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Protein

Tumor necrosis factor, alpha-induced protein 8-like protein 2 A

Gene

tnfaip8l2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-DRE-1483255 PI Metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor, alpha-induced protein 8-like protein 2 A
Short name:
TIPE2 A
Short name:
TNF alpha-induced protein 8-like protein 2 A
Short name:
TNFAIP8-like protein 2 A
Gene namesi
ORF Names:si:dkey-24a7.9, zgc:136816
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-060616-38 tnfaip8l2a

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003693971 – 186Tumor necrosis factor, alpha-induced protein 8-like protein 2 AAdd BLAST186

Proteomic databases

PaxDbiQ1ECV8

Expressioni

Gene expression databases

BgeeiENSDARG00000075592

Structurei

3D structure databases

SMRiQ1ECV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).By similarity

Sequence similaritiesi

Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IGTQ Eukaryota
ENOG4111INB LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
InParanoidiQ1ECV8
OMAiRNNQFSE
OrthoDBiEOG091G0O34
PhylomeDBiQ1ECV8
TreeFamiTF323415

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

Sequencei

Sequence statusi: Complete.

Q1ECV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAFSSKDMA MQAQKKILSR MASKSVAQMF IDDNSSEVLD ELYRVSKEHS
60 70 80 90 100
GNRAEAQKVV KNMIKIAVKV GVLFRHEKFS AEELSIAQEF RKKLHHGAMT
110 120 130 140 150
AISFQEVEFT FDKSVMINLL SDCRDLLLKL VEKHLTPKSL DRIRHVFNHY
160 170 180
SNPELLTHLY DPQGNLWSNL SKICSGLNRM IEEGKL
Length:186
Mass (Da):21,355
Last modified:July 11, 2006 - v1
Checksum:iA45E633F36085D14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU571385 Genomic DNA Translation: CAX13646.1
BC117652 mRNA Translation: AAI17653.1
RefSeqiNP_001038766.1, NM_001045301.1
UniGeneiDr.825

Genome annotation databases

EnsembliENSDART00000102725; ENSDARP00000093501; ENSDARG00000075592
GeneIDi723996
KEGGidre:723996

Similar proteinsi

Entry informationi

Entry nameiTPL2A_DANRE
AccessioniPrimary (citable) accession number: Q1ECV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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