Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger SWIM domain-containing protein 7

Gene

ZSWIM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 114SWIM-typePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

  • double-strand break repair via homologous recombination Source: UniProtKB
  • protein stabilization Source: UniProtKB

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 7
Alternative name(s):
SWIM domain-containing and Srs2-interacting protein 1 homolog
SWIM-type zinc finger domain-containing protein 7
Gene namesi
Name:ZSWIM7
Synonyms:SWS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000214941.7
HGNCiHGNC:26993 ZSWIM7
MIMi614535 gene
neXtProtiNX_Q19AV6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214941
PharmGKBiPA162411055

Polymorphism and mutation databases

BioMutaiZSWIM7
DMDMi121940600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003074031 – 140Zinc finger SWIM domain-containing protein 7Add BLAST140

Proteomic databases

MaxQBiQ19AV6
PaxDbiQ19AV6
PeptideAtlasiQ19AV6
PRIDEiQ19AV6
ProteomicsDBi61179

PTM databases

iPTMnetiQ19AV6
PhosphoSitePlusiQ19AV6

Expressioni

Gene expression databases

BgeeiENSG00000214941
CleanExiHS_ZSWIM7
ExpressionAtlasiQ19AV6 baseline and differential
GenevisibleiQ19AV6 HS

Organism-specific databases

HPAiHPA054681

Interactioni

Subunit structurei

Interacts with RAD51D and XRCC3; involved in homologous recombination repair. Interacts with SWSAP1; they form a functional complex involved in homologous recombination repair and stabilize each other.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SWSAP1Q6NVH77EBI-5281647,EBI-5281637

Protein-protein interaction databases

BioGridi125919, 8 interactors
IntActiQ19AV6, 4 interactors
STRINGi9606.ENSP00000382218

Structurei

3D structure databases

ProteinModelPortaliQ19AV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SWS1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 114SWIM-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IWUY Eukaryota
ENOG4112D11 LUCA
GeneTreeiENSGT00390000017523
HOGENOMiHOG000006441
HOVERGENiHBG105170
InParanoidiQ19AV6
OMAiLKFVFGS
OrthoDBiEOG091G0SHF
PhylomeDBiQ19AV6
TreeFamiTF339438

Family and domain databases

InterProiView protein in InterPro
IPR007527 Znf_SWIM
PfamiView protein in Pfam
PF04434 SWIM, 1 hit
PROSITEiView protein in PROSITE
PS50966 ZF_SWIM, 1 hit

Sequencei

Sequence statusi: Complete.

Q19AV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVLPAVVE ELLSEMAAAV QESARIPDEY LLSLKFLFGS SATQALDLVD
60 70 80 90 100
RQSITLISSP SGRRVYQVLG SSSKTYTCLA SCHYCSCPAF AFSVLRKSDS
110 120 130 140
ILCKHLLAVY LSQVMRTCQQ LSVSDKQLTD ILLMEKKQEA
Length:140
Mass (Da):15,386
Last modified:July 11, 2006 - v1
Checksum:i4DECCC679C537F18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ530600 mRNA Translation: ABF72190.1
CCDSiCCDS42266.1
RefSeqiNP_001036162.1, NM_001042697.1
NP_001036163.1, NM_001042698.1
UniGeneiHs.593985

Genome annotation databases

EnsembliENST00000399277; ENSP00000382218; ENSG00000214941
ENST00000472495; ENSP00000419138; ENSG00000214941
GeneIDi125150
KEGGihsa:125150
UCSCiuc002gpe.4 human

Similar proteinsi

Entry informationi

Entry nameiZSWM7_HUMAN
AccessioniPrimary (citable) accession number: Q19AV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 11, 2006
Last modified: July 18, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health