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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:YPA_2437
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000001971 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000099671 – 228Uracil-DNA glycosylaseAdd BLAST228

Proteomic databases

PRIDEiQ1C570

Structurei

3D structure databases

ProteinModelPortaliQ1C570
SMRiQ1C570
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q1C570-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPSLTWHDV IGQEKEQPYF KDTLAYVAAE RRAGKTIYPP QKDIFNAFRL
60 70 80 90 100
TELDQVKVVI LGQDPYHGPN QAHGLSFSVL PGVPAPPSLG NIYKELVTDI
110 120 130 140 150
PGFQRPNHGF LQSWAEQGVL LLNTVLTVEA GKAHSHANLG WETFTDKVIA
160 170 180 190 200
ALNEHREGVI FMLWGSHAQK KGRIINTERH YILKAPHPSP LSAHRGFLGC
210 220
KHFSQANQLL QQQNQQPIDW QPKLPAVE
Length:228
Mass (Da):25,559
Last modified:July 11, 2006 - v1
Checksum:i11AF559C5513B6BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA Translation: ABG14402.1
RefSeqiWP_002209663.1, NZ_CP009906.1

Genome annotation databases

EnsemblBacteriaiABG14402; ABG14402; YPA_2437
KEGGiypa:YPA_2437

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA Translation: ABG14402.1
RefSeqiWP_002209663.1, NZ_CP009906.1

3D structure databases

ProteinModelPortaliQ1C570
SMRiQ1C570
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ1C570

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG14402; ABG14402; YPA_2437
KEGGiypa:YPA_2437

Phylogenomic databases

HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUNG_YERPA
AccessioniPrimary (citable) accession number: Q1C570
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: October 10, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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