UniProtKB - Q19S50 (STAT3_PIG)
Signal transducer and activator of transcription 3
STAT3
Functioni
Miscellaneous
GO - Molecular functioni
- chromatin DNA binding Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- astrocyte differentiation Source: UniProtKB
- cellular response to leptin stimulus Source: UniProtKB
- cytokine-mediated signaling pathway Source: GO_Central
- defense response Source: GO_Central
- eating behavior Source: UniProtKB
- energy homeostasis Source: UniProtKB
- eye photoreceptor cell differentiation Source: UniProtKB
- glucose homeostasis Source: UniProtKB
- growth hormone receptor signaling pathway via JAK-STAT Source: UniProtKB
- inflammatory response Source: UniProtKB
- interleukin-6-mediated signaling pathway Source: UniProtKB
- leptin-mediated signaling pathway Source: UniProtKB
- phosphorylation Source: UniProtKB
- positive regulation of erythrocyte differentiation Source: UniProtKB
- positive regulation of Notch signaling pathway Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein import into nucleus Source: UniProtKB
- radial glial cell differentiation Source: UniProtKB
- receptor signaling pathway via JAK-STAT Source: GO_Central
- regulation of cell cycle Source: UniProtKB
- regulation of cell population proliferation Source: GO_Central
- regulation of feeding behavior Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- response to leptin Source: UniProtKB
- response to peptide hormone Source: GO_Central
- sexual reproduction Source: UniProtKB
- temperature homeostasis Source: UniProtKB
- T-helper 17 cell lineage commitment Source: UniProtKB
- T-helper 17 type immune response Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcription 3 |
Gene namesi | Name:STAT3 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity).By similarity
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000347216 | 2 – 770 | Signal transducer and activator of transcription 3Add BLAST | 769 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 601 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 601 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 615 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 615 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 631 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 631 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 685 | Allysine; alternateBy similarity | 1 | |
Modified residuei | 685 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 705 | Phosphotyrosine; by FER and PTK6By similarity | 1 | |
Modified residuei | 707 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 714 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 727 | Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCEBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q19S50 |
PeptideAtlasi | Q19S50 |
PRIDEi | Q19S50 |
PTM databases
iPTMneti | Q19S50 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSSSCG00000017403, Expressed in lung and 37 other tissues |
Interactioni
Subunit structurei
Forms a homodimer or a heterodimer with a related family member (at least STAT1).
Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1 (By similarity).
Interacts with IL23R in presence of IL23 (By similarity).
Interacts (via SH2 domain) with NLK.
Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity).
Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity).
Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity).
Interacts with ARL2BP; interaction is enhanced with ARL2 (By similarity).
Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear.
Interacts with BMX.
Interacts with ZIPK/DAPK3.
Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with PRKCE and promotes DNA binding activity of STAT3 (By similarity).
Interacts with STMN3, antagonizing its microtubule-destabilizing activity (By similarity).
Interacts with the 'Lys-129' acetylated form of BIRC5/survivin.
Interacts with FER.
Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain).
Interacts with INPP5F; the interaction is independent of STAT3 Tyr-705 phosphorylation status.
Interacts with FGFR4 (By similarity).
Interacts with OCAD1 (By similarity).
Interacts (unphosphorylated or phosphorylated at Ser-727) with PHB (By similarity).
Interacts and may form heterodimers with NHLH1 (By similarity).
By similarityGO - Molecular functioni
- protein dimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000018439 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 580 – 670 | SH2PROSITE-ProRule annotationAdd BLAST | 91 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 150 – 162 | Essential for nuclear importBy similarityAdd BLAST | 13 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG3667, Eukaryota |
HOGENOMi | CLU_014189_3_0_1 |
InParanoidi | Q19S50 |
OrthoDBi | 327469at2759 |
TreeFami | TF318648 |
Family and domain databases
CDDi | cd10374, SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME
110 120 130 140 150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD
160 170 180 190 200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM
210 220 230 240 250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA
260 270 280 290 300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR
360 370 380 390 400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN
410 420 430 440 450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL
460 470 480 490 500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT
510 520 530 540 550
WDQVAEVLSW QFSSTTKRGL SIEQLSTLAE KLLGPGVNYS GCQITWAKFC
560 570 580 590 600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
610 620 630 640 650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF
660 670 680 690 700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG
710 720 730 740 750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG
760 770
QFESLTFDME LNSECATSPM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ470570 mRNA Translation: ABF21150.1 |
RefSeqi | NP_001038045.1, NM_001044580.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ470570 mRNA Translation: ABF21150.1 |
RefSeqi | NP_001038045.1, NM_001044580.1 |
3D structure databases
SMRi | Q19S50 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000018439 |
PTM databases
iPTMneti | Q19S50 |
Proteomic databases
PaxDbi | Q19S50 |
PeptideAtlasi | Q19S50 |
PRIDEi | Q19S50 |
Genome annotation databases
Organism-specific databases
CTDi | 6774 |
Phylogenomic databases
eggNOGi | KOG3667, Eukaryota |
HOGENOMi | CLU_014189_3_0_1 |
InParanoidi | Q19S50 |
OrthoDBi | 327469at2759 |
TreeFami | TF318648 |
Gene expression databases
Bgeei | ENSSSCG00000017403, Expressed in lung and 37 other tissues |
Family and domain databases
CDDi | cd10374, SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAT3_PIG | |
Accessioni | Q19S50Primary (citable) accession number: Q19S50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | July 11, 2006 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families