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UniProtKB - Q1B6A7 (MBTB_MYCSS)
Protein
Phenyloxazoline synthase MbtB
Gene
mbtB
Organism
Mycobacterium sp. (strain MCS)
Status
Functioni
Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores (By similarity).
By similarityCofactori
pantetheine 4'-phosphateBy similarityNote: Binds 2 phosphopantetheines covalently.By similarity
: mycobactin biosynthesis Pathwayi
This protein is involved in the pathway mycobactin biosynthesis, which is part of Siderophore biosynthesis.View all proteins of this organism that are known to be involved in the pathway mycobactin biosynthesis and in Siderophore biosynthesis.
GO - Molecular functioni
- ligase activity Source: UniProtKB-KW
- phosphopantetheine binding Source: InterPro
GO - Biological processi
- metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase, Multifunctional enzyme |
Enzyme and pathway databases
UniPathwayi | UPA00011 |
Names & Taxonomyi
Protein namesi | Recommended name: Phenyloxazoline synthase MbtB (EC:6.3.2.-)Alternative name(s): Mycobactin synthetase protein B |
Gene namesi | Name:mbtB Ordered Locus Names:Mmcs_3470 |
Organismi | Mycobacterium sp. (strain MCS) |
Taxonomic identifieri | 164756 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › unclassified Mycobacterium |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261308 | 1 – 1167 | Phenyloxazoline synthase MbtBAdd BLAST | 1167 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 39 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 | |
Modified residuei | 1089 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Post-translational modificationi
4'-phosphopantetheine is transferred from CoA to a specific serine in each of the two carrier protein domains, leading to their activation from apo to holo forms.By similarity
Keywords - PTMi
Phosphopantetheine, PhosphoproteinFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 78 | Carrier 1PROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 1054 – 1130 | Carrier 2PROSITE-ProRule annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 78 – 100 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 98 – 390 | Condensation/cyclizationAdd BLAST | 293 | |
Regioni | 575 – 967 | AdenylationAdd BLAST | 393 |
Domaini
Modular protein that contains an aryl carrier protein (ArCP) domain which bears a phosphopantetheinyl arm to attach the activated salicylic acid, a condensation/cyclization domain involved in the formation of the oxazoline ring, an adenylation domain which activates the serine or threonine residue into an aminoacyl-AMP ester, and a peptidyl carrier protein (PCP) domain which bears a phosphopantetheinyl arm to attach the activated serine or threonine.By similarity
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
HOGENOMi | CLU_000022_2_4_11 |
OMAi | MNTVEFI |
Family and domain databases
Gene3Di | 1.10.1200.10, 2 hits 3.30.300.30, 1 hit 3.30.559.10, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit PF00668, Condensation, 1 hit PF00550, PP-binding, 2 hits |
SMARTi | View protein in SMART SM00823, PKS_PP, 2 hits |
SUPFAMi | SSF47336, SSF47336, 2 hits |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit PS50075, CARRIER, 2 hits PS00012, PHOSPHOPANTETHEINE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q1B6A7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAVVTSSQT VRAEVAELLG IEESALDPDA DLIASGLDSI RMMSLSGRWR
60 70 80 90 100
KQGIDVRFAA MAANPTVAAW TRLVGERTAE SPGAATQSGD TAASAGDPDA
110 120 130 140 150
PFPLAPIQHA LWVGRNELTE LGGVAAHLYV EFDGAGVDPE RLRTAAAALA
160 170 180 190 200
ARHPMLRVDI LGDGMQRISD RDLPVKVTDL RHLDVADAEQ QLEVIRHAKS
210 220 230 240 250
HQLLEGEVLE LALTLLPDGR TRLHVDLDMQ AADAVSYRNF MADLAALYRG
260 270 280 290 300
AQLPELQYTY RQYRSAFTAT PAPTVDEDRR WWTERIPDLP EPPALPLVPR
310 320 330 340 350
AEQRDPRRGT RRWHFLDTDI RDRLFAAARA RGITPAMAFA ASYAGTLARW
360 370 380 390 400
STSRHFLLNL PMFGREPFHP DVDKLVGDFT SSLMLDVDFT EAHTPAQRAR
410 420 430 440 450
VMQEALHTSA EHATYSGLSV LRDLSRHHGS PSLAPFVFTS ALGLGDLFAG
460 470 480 490 500
DVTDQFGTPV WHISQGPQVL LDAQVTPFDG GLLVNWDVRE DAFRPGVIDA
510 520 530 540 550
MFAYQLAELE RLAADDAAWD AADPPAVPPA QRAVRDAVND TGARRSDDAL
560 570 580 590 600
HDGFFRTAAH TPDATAVIGS TGTLTYAELR ERVLAVTGAL QVAGIKPGDT
610 620 630 640 650
VAVMGPKCAD QVTALLAIHA AGAVYVPIGA DQPADRADSI LQTAGVRMAL
660 670 680 690 700
ACGDEPPTFL PALTIAEAVR VGSRVHGVTP ATVEPDRVAY VLFTSGSTGA
710 720 730 740 750
PKGVEVTHAA AMNTLEFIND HFGIGPSDRS LALSTLEGDL SVLDVFGMLR
760 770 780 790 800
AGGSLVVVDE AQRRDPDSWA RLIAEHSVTV LHWMPGWLEM LLEVGGALPS
810 820 830 840 850
VRVVPTGGDW VRTEMVRELR RAAPGVRFAG LGGATETAIH NTICEPGELP
860 870 880 890 900
REWSAVPFGR PLPNNACRVV AADGADCPDW VPGELWVGGR GIARGYRGRP
910 920 930 940 950
DLTAERFVVH DGRTWYRTGD LVRYLPDGQI DFVGRADHRV KISGYRIELG
960 970 980 990 1000
EVEAALRRIA GVEAAVAAVL TAPGDGRGEQ LAAIVRASSP AVTVDELTRR
1010 1020 1030 1040 1050
MAELVPPHMV PSHIALVEAV PFTVGGKIDR RAVTAELTRS MAERANAQAP
1060 1070 1080 1090 1100
TYRVPSTALE RALADIVSTV LDRDSVGADD DFFELGGDSV LATQAVARIR
1110 1120 1130 1140 1150
EWLDSPGVMV TDIFAARRVG ALARRLVDHE SGSDRLEGVA ELYLEVADMN
1160
SADVASALHS TSAQASR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000384 Genomic DNA Translation: ABG09577.1 |
Genome annotation databases
KEGGi | mmc:Mmcs_3470 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000384 Genomic DNA Translation: ABG09577.1 |
3D structure databases
AlphaFoldDBi | Q1B6A7 |
SMRi | Q1B6A7 |
ModBasei | Search... |
Genome annotation databases
KEGGi | mmc:Mmcs_3470 |
Phylogenomic databases
HOGENOMi | CLU_000022_2_4_11 |
OMAi | MNTVEFI |
Enzyme and pathway databases
UniPathwayi | UPA00011 |
Family and domain databases
Gene3Di | 1.10.1200.10, 2 hits 3.30.300.30, 1 hit 3.30.559.10, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR020806, PKS_PP-bd IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit PF00668, Condensation, 1 hit PF00550, PP-binding, 2 hits |
SMARTi | View protein in SMART SM00823, PKS_PP, 2 hits |
SUPFAMi | SSF47336, SSF47336, 2 hits |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit PS50075, CARRIER, 2 hits PS00012, PHOSPHOPANTETHEINE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MBTB_MYCSS | |
Accessioni | Q1B6A7Primary (citable) accession number: Q1B6A7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | July 11, 2006 | |
Last modified: | May 25, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families