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Protein

Acetate kinase

Gene

ackA

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (YPN_2159)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10MagnesiumUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Active sitei150Proton donor/acceptorUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1
Sitei243Transition state stabilizerUniRule annotation1
Metal bindingi387MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 214ATPUniRule annotation5
Nucleotide bindingi285 – 287ATPUniRule annotation3
Nucleotide bindingi333 – 337ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:YPN_2158
ORF Names:YP516_2412
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000008936 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022861 – 400Acetate kinaseAdd BLAST400

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1CHP3
SMRiQ1CHP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398
KOiK00925
OMAiWKALTGT

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1CHP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKLVLVLN CGSSSLKFAI IDATNGEEHI SGLAECFHLP EARIKWKVDG
60 70 80 90 100
GKQEAALGAG AAHSEALNFI VNTILAQKPA LSAQLTAIGH RIVHGGEKFT
110 120 130 140 150
SSVIVTEDVI QGIKDSIPFA PLHNPAHLIG IAEALKSFPN LADKNVAVFD
160 170 180 190 200
TAFHQTMPEE SYLYALPYSL YKDHGIRRYG AHGTSHFYVS QEAAKILNKP
210 220 230 240 250
LEELNVITCH LGNGGSVTAV RNGKCVDTSM GLTPLEGLVM GTRSGDLDPA
260 270 280 290 300
IIFHLHDAMG MSVDQINTLL TKESGLLGLT EVTSDCRYVE DNYATKADAK
310 320 330 340 350
RAMDVFCHRL AKYIGSYTAL MDGRLDAVVF TGGIGENAAM VRELTLDKLG
360 370 380 390 400
LLGFEIDHER NMAARFGKSG TITKDSSRLA LVIPTNEELV IAQDAARLTA
Length:400
Mass (Da):43,018
Last modified:July 11, 2006 - v1
Checksum:i21BA6CC5B1A2F716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA Translation: ABG18487.1
ACNQ01000013 Genomic DNA Translation: EEO76215.1
RefSeqiWP_002210288.1, NZ_ACNQ01000013.1

Genome annotation databases

EnsemblBacteriaiABG18487; ABG18487; YPN_2158
EEO76215; EEO76215; YP516_2412
KEGGiypn:YPN_2158

Similar proteinsi

Entry informationi

Entry nameiACKA_YERPN
AccessioniPrimary (citable) accession number: Q1CHP3
Secondary accession number(s): C4GV87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: June 7, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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