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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei591ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:G1G6P-3244-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Rxyl_3202
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteriaRubrobacteralesRubrobacteraceaeRubrobacter
Proteomesi
  • UP000006637 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348081 – 817Leucine--tRNA ligaseAdd BLAST817

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_3202

Structurei

3D structure databases

ProteinModelPortaliQ1AR71
SMRiQ1AR71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 61"HIGH" regionAdd BLAST11
Motifi588 – 592"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q1AR71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETFAKRAS RRGYDPRAIE ERWQRRWAET GLYKTDEDPS KPKHYALTML
60 70 80 90 100
PYPSGDLHVG HWYAMTPSDT RARFMRMRGY RVFFPIGFDA FGLPAENAAI
110 120 130 140 150
KRGIHPRDWT YSNIERMRGQ LRQMGTMFDF DAEVVTCDPE YYRWNQWFFL
160 170 180 190 200
KFYEKGLAYR EKAPVDWCPS CNTTLAREQV VGPDRRCERC DTPVIKRNLA
210 220 230 240 250
QWLFKITDYA EELLDFSEIE WPERVKALQR NWIGRSEGAE IEFEIEGYGG
260 270 280 290 300
VTVFTTRPDT LFGATFFVVA PEHPAVESIT TPERGEEVRA YVERAARMSE
310 320 330 340 350
IDRADVTREK TGVFTGAYAV NPANGERIPV YVADYVLMGY GTGAIMAVPA
360 370 380 390 400
HDERDFEFAK KHGIEIRTVI APPDWDGSPL ERAYVGEGQM VNSGPFDGTP
410 420 430 440 450
SAEGREKVTG WLRERGVGRP AVNYRLRDWL ISRQRYWGTP IPIVYCERCG
460 470 480 490 500
TVPVPEEDLP VLLPEDAEFM PTGESPLKFN DEFRKTECPR CGGPAERETD
510 520 530 540 550
TMDTFVDSSW YQYRYLSPHY EEGPFDPERG SRWLPVDQYT GGIEHATMHL
560 570 580 590 600
LYTRFFTKVM RDLGLVDFDE PMLRLFNQGV ILGPDGNRMS KSRGNVVNPQ
610 620 630 640 650
EYVDRYGSDV LRCYLMFIGP WDEGGPWDPG GIEGVARWLR RAFTLVAGGD
660 670 680 690 700
VSEAEADPGE LSRRTHRLVK RVTEYLEGFR FNTAIAALME HTNYLLAVKG
710 720 730 740 750
EVGEEEWREA MRSFLLVLAP FAPHHAEEMW EILGEEYSVH EQGWPSWDEE
760 770 780 790 800
LVREETVTLV VQVNGKLRDR VEAPAGVDEG RARELALSSE RVRAHVEGRE
810
LRKTVYVPGR LINLVVS
Length:817
Mass (Da):93,833
Last modified:July 11, 2006 - v1
Checksum:iFDE42442A52BC7CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA Translation: ABG06107.1
RefSeqiWP_011566112.1, NC_008148.1

Genome annotation databases

EnsemblBacteriaiABG06107; ABG06107; Rxyl_3202
KEGGirxy:Rxyl_3202

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA Translation: ABG06107.1
RefSeqiWP_011566112.1, NC_008148.1

3D structure databases

ProteinModelPortaliQ1AR71
SMRiQ1AR71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266117.Rxyl_3202

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG06107; ABG06107; Rxyl_3202
KEGGirxy:Rxyl_3202

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Enzyme and pathway databases

BioCyciRXYL266117:G1G6P-3244-MONOMER

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_RUBXD
AccessioniPrimary (citable) accession number: Q1AR71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 11, 2006
Last modified: October 10, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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Main funding by: National Institutes of Health

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