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Entry version 85 (31 Jul 2019)
Sequence version 1 (11 Jul 2006)
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Protein
Submitted name:

ROBO2 isoform a

Gene

Robo2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ROBO2 isoform aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Robo2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1890110 Robo2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei879 – 901HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500418740833 – 1527Sequence analysisAdd BLAST1495

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q19AB3

PRoteomics IDEntifications database

More...
PRIDEi
Q19AB3

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q19AB3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 142Ig-likeInterPro annotationAdd BLAST97
Domaini148 – 235Ig-likeInterPro annotationAdd BLAST88
Domaini240 – 324Ig-likeInterPro annotationAdd BLAST85
Domaini333 – 428Ig-likeInterPro annotationAdd BLAST96
Domaini436 – 523Ig-likeInterPro annotationAdd BLAST88
Domaini543 – 637Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini656 – 754Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini758 – 855Fibronectin type-IIIInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1081 – 1147DisorderedSequence analysisAdd BLAST67
Regioni1186 – 1216DisorderedSequence analysisAdd BLAST31
Regioni1244 – 1428DisorderedSequence analysisAdd BLAST185
Regioni1440 – 1527DisorderedSequence analysisAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1081 – 1105PolarSequence analysisAdd BLAST25
Compositional biasi1201 – 1216PolarSequence analysisAdd BLAST16
Compositional biasi1273 – 1287AcidicSequence analysisAdd BLAST15
Compositional biasi1300 – 1344PolarSequence analysisAdd BLAST45
Compositional biasi1386 – 1420PolarSequence analysisAdd BLAST35
Compositional biasi1443 – 1459PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1475 – 1493PolarSequence analysisAdd BLAST19

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4222 Eukaryota
ENOG410XPQS LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010267

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q19AB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRQESICG RPWTWTPGLL MLIILGIHQG SGQGQGSRLR QEDFPPRIVE
60 70 80 90 100
HPSDVIVSKG EPTTLNCKAE GRPTPTIEWY KDGERVETDK DDPRSHRMLL
110 120 130 140 150
PSGSLFFLRI VHGRRSKPDE GSYVCVARNY LGEAVSRNAS LEVALLRDDF
160 170 180 190 200
RQNPTDVVVA AGEPAILECQ PPRGHPEPTI YWKKDKVRID DKEERISIRG
210 220 230 240 250
GKLMISNTRK SDAGMYTCVG TNMVGERDSD PAELTVFERP TFLRRPINQV
260 270 280 290 300
VLEEEAVEFR CQVQGDPQPT VRWKKDDADL PRGRYDIKDD YTLRIKKAMS
310 320 330 340 350
TDEGTYVCIA ENRVGKVEAS ATLTVRVRPV APPQFVVRPR DQIVAQGRTV
360 370 380 390 400
TFPCETKGNP QPAVFWQKEG SQNLLFPNQP QQPNSRCSVS PTGDLTITNI
410 420 430 440 450
QRSDAGYYIC QALTVAGSIL AKAQLEVTDV LTDRPPPIIL QGPINQTLAV
460 470 480 490 500
DGTALLKCKA TGEPLPVISW LKEGFTFLGR DPRATIQDQG TLQIKNLRIS
510 520 530 540 550
DTGTYTCVAT SSSGETSWSA VLDVTESGAT ISKNYDMNDL PGPPSKPQVT
560 570 580 590 600
DVSKNSVTLS WQPGTPGVLP ASAYIIEAFS QSVSNSWQTV ANHVKTTLYT
610 620 630 640 650
VRGLRPNTIY LFMVRAINPQ GLSDPSPMSD PVRTQDISPP AQGVDHRQVQ
660 670 680 690 700
KELGDVVVRL HNPVVLTPTT VQVTWTVDRQ PQFIQGYRVM YRQTSGLQAS
710 720 730 740 750
TVWQNLDAKV PTERSAVLVN LKKGVTYEIK VRPYFNEFQG MDSESKTVRT
760 770 780 790 800
TEEAPSAPPQ SVTVLTVGSH NSTSISVSWD PPPADHQNGI IQEYKIWCLG
810 820 830 840 850
NETRFHINKT VDAAIRSVVI GGLFPGIQYR VEVAASTSAG VGVKSEPQPI
860 870 880 890 900
IIGGRNEVVI TENNNSITEQ ITDVVKQPAF IAGIGGACWV ILMGFSIWLY
910 920 930 940 950
WRRKKRKGLS NYAVTFQRGD GGLMSNGSRP GLLNAGDPNY PWLADSWPAT
960 970 980 990 1000
SLPVNNSNSG PNEIGNFGRG DVLPPVPGQG DKTATMLSDG AIYSSIDFTT
1010 1020 1030 1040 1050
KTTYNSSSQI TQATPYATTQ ILHSNSIHEL AVDLPDPQWK SSVQQKTDLM
1060 1070 1080 1090 1100
GFGYSLPDQN KGNNALLYIP DYRLAEGLSN RMPHNQSQDF STTSSHNSSE
1110 1120 1130 1140 1150
RSGSLSGGKG GKKKKTKNSS KAQKNNGSTW ANVPLPPPPV QPLPGTELGH
1160 1170 1180 1190 1200
YAAEQENGYD SDSWCPPLPV QTYLHQGMED ELEEDEDRVP TPPVRGVASS
1210 1220 1230 1240 1250
PAISFGQQST ATLTPSPREE MQPMLQAHLD ELTRAYQFDI AKQTWHIQSN
1260 1270 1280 1290 1300
TPPPQPPAPP LGYVSGALIS DLETDVPDED ADDEEEPLEI PRPLGALDQT
1310 1320 1330 1340 1350
PGSSMDNLDS SVTGKAFSSS QRQRPTSPFS TDSNTSAAQN QSQRPRPTKK
1360 1370 1380 1390 1400
HKGGQMDPQP VLPHRREGMP DDLPPPPDPP PGQGLRQQIG LSQHSGNVEN
1410 1420 1430 1440 1450
STERKGSSLE RQQAANLEDT KSSLDCPAKT VLEWQRQTQD WINSTERQEE
1460 1470 1480 1490 1500
TRKAPHKQGV GSEESLVPYS KPSFPSPGGH SSSGTSSSKG STGPRKADVL
1510 1520
RGSHQRNAND LLDIGYVGSN SQGQFTE
Length:1,527
Mass (Da):167,249
Last modified:July 11, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i343BB4FDAC8B3D65
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ533875 mRNA Translation: ABF83432.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
uc007zrg.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ533875 mRNA Translation: ABF83432.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiQ19AB3

Proteomic databases

PeptideAtlasiQ19AB3
PRIDEiQ19AB3

Genome annotation databases

UCSCiuc007zrg.1 mouse

Organism-specific databases

MGIiMGI:1890110 Robo2

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
HOGENOMiHOG000010267

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Robo2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ19AB3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19AB3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 31, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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