UniProtKB - Q19AB2 (Q19AB2_MOUSE)
Protein
Submitted name:
ROBO2 isoform b
Gene
Robo2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- axon guidance receptor activity Source: Ensembl
- identical protein binding Source: Ensembl
GO - Biological processi
- apoptotic process involved in luteolysis Source: Ensembl
- brain development Source: Ensembl
- cellular response to hormone stimulus Source: Ensembl
- homophilic cell adhesion via plasma membrane adhesion molecules Source: Ensembl
- negative regulation of negative chemotaxis Source: Ensembl
- positive regulation of axonogenesis Source: Ensembl
- spinal cord development Source: Ensembl
- ureteric bud development Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: ROBO2 isoform bImportedSubmitted name: Roundabout homolog 2Imported |
Gene namesi | Name:Robo2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1890110, Robo2 |
Subcellular locationi
Other locations
- cell surface Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 860 – 882 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015097045 | 22 – 1508 | Sequence analysisAdd BLAST | 1487 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000052516, Expressed in pes and 227 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 127 | Ig-likeInterPro annotationAdd BLAST | 97 | |
Domaini | 133 – 220 | Ig-likeInterPro annotationAdd BLAST | 88 | |
Domaini | 225 – 309 | Ig-likeInterPro annotationAdd BLAST | 85 | |
Domaini | 314 – 409 | Ig-likeInterPro annotationAdd BLAST | 96 | |
Domaini | 417 – 504 | Ig-likeInterPro annotationAdd BLAST | 88 | |
Domaini | 524 – 618 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 637 – 735 | Fibronectin type-IIIInterPro annotationAdd BLAST | 99 | |
Domaini | 739 – 836 | Fibronectin type-IIIInterPro annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1062 – 1128 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 1167 – 1197 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1225 – 1409 | DisorderedSequence analysisAdd BLAST | 185 | |
Regioni | 1421 – 1508 | DisorderedSequence analysisAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1062 – 1086 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1182 – 1197 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1254 – 1268 | AcidicSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1281 – 1325 | PolarSequence analysisAdd BLAST | 45 | |
Compositional biasi | 1333 – 1353 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1367 – 1401 | PolarSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1424 – 1440 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1456 – 1474 | PolarSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Immunoglobulin domainARBA annotation, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156324 |
OrthoDBi | 45439at2759 |
TreeFami | TF351053 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 4 hits |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q19AB2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPLMFTLLL LFGFLCIQID GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL
60 70 80 90 100
NCKAEGRPTP TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR
110 120 130 140 150
SKPDEGSYVC VARNYLGEAV SRNASLEVAL LRDDFRQNPT DVVVAAGEPA
160 170 180 190 200
ILECQPPRGH PEPTIYWKKD KVRIDDKEER ISIRGGKLMI SNTRKSDAGM
210 220 230 240 250
YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE AVEFRCQVQG
260 270 280 290 300
DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKAMSTDEGT YVCIAENRVG
310 320 330 340 350
KVEASATLTV RAPPQFVVRP RDQIVAQGRT VTFPCETKGN PQPAVFWQKE
360 370 380 390 400
GSQNLLFPNQ PQQPNSRCSV SPTGDLTITN IQRSDAGYYI CQALTVAGSI
410 420 430 440 450
LAKAQLEVTD VLTDRPPPII LQGPINQTLA VDGTALLKCK ATGEPLPVIS
460 470 480 490 500
WLKEGFTFLG RDPRATIQDQ GTLQIKNLRI SDTGTYTCVA TSSSGETSWS
510 520 530 540 550
AVLDVTESGA TISKNYDMND LPGPPSKPQV TDVSKNSVTL SWQPGTPGVL
560 570 580 590 600
PASAYIIEAF SQSVSNSWQT VANHVKTTLY TVRGLRPNTI YLFMVRAINP
610 620 630 640 650
QGLSDPSPMS DPVRTQDISP PAQGVDHRQV QKELGDVVVR LHNPVVLTPT
660 670 680 690 700
