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Protein

Endothelial cell-specific chemotaxis regulator

Gene

ECSCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.2 Publications

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Apoptosis, Chemotaxis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial cell-specific chemotaxis regulator
Alternative name(s):
Apoptosis regulator through modulating IAP expression
Short name:
ARIA
Endothelial cell-specific molecule 2
Gene namesi
Name:ECSCR
Synonyms:ECSM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000249751.3
HGNCiHGNC:35454 ECSCR
neXtProtiNX_Q19T08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 124ExtracellularSequence analysisAdd BLAST100
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 205CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi641700
OpenTargetsiENSG00000249751
PharmGKBiPA164718891

Polymorphism and mutation databases

DMDMi121940639

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000036501725 – 205Endothelial cell-specific chemotaxis regulatorAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198PhosphoserineBy similarity1

Post-translational modificationi

May be heavily O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ19T08
PeptideAtlasiQ19T08
PRIDEiQ19T08
ProteomicsDBi61198

PTM databases

iPTMnetiQ19T08
PhosphoSitePlusiQ19T08

Expressioni

Tissue specificityi

Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells.2 Publications

Gene expression databases

BgeeiENSG00000249751 Expressed in 182 organ(s), highest expression level in adrenal gland
GenevisibleiQ19T08 HS

Organism-specific databases

HPAiHPA063337

Interactioni

Subunit structurei

Interacts with FLNA. Interacts with the 20S proteasome subunit PSMA7.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi567392, 12 interactors
DIPiDIP-60344N
IntActiQ19T08, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ19T08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 138Poly-Val4

Sequence similaritiesi

Belongs to the ECSCR family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4RP Eukaryota
ENOG410Z78P LUCA
GeneTreeiENSGT00400000023549
InParanoidiQ19T08
OMAiLQGHHSQ
OrthoDBiEOG091G1786
PhylomeDBiQ19T08

Family and domain databases

InterProiView protein in InterPro
IPR026247 ECSCR
PANTHERiPTHR28602 PTHR28602, 1 hit
PfamiView protein in Pfam
PF15820 ECSCR, 1 hit
PRINTSiPR02069 ECCREGULATOR

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q19T08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTAGAMQLC WVILGFLLFR GHNSQPTMTQ TSSSQGGLGG LSLTTEPVSS
60 70 80 90 100
NPGYIPSSEA NRPSHLSSTG TPGAGVPSSG RDGGTSRDTF QTVPPNSTTM
110 120 130 140 150
SLSMREDATI LPSPTSETVL TVAAFGVISF IVILVVVVII LVGVVSLRFK
160 170 180 190 200
CRKSKESEDP QKPGSSGLSE SCSTANGEKD SITLISMKNI NMNNGKQSLS

AEKVL
Length:205
Mass (Da):21,295
Last modified:July 11, 2006 - v1
Checksum:i7CB22DEF4B6ADCAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69T → I in BAG65489 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ462572 mRNA Translation: ABE73209.1
EU025066 mRNA Translation: ABW05062.1
AK304726 mRNA Translation: BAG65489.1
BC146912 mRNA Translation: AAI46913.1
BC146913 mRNA Translation: AAI46914.1
CCDSiCCDS75317.1
RefSeqiNP_001071161.1, NM_001077693.3
NP_001280668.1, NM_001293739.1
UniGeneiHs.483538
Hs.570903

Genome annotation databases

EnsembliENST00000618155; ENSP00000479243; ENSG00000249751
GeneIDi641700
KEGGihsa:641700
UCSCiuc032vne.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ462572 mRNA Translation: ABE73209.1
EU025066 mRNA Translation: ABW05062.1
AK304726 mRNA Translation: BAG65489.1
BC146912 mRNA Translation: AAI46913.1
BC146913 mRNA Translation: AAI46914.1
CCDSiCCDS75317.1
RefSeqiNP_001071161.1, NM_001077693.3
NP_001280668.1, NM_001293739.1
UniGeneiHs.483538
Hs.570903

3D structure databases

ProteinModelPortaliQ19T08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi567392, 12 interactors
DIPiDIP-60344N
IntActiQ19T08, 3 interactors

PTM databases

iPTMnetiQ19T08
PhosphoSitePlusiQ19T08

Polymorphism and mutation databases

DMDMi121940639

Proteomic databases

PaxDbiQ19T08
PeptideAtlasiQ19T08
PRIDEiQ19T08
ProteomicsDBi61198

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618155; ENSP00000479243; ENSG00000249751
GeneIDi641700
KEGGihsa:641700
UCSCiuc032vne.2 human

Organism-specific databases

CTDi641700
DisGeNETi641700
EuPathDBiHostDB:ENSG00000249751.3
GeneCardsiECSCR
HGNCiHGNC:35454 ECSCR
HPAiHPA063337
neXtProtiNX_Q19T08
OpenTargetsiENSG00000249751
PharmGKBiPA164718891
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4RP Eukaryota
ENOG410Z78P LUCA
GeneTreeiENSGT00400000023549
InParanoidiQ19T08
OMAiLQGHHSQ
OrthoDBiEOG091G1786
PhylomeDBiQ19T08

Miscellaneous databases

ChiTaRSiECSCR human
GenomeRNAii641700
PROiPR:Q19T08

Gene expression databases

BgeeiENSG00000249751 Expressed in 182 organ(s), highest expression level in adrenal gland
GenevisibleiQ19T08 HS

Family and domain databases

InterProiView protein in InterPro
IPR026247 ECSCR
PANTHERiPTHR28602 PTHR28602, 1 hit
PfamiView protein in Pfam
PF15820 ECSCR, 1 hit
PRINTSiPR02069 ECCREGULATOR
ProtoNetiSearch...

Entry informationi

Entry nameiECSCR_HUMAN
AccessioniPrimary (citable) accession number: Q19T08
Secondary accession number(s): B4E3H7, C3RSF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 11, 2006
Last modified: September 12, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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