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Entry version 80 (02 Jun 2021)
Sequence version 1 (11 Jul 2006)
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Protein

Anion exchange protein

Gene

NBC

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transportUniRule annotationARBA annotation, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.31.2.16, the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NBCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaCamarodontaEchinideaStrongylocentrotidaeStrongylocentrotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007110 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei546 – 568HelicalUniRule annotationAdd BLAST23
Transmembranei580 – 609HelicalUniRule annotationAdd BLAST30
Transmembranei629 – 647HelicalUniRule annotationAdd BLAST19
Transmembranei746 – 764HelicalUniRule annotationAdd BLAST19
Transmembranei776 – 796HelicalUniRule annotationAdd BLAST21
Transmembranei832 – 851HelicalUniRule annotationAdd BLAST20
Transmembranei872 – 897HelicalUniRule annotationAdd BLAST26
Transmembranei1005 – 1022HelicalUniRule annotationAdd BLAST18
Transmembranei1028 – 1045HelicalUniRule annotationAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7668.SPU_025514-tr

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 465Band_3_cytoInterPro annotationAdd BLAST314
Domaini512 – 1011HCO3_cotranspInterPro annotationAdd BLAST500

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 94DisorderedSequence analysisAdd BLAST94
Regioni224 – 244DisorderedSequence analysisAdd BLAST21
Regioni256 – 326DisorderedSequence analysisAdd BLAST71
Regioni486 – 510DisorderedSequence analysisAdd BLAST25
Regioni1139 – 1214DisorderedSequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 63Basic residuesSequence analysisAdd BLAST19
Compositional biasi64 – 81Polar residuesSequence analysisAdd BLAST18
Compositional biasi225 – 239Basic residuesSequence analysisAdd BLAST15
Compositional biasi256 – 319Polar residuesSequence analysisAdd BLAST64
Compositional biasi490 – 510Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1142 – 1156Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002289_5_1_1

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.930.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453, PTHR11453, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804, SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834, ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1A708-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDESDVVVDQ GNYHSLREAD ESETSGHHAI YVGVHVPHNE EQQQKNHHHH
60 70 80 90 100
HHKHRHKGKS KKNGSSHSSA NNSSSTADAF FPNNDPDARP DALLLDKNGD
110 120 130 140 150
ASQRVKFILG DEADDGHESH EIFTEMEELC YGSDGEELEW KEMARWIKYE
160 170 180 190 200
EDVDVDADRW SKPHVATLPL HSLFELRTCL INGTVCLDME ADNIVQIADL
210 220 230 240 250
VLDKLIMSEQ LDESKREQVR EALLRKHHHQ SHKKHRDKRG SSLLPMIRSL
260 270 280 290 300
TDIGRSLSQG GAHNTSMEQQ AAAQSGIQTS HGSSPNIQNS QTSPSSLMVK
310 320 330 340 350
GNSGDLGKSE TSGSLPKVSS HHSLKKRLSE ARLSIPHNLA GHSLSARHSF
360 370 380 390 400
MRKIPQGAEA SNVLIGEVDF LSRPIIAFVR LQSAVSLGDP TEVPIPRRFL
410 420 430 440 450
FILLGPQSGE TKRYHEIGRC VATIMSDKVF HDVAYKAKST KDLLAGIDEF
460 470 480 490 500
IDSVTVLPPG AWDPNIRIEP PKVVPDQAKR LSHFQTPNGH AEGIDEEDGG
510 520 530 540 550
GGGGHNGEHE GLERTGKIFG GLIQDCKRRF PFYLSDFKDA FHLQCLASFI
560 570 580 590 600
FMYFACITPV ITFGGLLGEA TENRMSALEG LLGASICGVA FHLFSGQPLT
610 620 630 640 650
ILGSTGPILV YEKILFGFCK TQELDYLSFR FWIGLWTMVF CVILVATDAS
660 670 680 690 700
SFVKYFTRFI EESFSSLISF IFIYESVHKL MKIYKEYPVA RYANDNTTYE
710 720 730 740 750
CMCQTATGLF EYDEKDFYTE SKIDCDSLNG TLVGNWCGKH VPQSDIFFMS
760 770 780 790 800
LILMLGTFTI AYSLKEFKTT GYFPTIIRTT VSDFAVLIAV VIMVGVDRLF
810 820 830 840 850
GVDTPKLLVP SEFKPTSDLR KGWFIHPFNG NGWWTVLAAI IPALLATILV
860 870 880 890 900
FMDQQITAVI VNRKENKFKK GLGYHLDLLV VAVMLGICSI MGLPWFVAAT
910 920 930 940 950
VLSINHVNSL RVESECKAPG ERPKIVGCRE QRVTGVMVFV MIGLATLMTK
960 970 980 990 1000
ILSYVPMPVL YGVFLFMGIA SLKGVQFVDR LSLFFMPLKY QPDYIYLRHV
1010 1020 1030 1040 1050
GIKKVYLFTF IQLMCLVVPM GIKSTDAAIV FPIMVLGMVV VRKLMDYVFT
1060 1070 1080 1090 1100
KQEVMMLDDV MPEMTKRAKH DRKKKQEEEV AACEQIKNIP GRVQVPLSDG
1110 1120 1130 1140 1150
NMLSIPVDKV EFHPEVACIN IPEDMAKTGV WKALAKNAEG GQVVHRKPHG
1160 1170 1180 1190 1200
KEKSSSGGRP NLDLPTIPGS PRESSYLETQ RGSIQEVRIE VPEQFRRTPS
1210
PPPTHIGTDN ETSV
Length:1,214
Mass (Da):135,480
Last modified:July 11, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DC79CF3AC650D37
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ291138 mRNA Translation: ABC00768.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073019.1, NM_001079551.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
GeneID_593565M_001079551; NP_001073019; GeneID_593565BC

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
593565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spu:593565

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ291138 mRNA Translation: ABC00768.1
RefSeqiNP_001073019.1, NM_001079551.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7668.SPU_025514-tr

Protein family/group databases

TCDBi2.A.31.2.16, the anion exchanger (ae) family

Genome annotation databases

EnsemblMetazoaiGeneID_593565M_001079551; NP_001073019; GeneID_593565BC
GeneIDi593565
KEGGispu:593565

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
593565

Phylogenomic databases

eggNOGiKOG1172, Eukaryota
HOGENOMiCLU_002289_5_1_1
OrthoDBi265068at2759

Family and domain databases

Gene3Di3.40.930.10, 2 hits
InterProiView protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT
SUPFAMiSSF55804, SSF55804, 1 hit
TIGRFAMsiTIGR00834, ae, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ1A708_STRPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1A708
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 2, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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