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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:Mmcs_2069
OrganismiMycobacterium sp. (strain MCS)
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003255041 – 516Probable malate:quinone oxidoreductaseAdd BLAST516

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379
KOiK00116
OMAiPHLDTRW

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

Q1BAA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDAQVAKTD VVLVGAGIMS ATLSALIKLL EPNWSITLIE RLDGAAAESS
60 70 80 90 100
DPWNNAGTGH SALCELNYTP EGPGGSIDIT KAVHVNEQFQ VSRQFWTYAV
110 120 130 140 150
ENGVLPDVRN FINPIPHVSF VSGARNVEYL RARYDALVPN PLFATMEYID
160 170 180 190 200
DRDEFARRLP FMADKRDFRE PVALNWSQDG TDIDFGSLSR QLIGYTAQRG
210 220 230 240 250
MTTLFGHEVR DLDKQSDGSW SVKVVNRRTG AKRKLNAKFV FVGAGGGALP
260 270 280 290 300
LLQKAGIEEA KGFGGFPVGG QWLRTGNPEL TARHQAKVYG MPPLGAPPMS
310 320 330 340 350
VPHLDTRVIN GKSWLLFGPF AGWSPKFLKQ GKVTDLPFSV KPNNLASMLG
360 370 380 390 400
VGLTEMGLLK YLIGQLLLSE ADRVETLRNF APSARDSDWE LDIAGQRVQV
410 420 430 440 450
IRRKGKGGVL EFGTTVLAAK DGSIAGLLGA SPGASTAVPA MLDVMERCFG
460 470 480 490 500
DRYTAWLPKL KEIVPSLGTK LSDEPKLFQE IWAHGTKVLK LDHPAAGLPV
510
AGTDTEHREP ATTVTA
Length:516
Mass (Da):56,003
Last modified:July 11, 2006 - v1
Checksum:iEEC9685C404ACFEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA Translation: ABG08177.1
RefSeqiWP_011559467.1, NC_008146.1

Genome annotation databases

EnsemblBacteriaiABG08177; ABG08177; Mmcs_2069
GeneIDi32422641
KEGGimmc:Mmcs_2069

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA Translation: ABG08177.1
RefSeqiWP_011559467.1, NC_008146.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG08177; ABG08177; Mmcs_2069
GeneIDi32422641
KEGGimmc:Mmcs_2069

Phylogenomic databases

HOGENOMiHOG000109379
KOiK00116
OMAiPHLDTRW

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01008

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMQO_MYCSS
AccessioniPrimary (citable) accession number: Q1BAA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 11, 2006
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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