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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi11Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi14Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi87Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei212S-adenosyl-L-methionineUniRule annotation1
Binding sitei241S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei262S-adenosyl-L-methionineUniRule annotation1
Binding sitei307S-adenosyl-L-methionineUniRule annotation1
Active sitei334NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Synonyms:rumB
Ordered Locus Names:YPN_2644
ORF Names:YP516_2983
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000008936 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002820231 – 37623S rRNA (uracil(747)-C(5))-methyltransferase RlmCAdd BLAST376

Structurei

3D structure databases

ProteinModelPortaliQ1CGA8
SMRiQ1CGA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218547
KOiK03212
OMAiSCQWLEK

Family and domain databases

HAMAPiMF_01012 23SrRNA_methyltr_RlmC, 1 hit
InterProiView protein in InterPro
IPR001566 23S_rRNA_MeTrfase_RlmD
IPR011825 23SrRNA_MeTrfase_RlmC
IPR030390 MeTrfase_TrmA_AS
IPR030391 MeTrfase_TrmA_CS
IPR029063 SAM-dependent_MTases
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02085 meth_trns_rumB, 1 hit
TIGR00479 rumA, 1 hit
PROSITEiView protein in PROSITE
PS51687 SAM_MT_RNA_M5U, 1 hit
PS01230 TRMA_1, 1 hit
PS01231 TRMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1CGA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCAQYTAGR CRSCQWLDKP YPQQLADKQH HLESLLAGHA VTQWLAPVFG
60 70 80 90 100
RESAFRNKAK MVVSGSVERP LLGMLHRDGT PVDLCACPLY PPSFEPVFTV
110 120 130 140 150
LKTFIARAGL TPYNVARKRG ELKFLLLTES TYNGELMLRF VLRSETKLAQ
160 170 180 190 200
LIAALPWLQQ QLPQLAVISA NIQPVHMAIL EGEREIPLTE QQALPERFNQ
210 220 230 240 250
VPLYIRPQSF FQTNPQVAAS LYATARQWVQ EHEVHSMWDL FCGVGGFGLH
260 270 280 290 300
CAGPETQLTG IEINAEAIAC ARQSAEQLGL KNVSFAALDS TRFATAEAQI
310 320 330 340 350
PELVLVNPPR RGIGRELCDY LSQMAPKFIL YSSCNAETMA KDISLLAGYH
360 370
IERVQLFDMF PHTSHYEVLT LLTLRR
Length:376
Mass (Da):42,202
Last modified:July 11, 2006 - v1
Checksum:iEE0FB4775CE9BB44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA Translation: ABG18972.1
ACNQ01000017 Genomic DNA Translation: EEO75097.1
RefSeqiWP_002208756.1, NZ_ACNQ01000017.1

Genome annotation databases

EnsemblBacteriaiABG18972; ABG18972; YPN_2644
EEO75097; EEO75097; YP516_2983
KEGGiypn:YPN_2644

Similar proteinsi

Entry informationi

Entry nameiRLMC_YERPN
AccessioniPrimary (citable) accession number: Q1CGA8
Secondary accession number(s): C4GVZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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