQ1ENI8

Enzyme and pathway databases

ReactomeiR-CEL-209968, Thyroxine biosynthesis
R-CEL-2243919, Crosslinking of collagen fibrils
R-CEL-6798695, Neutrophil degranulation
R-CEL-8941413, Events associated with phagocytolytic activity of PMN cells

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q1ENI8

Gene expression databases

BgeeiWBGene00004256, Expressed in material anatomical entity and 4 other tissues

Family and domain databases

CDDicd09826, peroxidasin_like, 1 hit
Gene3Di1.10.640.10, 1 hit
2.60.40.10, 2 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR034824, Peroxidasin_peroxidase
IPR034826, Peroxidasin_PXN-1_nema
PANTHERiPTHR11475:SF74, PTHR11475:SF74, 1 hit
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07679, I-set, 2 hits
PF13855, LRR_8, 2 hits
PF01462, LRRNT, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits
SM00369, LRR_TYP, 3 hits
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit
SUPFAMiSSF48113, SSF48113, 1 hit
SSF48726, SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 2 hits
PS50292, PEROXIDASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXDN1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1ENI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 11, 2006
Last modified: May 25, 2022
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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