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Entry version 88 (13 Feb 2019)
Sequence version 1 (11 Jul 2006)
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Protein

IQ domain-containing protein J

Gene

IQCJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IQ domain-containing protein JCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQCJImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000214216.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32406 IQCJ

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611622 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q1A5X6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
654502

Open Targets

More...
OpenTargetsi
ENSG00000214216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485504

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IQCJ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121940648

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003156611 – 159IQ domain-containing protein JAdd BLAST159

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1A5X6

PeptideAtlas

More...
PeptideAtlasi
Q1A5X6

PRoteomics IDEntifications database

More...
PRIDEi
Q1A5X6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61199
61200 [Q1A5X6-2]
61201 [Q1A5X6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q1A5X6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q1A5X6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214216 Expressed in 33 organ(s), highest expression level in corpus callosum

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052835

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000402153

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q1A5X6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 67IQ1 PublicationAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0SC Eukaryota
ENOG410YSGH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000847

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082511

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1A5X6

Identification of Orthologs from Complete Genome Data

More...
OMAi
MNTFSDG

Database of Orthologous Groups

More...
OrthoDBi
1290403at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1A5X6

TreeFam database of animal gene trees

More...
TreeFami
TF336256

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029362 IQCJ-SCHIP1_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15157 IQCJ-SCHIP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform IQCJ-1 (identifier: Q1A5X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLEELKRLQ NPLEQVNDGK YSFENHQLAM DAENNIEKYP LNLQPLESKV
60 70 80 90 100
KIIQRAWREY LQRQEPLGKR SPSPPSVSSE KLSSSVSMNT FSDSSTPFAR
110 120 130 140 150
APVGKIHPYI SWRLQSPGDK LPGGRKVILL YLDQLARPTG FIHTLKEPQI

ERLGFLTLQ
Length:159
Mass (Da):18,226
Last modified:July 11, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EBF23B8E2161D3D
GO
Isoform IQCJ-2 (identifier: Q1A5X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-159: FARAPVGKIH...IERLGFLTLQ → VSVMFLFLCPDLTFN

Show »
Length:112
Mass (Da):12,920
Checksum:i9CB68D585A4920F4
GO
Isoform IQCJ-3 (identifier: Q1A5X6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-52: Missing.

Note: No experimental confirmation available.
Show »
Length:132
Mass (Da):15,107
Checksum:i2267A67EA99D93A3
GO
Isoform IQCJ-SCHIP1-1 (identifier: B3KU38-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry B3KU38.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.1 Publication
Length:563
Mass (Da):62,248
GO
Isoform IQCJ-SCHIP1-2 (identifier: B3KU38-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry B3KU38.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.1 Publication
Length:536
Mass (Da):59,129
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04325926 – 52Missing in isoform IQCJ-3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_03059798 – 159FARAP…FLTLQ → VSVMFLFLCPDLTFN in isoform IQCJ-2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ309553 mRNA Translation: ABC26018.1
DQ309554 mRNA Translation: ABC26019.1
AC092997 Genomic DNA No translation available.
AC092999 Genomic DNA No translation available.
AC107312 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78670.1
BC137464 mRNA Translation: AAI37465.1
BC137469 mRNA Translation: AAI37470.1
BC144658 mRNA Translation: AAI44659.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46946.1 [Q1A5X6-1]
CCDS46947.1 [Q1A5X6-2]
CCDS56290.1 [Q1A5X6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001036170.1, NM_001042705.2 [Q1A5X6-1]
NP_001036171.1, NM_001042706.2 [Q1A5X6-2]
NP_001184029.1, NM_001197100.1 [Q1A5X6-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.570685

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397832; ENSP00000380932; ENSG00000214216 [Q1A5X6-2]
ENST00000451172; ENSP00000402153; ENSG00000214216 [Q1A5X6-1]
ENST00000482126; ENSP00000418141; ENSG00000214216 [Q1A5X6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
654502

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:654502

UCSC genome browser

More...
UCSCi
uc003fco.4 human [Q1A5X6-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309553 mRNA Translation: ABC26018.1
DQ309554 mRNA Translation: ABC26019.1
AC092997 Genomic DNA No translation available.
AC092999 Genomic DNA No translation available.
AC107312 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78670.1
BC137464 mRNA Translation: AAI37465.1
BC137469 mRNA Translation: AAI37470.1
BC144658 mRNA Translation: AAI44659.1
CCDSiCCDS46946.1 [Q1A5X6-1]
CCDS46947.1 [Q1A5X6-2]
CCDS56290.1 [Q1A5X6-3]
RefSeqiNP_001036170.1, NM_001042705.2 [Q1A5X6-1]
NP_001036171.1, NM_001042706.2 [Q1A5X6-2]
NP_001184029.1, NM_001197100.1 [Q1A5X6-3]
UniGeneiHs.570685

3D structure databases

ProteinModelPortaliQ1A5X6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000402153

PTM databases

iPTMnetiQ1A5X6
PhosphoSitePlusiQ1A5X6

Polymorphism and mutation databases

BioMutaiIQCJ
DMDMi121940648

Proteomic databases

PaxDbiQ1A5X6
PeptideAtlasiQ1A5X6
PRIDEiQ1A5X6
ProteomicsDBi61199
61200 [Q1A5X6-2]
61201 [Q1A5X6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397832; ENSP00000380932; ENSG00000214216 [Q1A5X6-2]
ENST00000451172; ENSP00000402153; ENSG00000214216 [Q1A5X6-1]
ENST00000482126; ENSP00000418141; ENSG00000214216 [Q1A5X6-3]
GeneIDi654502
KEGGihsa:654502
UCSCiuc003fco.4 human [Q1A5X6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
654502
DisGeNETi654502
EuPathDBiHostDB:ENSG00000214216.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IQCJ

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0003811
HGNCiHGNC:32406 IQCJ
HPAiHPA052835
MIMi611622 gene
neXtProtiNX_Q1A5X6
OpenTargetsiENSG00000214216
PharmGKBiPA143485504

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0SC Eukaryota
ENOG410YSGH LUCA
GeneTreeiENSGT00390000000847
HOGENOMiHOG000082511
HOVERGENiHBG106631
InParanoidiQ1A5X6
OMAiMNTFSDG
OrthoDBi1290403at2759
PhylomeDBiQ1A5X6
TreeFamiTF336256

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IQCJ human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
654502

Protein Ontology

More...
PROi
PR:Q1A5X6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000214216 Expressed in 33 organ(s), highest expression level in corpus callosum

Family and domain databases

InterProiView protein in InterPro
IPR029362 IQCJ-SCHIP1_N
PfamiView protein in Pfam
PF15157 IQCJ-SCHIP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQCJ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1A5X6
Secondary accession number(s): B7ZMM2, B9EH97, Q1A5X5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: February 13, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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