We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q19A41 (KLF14_MOUSE)
Protein
Krueppel-like factor 14
Gene
Klf14
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 195 – 224 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 225 – 254 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 255 – 282 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 28 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- positive regulation of sphingolipid mediated signaling pathway Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 14 |
Gene namesi | Name:Klf14 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3577024, Klf14 |
VEuPathDBi | HostDB:ENSMUSG00000073209 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000294169 | 1 – 325 | Krueppel-like factor 14Add BLAST | 325 |
Proteomic databases
PaxDbi | Q19A41 |
PRIDEi | Q19A41 |
ProteomicsDBi | 264948 |
PTM databases
PhosphoSitePlusi | Q19A41 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000073209, Expressed in embryo and 126 other tissues |
Genevisiblei | Q19A41, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000099122 |
Miscellaneous databases
RNActi | Q19A41, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 153 – 196 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 270 – 325 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 182 – 196 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 277 – 295 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 305 – 325 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 195 – 224 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 225 – 254 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 255 – 282 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 28 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163415 |
HOGENOMi | CLU_002678_33_2_1 |
InParanoidi | Q19A41 |
OMAi | GVLWIPP |
OrthoDBi | 1308225at2759 |
PhylomeDBi | Q19A41 |
TreeFami | TF351003 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
Q19A41-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAAVACLDY FAAECLVSMS TRAVLHRRAT DPEGASAAAV SEVGAVSRES
60 70 80 90 100
AGKGTGSRGV LWIPPVLQVP TPSPGEGDGA PHLLAASALA DLSCGAREDF
110 120 130 140 150
REDSEEAPCA STSCFEPTWC SSPTGGSEPT QAFFEDELSD AESSCSDSAI
160 170 180 190 200
LDAPEASEEP DDSGEVPEGP PGARPAPSTG PTYRRRQITP ASKRHQCSFH
210 220 230 240 250
GCNKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT
260 270 280 290 300
GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRPEPPP
310 320
PAMVESSGSD SSSSSGQETS FTACL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ534758 mRNA Translation: ABF82394.1 |
CCDSi | CCDS51744.1 |
RefSeqi | NP_001128565.1, NM_001135093.1 |
Genome annotation databases
Ensembli | ENSMUST00000101589; ENSMUSP00000099122; ENSMUSG00000073209 |
GeneIDi | 619665 |
KEGGi | mmu:619665 |
UCSCi | uc012ejp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ534758 mRNA Translation: ABF82394.1 |
CCDSi | CCDS51744.1 |
RefSeqi | NP_001128565.1, NM_001135093.1 |
3D structure databases
SMRi | Q19A41 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000099122 |
PTM databases
PhosphoSitePlusi | Q19A41 |
Proteomic databases
PaxDbi | Q19A41 |
PRIDEi | Q19A41 |
ProteomicsDBi | 264948 |
Protocols and materials databases
Antibodypediai | 73306, 81 antibodies from 16 providers |
Genome annotation databases
Ensembli | ENSMUST00000101589; ENSMUSP00000099122; ENSMUSG00000073209 |
GeneIDi | 619665 |
KEGGi | mmu:619665 |
UCSCi | uc012ejp.1, mouse |
Organism-specific databases
CTDi | 136259 |
MGIi | MGI:3577024, Klf14 |
VEuPathDBi | HostDB:ENSMUSG00000073209 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163415 |
HOGENOMi | CLU_002678_33_2_1 |
InParanoidi | Q19A41 |
OMAi | GVLWIPP |
OrthoDBi | 1308225at2759 |
PhylomeDBi | Q19A41 |
TreeFami | TF351003 |
Miscellaneous databases
BioGRID-ORCSi | 619665, 0 hits in 64 CRISPR screens |
ChiTaRSi | Sp6, mouse |
PROi | PR:Q19A41 |
RNActi | Q19A41, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000073209, Expressed in embryo and 126 other tissues |
Genevisiblei | Q19A41, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF14_MOUSE | |
Accessioni | Q19A41Primary (citable) accession number: Q19A41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | July 11, 2006 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families