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Protein

Peptidase 1

Gene
N/A
Organism
Psoroptes ovis (Sheep scab mite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable thiol protease.

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134By similarity1
Active sitei270By similarity1
Active sitei290By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase 1 (EC:3.4.22.65)
Alternative name(s):
Mite group 1 allergen Pso o 1
Allergen: Pso o 1
OrganismiPsoroptes ovis (Sheep scab mite)
Taxonomic identifieri83912 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaSarcoptoideaPsoroptidaePsoroptes

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei739 Pso o 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000030776619 – 99By similarityAdd BLAST81
ChainiPRO_0000307767100 – 322Peptidase 1Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi131 ↔ 171By similarity
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ1EIQ3

Expressioni

Tissue specificityi

Expressed in the gut.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ1EIQ3
SMRiQ1EIQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1EIQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFVLAIASL LVLSVVYAYP SEIRTFEEFK KAFNKHYVTP EAEQEARQNF
60 70 80 90 100
LASLEHIEKA GKGRINQFSD MSLEEFKNQY LMSDQAYEAL KKEFDLDAGA
110 120 130 140 150
QACQIGAVNI PNEIDLRALG YVTKIKNQVA CGSCWAFSGV ATVESNYLSY
160 170 180 190 200
DNVSLDLSEQ ELVDCASQHG CGGDTVLNGL RYIQKNGVVE EQSYPYKARE
210 220 230 240 250
GRCQRPNAKR YGIKDLCQIY PPNGDKIRTY LATKQAALSV IIGIRDLDSF
260 270 280 290 300
RHYDGRTILQ SDNGGKRNFH AINIVGYGSK QGVRYWIIRN SWDTTWGDKG
310 320
YGYFVADKNL MGIEKFPLAA ML
Length:322
Mass (Da):36,250
Last modified:July 11, 2006 - v1
Checksum:i29FD93A5CE89D85B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM269885 mRNA Translation: CAK32515.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM269885 mRNA Translation: CAK32515.1

3D structure databases

ProteinModelPortaliQ1EIQ3
SMRiQ1EIQ3
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei739 Pso o 1

Proteomic databases

PRIDEiQ1EIQ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEPT1_PSOOV
AccessioniPrimary (citable) accession number: Q1EIQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 11, 2006
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Allergens
    Nomenclature of allergens and list of entries
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