TVQVTWTVDR QPQFIQGYRV MYRQTSGLQA STVWQNLDAK VPTERSAVLV
710 720 730 740 750
NLKKGVTYEI KVRPYFNEFQ GMDSESKTVR TTEEAPSAPP QSVTVLTVGS
760 770 780 790 800
HNSTSISVSW DPPPADHQNG IIQEYKIWCL GNETRFHINK TVDAAIRSVV
810 820 830 840 850
IGGLFPGIQY RVEVAASTSA GVGVKSEPQP IIIGGRNEVV ITENNNSITE
860 870 880 890 900
QITDVVKQPA FIAGIGGACW VILMGFSIWL YWRRKKRKGL SNYAVTFQRG
910 920 930 940 950
DGGLMSNGSR PGLLNAGDPN YPWLADSWPA TSLPVNNSNS GPNEIGNFGR
960 970 980 990 1000
GDVLPPVPGQ GDKTATMLSD GAIYSSIDFT TKTTYNSSSQ ITQATPYATT
1010 1020 1030 1040 1050
QILHSNSIHE LAVDLPDPQW KSSVQQKTDL MGFGYSLPDQ NKGNNALLYI
1060 1070 1080 1090 1100
PDYRLAEGLS NRMPHNQSQD FSTTSSHNSS ERSGSLSGGK GGKKKKTKNS
1110 1120 1130 1140 1150
SKAQKNNGST WANVPLPPPP VQPLPGTELG HYAAEQENGY DSDSWCPPLP
1160 1170 1180 1190 1200
VQTYLHQGME DELEEDEDRV PTPPVRGVAS SPAISFGQQS TATLTPSPRE
1210 1220 1230 1240 1250
EMQPMLQAHL DELTRAYQFD IAKQTWHIQS NTPPPQPPAP PLGYVSGALI
1260 1270 1280 1290 1300
SDLETDVPDE DADDEEEPLE IPRPLRALDQ TPGSSMDNLD SSVTGKAFSS
1310 1320 1330 1340 1350
SQRQRPTSPF STDSNTSAAQ NQSQRPRPTK KHKGGRMDPQ PVLPHRREGM
1360 1370 1380 1390 1400
PDDLPPPPDP PPGQGLRQQI GLSQHSGNVE NSTERKGSSL ERQQAANLED
1410 1420 1430 1440 1450
TKSSLDCPAK TVLEWQRQTQ DWINSTERQE ETRKAPHKQG VGSEESLVPY
1460 1470 1480 1490 1500
SKPSFPSPGG HSSSGTSSSK GSTGPRKADV LRGSHQRNAN DLLDIGYVGS
NSQGQFTE
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ7TPD3 | ROBO2_MOUSE | Roundabout homolog 2 | Robo2 Kiaa1568 | 1,470 | Annotation score: | ||
E9Q6A0 | E9Q6A0_MOUSE | Roundabout homolog 2 | Robo2 | 1,377 | Annotation score: | ||
A0A2I3BQB9 | A0A2I3BQB9_MOUSE | Roundabout homolog 2 | Robo2 | 1,065 | Annotation score: | ||
A0A2I3BR72 | A0A2I3BR72_MOUSE | Roundabout homolog 2 | Robo2 | 1,512 | Annotation score: | ||
A0A338P6D2 | A0A338P6D2_MOUSE | Roundabout homolog 2 | Robo2 | 793 | Annotation score: | ||
E9PYK2 | E9PYK2_MOUSE | Roundabout homolog 2 | Robo2 | 207 | Annotation score: | ||
A0A338P6R3 | A0A338P6R3_MOUSE | Roundabout homolog 2 | Robo2 | 178 | Annotation score: | ||
A0A338P6W2 | A0A338P6W2_MOUSE | Roundabout homolog 2 | Robo2 | 219 | Annotation score: | ||
A0A338P7C8 | A0A338P7C8_MOUSE | Roundabout homolog 2 | Robo2 | 149 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC112155 Genomic DNA No translation available. AC122049 Genomic DNA No translation available. AC129203 Genomic DNA No translation available. AC134452 Genomic DNA No translation available. AC158234 Genomic DNA No translation available. AC162374 Genomic DNA No translation available. DQ533876 mRNA Translation: ABF83433.1 |
RefSeqi | NP_780758.3, NM_175549.4 |
Genome annotation databases
Ensembli | ENSMUST00000117785; ENSMUSP00000112776; ENSMUSG00000052516 |
GeneIDi | 268902 |
UCSCi | uc007zrh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC112155 Genomic DNA No translation available. AC122049 Genomic DNA No translation available. AC129203 Genomic DNA No translation available. AC134452 Genomic DNA No translation available. AC158234 Genomic DNA No translation available. AC162374 Genomic DNA No translation available. DQ533876 mRNA Translation: ABF83433.1 |
RefSeqi | NP_780758.3, NM_175549.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 2693, 239 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000117785; ENSMUSP00000112776; ENSMUSG00000052516 |
GeneIDi | 268902 |
UCSCi | uc007zrh.1, mouse |
Organism-specific databases
CTDi | 6092 |
MGIi | MGI:1890110, Robo2 |
Phylogenomic databases
GeneTreei | ENSGT00940000156324 |
OrthoDBi | 45439at2759 |
TreeFami | TF351053 |
Miscellaneous databases
BioGRID-ORCSi | 268902, 0 hits in 12 CRISPR screens |
ChiTaRSi | Robo2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052516, Expressed in pes and 227 other tissues |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 4 hits |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q19AB2_MOUSE | |
Accessioni | Q19AB2Primary (citable) accession number: Q19AB2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 11, 2006 |
Last sequence update: | July 11, 2006 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |