Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronUniRule annotation1
Metal bindingi58IronUniRule annotation1
Metal bindingi128IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAutoinducer synthesis, Quorum sensing
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
Alternative name(s):
AI-2 synthesis proteinUniRule annotation
Autoinducer-2 production protein LuxSUniRule annotation
Gene namesi
Name:luxSUniRule annotation
Ordered Locus Names:YPN_0794
ORF Names:YP516_0851
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000008936 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002980591 – 171S-ribosylhomocysteine lyaseAdd BLAST171

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1CLK4
SMRiQ1CLK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040371
KOiK07173
OMAiAIHTLEH

Family and domain databases

Gene3Di3.30.1360.80, 1 hit
HAMAPiMF_00091 LuxS, 1 hit
InterProiView protein in InterPro
IPR037005 LuxS_sf
IPR011249 Metalloenz_LuxS/M16
IPR003815 S-ribosylhomocysteinase
PANTHERiPTHR35799 PTHR35799, 1 hit
PfamiView protein in Pfam
PF02664 LuxS, 1 hit
PIRSFiPIRSF006160 AI2, 1 hit
PRINTSiPR01487 LUXSPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172 S-ribosylhomocysteinase, 1 hit
SUPFAMiSSF63411 SSF63411, 1 hit

Sequencei

Sequence statusi: Complete.

Q1CLK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLDSFTVD HTIMKAPAVR VAKTMKTPHG DEITVFDLRF CVPNKEVMPE
60 70 80 90 100
KGIHTLEHLF AGFMRDHLNG DGVEIIDISP MGCRTGFYMS LIGTPDEQRV
110 120 130 140 150
ADAWKAAMAD VLKVTDQRKI PELNEYQCGT YHMHSLEEAQ SIAKDILDRD
160 170
VRINHNEELA LPKEKLTELH I
Length:171
Mass (Da):19,396
Last modified:July 11, 2006 - v1
Checksum:iB46F3D9BD23663E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA Translation: ABG17126.1
ACNQ01000007 Genomic DNA Translation: EEO77993.1
RefSeqiWP_002209453.1, NZ_ACNQ01000007.1

Genome annotation databases

EnsemblBacteriaiABG17126; ABG17126; YPN_0794
EEO77993; EEO77993; YP516_0851
KEGGiypn:YPN_0794

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA Translation: ABG17126.1
ACNQ01000007 Genomic DNA Translation: EEO77993.1
RefSeqiWP_002209453.1, NZ_ACNQ01000007.1

3D structure databases

ProteinModelPortaliQ1CLK4
SMRiQ1CLK4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG17126; ABG17126; YPN_0794
EEO77993; EEO77993; YP516_0851
KEGGiypn:YPN_0794

Phylogenomic databases

HOGENOMiHOG000040371
KOiK07173
OMAiAIHTLEH

Family and domain databases

Gene3Di3.30.1360.80, 1 hit
HAMAPiMF_00091 LuxS, 1 hit
InterProiView protein in InterPro
IPR037005 LuxS_sf
IPR011249 Metalloenz_LuxS/M16
IPR003815 S-ribosylhomocysteinase
PANTHERiPTHR35799 PTHR35799, 1 hit
PfamiView protein in Pfam
PF02664 LuxS, 1 hit
PIRSFiPIRSF006160 AI2, 1 hit
PRINTSiPR01487 LUXSPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172 S-ribosylhomocysteinase, 1 hit
SUPFAMiSSF63411 SSF63411, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLUXS_YERPN
AccessioniPrimary (citable) accession number: Q1CLK4
Secondary accession number(s): C4GPY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 11, 2006
Last modified: October 10, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again