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Entry version 108 (08 May 2019)
Sequence version 2 (20 May 2008)
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Protein

Sodium-coupled monocarboxylate transporter 2

Gene

SLC5A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an electroneutral and low-affinity sodium (Na+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na+ for each lactate (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Cotransport of monocarboxylates and nicotinate strongly inhibited by ibuprofen, fenoprofen and ketoprofen.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427601 Multifunctional anion exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.21.5.6 the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-coupled monocarboxylate transporter 2
Alternative name(s):
Electroneutral sodium monocarboxylate cotransporter
Low-affinity sodium-lactate cotransporter
Solute carrier family 5 member 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC5A12
Synonyms:SMCT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28750 SLC5A12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612455 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q1EHB4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9ExtracellularSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 47CytoplasmicSequence analysisAdd BLAST17
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 82ExtracellularSequence analysisAdd BLAST14
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 128CytoplasmicSequence analysisAdd BLAST25
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 157ExtracellularSequence analysis8
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 180CytoplasmicSequence analysis2
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 235ExtracellularSequence analysisAdd BLAST34
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 275CytoplasmicSequence analysisAdd BLAST19
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 321ExtracellularSequence analysisAdd BLAST25
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 385CytoplasmicSequence analysisAdd BLAST43
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 411ExtracellularSequence analysis5
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 437CytoplasmicSequence analysis5
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 504ExtracellularSequence analysisAdd BLAST46
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Topological domaini526 – 618CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000148942

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134873929

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC5A12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189046187

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003376801 – 618Sodium-coupled monocarboxylate transporter 2Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1EHB4

PeptideAtlas

More...
PeptideAtlasi
Q1EHB4

PRoteomics IDEntifications database

More...
PRIDEi
Q1EHB4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61209
61210 [Q1EHB4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q1EHB4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q1EHB4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148942 Expressed in 87 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1EHB4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q1EHB4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060904

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127745, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379326

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2349 Eukaryota
COG0591 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159545

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261662

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1EHB4

KEGG Orthology (KO)

More...
KOi
K14388

Identification of Orthologs from Complete Genome Data

More...
OMAi
AIADTWY

Database of Orthologous Groups

More...
OrthoDBi
1180002at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1EHB4

TreeFam database of animal gene trees

More...
TreeFami
TF316728

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00474 SSF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00813 sss, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50283 NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q1EHB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVKNFAVWD YVVFAALFFI SSGIGVFFAI KERKKATSRE FLVGGRQMSF
60 70 80 90 100
GPVGLSLTAS FMSAVTVLGT PSEVYRFGAS FLVFFIAYLF VILLTSELFL
110 120 130 140 150
PVFYRSGITS TYEYLQLRFN KPVRYAATVI YIVQTILYTG VVVYAPALAL
160 170 180 190 200
NQVTGFDLWG SVFATGIVCT FYCTLGGLKA VVWTDAFQMV VMIVGFLTVL
210 220 230 240 250
IQGSTHAGGF HNVLEQSTNG SRLHIFDFDV DPLRRHTFWT ITVGGTFTWL
260 270 280 290 300
GIYGVNQSTI QRCISCKTEK HAKLALYFNL LGLWIILVCA VFSGLIMYSH
310 320 330 340 350
FKDCDPWTSG IISAPDQLMP YFVMEIFATM PGLPGLFVAC AFSGTLSTVA
360 370 380 390 400
SSINALATVT FEDFVKSCFP HLSDKLSTWI SKGLCLLFGV MCTSMAVAAS
410 420 430 440 450
VMGGVVQASL SIHGMCGGPM LGLFSLGIVF PFVNWKGALG GLLTGITLSF
460 470 480 490 500
WVAIGAFIYP APASKTWPLP LSTDQCIKSN VTATGPPVLS SRPGIADTWY
510 520 530 540 550
SISYLYYSAV GCLGCIVAGV IISLITGRQR GEDIQPLLIR PVCNLFCFWS
560 570 580 590 600
KKYKTLCWCG VQHDSGTEQE NLENGSARKQ GAESVLQNGL RRESLVHVPG
610
YDPKDKSYNN MAFETTHF
Length:618
Mass (Da):67,647
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01D5F954BD28EF6F
GO
Isoform 2 (identifier: Q1EHB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-396: LLFGVMCTSMA → RYSWWTFYSIS
     397-618: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):44,077
Checksum:i84BAB86B6E9A9F4A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLZ7E9PLZ7_HUMAN
Sodium-coupled monocarboxylate tran...
SLC5A12
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1E3G3V1E3_HUMAN
Sodium-coupled monocarboxylate tran...
SLC5A12 hCG_2036627
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti285I → V in AAQ73572 (Ref. 2) Curated1
Sequence conflicti396A → S in AAQ73572 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043703510V → L. Corresponds to variant dbSNP:rs12278761Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033994386 – 396LLFGVMCTSMA → RYSWWTFYSIS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_033995397 – 618Missing in isoform 2. 1 PublicationAdd BLAST222

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY299482 mRNA Translation: AAQ73572.1
AC083755 Genomic DNA No translation available.
BC049207 mRNA Translation: AAH49207.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7860.2 [Q1EHB4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_848593.2, NM_178498.3 [Q1EHB4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280467; ENSP00000280467; ENSG00000148942 [Q1EHB4-2]
ENST00000396005; ENSP00000379326; ENSG00000148942 [Q1EHB4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
159963

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:159963

UCSC genome browser

More...
UCSCi
uc001mra.3 human [Q1EHB4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299482 mRNA Translation: AAQ73572.1
AC083755 Genomic DNA No translation available.
BC049207 mRNA Translation: AAH49207.1
CCDSiCCDS7860.2 [Q1EHB4-1]
RefSeqiNP_848593.2, NM_178498.3 [Q1EHB4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127745, 2 interactors
STRINGi9606.ENSP00000379326

Protein family/group databases

TCDBi2.A.21.5.6 the solute:sodium symporter (sss) family

PTM databases

iPTMnetiQ1EHB4
PhosphoSitePlusiQ1EHB4

Polymorphism and mutation databases

BioMutaiSLC5A12
DMDMi189046187

Proteomic databases

PaxDbiQ1EHB4
PeptideAtlasiQ1EHB4
PRIDEiQ1EHB4
ProteomicsDBi61209
61210 [Q1EHB4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280467; ENSP00000280467; ENSG00000148942 [Q1EHB4-2]
ENST00000396005; ENSP00000379326; ENSG00000148942 [Q1EHB4-1]
GeneIDi159963
KEGGihsa:159963
UCSCiuc001mra.3 human [Q1EHB4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
159963

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC5A12

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0026178
HGNCiHGNC:28750 SLC5A12
HPAiHPA060904
MIMi612455 gene
neXtProtiNX_Q1EHB4
OpenTargetsiENSG00000148942
PharmGKBiPA134873929

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00940000159545
HOGENOMiHOG000261662
InParanoidiQ1EHB4
KOiK14388
OMAiAIADTWY
OrthoDBi1180002at2759
PhylomeDBiQ1EHB4
TreeFamiTF316728

Enzyme and pathway databases

ReactomeiR-HSA-427601 Multifunctional anion exchangers

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
159963

Protein Ontology

More...
PROi
PR:Q1EHB4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148942 Expressed in 87 organ(s), highest expression level in intestine
ExpressionAtlasiQ1EHB4 baseline and differential
GenevisibleiQ1EHB4 HS

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS50283 NA_SOLUT_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC5AC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1EHB4
Secondary accession number(s): Q86UC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 8, 2019
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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