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Entry version 151 (07 Oct 2020)
Sequence version 4 (21 Aug 2007)
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Protein

Vacuolar protein sorting-associated protein 41 homolog

Gene

vps-41

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301). Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine (PubMed:24501423). May mediate the tethering of autophagosomes with lysosomes (PubMed:24374177). Has a role in the negative regulation of apoptosis (PubMed:15837622). Required for uptake of exogenous dsRNA which is used in experimental RNA silencing (PubMed:16862146).By similarity1 Publication5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri839 – 893RING-type; atypicalPROSITE-ProRule annotationAdd BLAST55

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Protein transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 41 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vps-41Imported
ORF Names:F32A6.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F32A6.3a ; CE37009 ; WBGene00017974 ; vps-41
F32A6.3b ; CE40762 ; WBGene00017974 ; vps-41
F32A6.3c ; CE40763 ; WBGene00017974 ; vps-41

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

In 1-cell to 20-cell stage embryos, there is defective autophagosome degradation with an accumulation of lgg-1- and lgg-2-positive autophagosomes and paternal mitochondria close to the nuclei (PubMed:24374177). Clusters of cell corpses in the distal region of the body and show no dsRNA uptake (PubMed:15837622). Reduced number of gut granules in the adult intestine (PubMed:24501423). Endosome/lysosome fusion defects in coelomocytes (PubMed:26783301). Double knockout with either sorf-1 or sorf-2 RNAi results in larger endosomes and larger lysosomes and thus suppresses the endosome/lysosome fusion defects in coelomocytes in the vps-41 single mutant (PubMed:26783301). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in the formation of large late endosomes/lysosomes, but with simultaneous expression of rab-5- and rab-7-positive vesicles on the basal side of gut cells (PubMed:25273556).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002128241 – 901Vacuolar protein sorting-associated protein 41 homologAdd BLAST901

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q19954

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q19954

PeptideAtlas

More...
PeptideAtlasi
Q19954

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00017974, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probable component of the homotypic fusion and vacuole protein sorting (HOPS) complex consisting of the core class C Vps proteins vps-11, vps-16, vps-18, and which further associates with vps-33.1, vps-39 and vps-41.

By similarity

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1136, HOPS complex

STRING: functional protein association networks

More...
STRINGi
6239.F32A6.3c

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati618 – 760CHCRAdd BLAST143

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS41 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri839 – 893RING-type; atypicalPROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2066, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000481

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001285_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q19954

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGTHNGN

Database of Orthologous Groups

More...
OrthoDBi
722805at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q19954

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR000547, Clathrin_H-chain/VPS_repeat
IPR011990, TPR-like_helical_dom_sf
IPR016902, VPS41
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
IPR001841, Znf_RING

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00637, Clathrin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028921, VPS41, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00299, CLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50236, CHCR, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform c (identifier: Q19954-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDETHENEAS DSFDPVFENS YHDDVTFNTE DDDEPPLEPR FKYERLKGEE
60 70 80 90 100
TLPFMKTATF TSIDLHDKFI AIGTATGLIY ILDHHGYGNF DSVPPLKPHR
110 120 130 140 150
CAVSKVKFDE TGSYVLSCAN DSKIVVSGVG NDKLCCTINI QVMPKSIYFS
160 170 180 190 200
PDFIRQQSGH CFIMGERNLV LYEKRMFQYK ASSLYSGSER DGFIHCCSWN
210 220 230 240 250
ENLIAFTNDT GTRVYERGAE RIITSVQPSH DVDRVRSSRS PPKHTWMPEN
260 270 280 290 300
NLVIGWADTV TILKIRDDDG VKKGEVHHIF HVSMFICGIS YIPESGIDNM
310 320 330 340 350
ELFLVGLQLE GEDFDDCASV ISTVTTLTAL ESSACTILKT SVIRPLGLKE
360 370 380 390 400
FELQSEDMIE SVKLSNHTLP YMIHGLGIPY LATYFILTTK HIIMAVPYGP
410 420 430 440 450
EDGIRWRLKY KLYDEALDMA KHNADLLSKT DLSPKKVGRM IIEGYLTGKR
460 470 480 490 500
ARAAASRLPL ICGECKEEWE WAVNQFEEVK LCTLLAEVLP DGTPTLDPEC
510 520 530 540 550
YQKVLIACLF NNVKQFRKLV QTWSPDLYMT SFIIDRTQWR IQQISKSGNL
560 570 580 590 600
ADVDETERVL MDALAHLYLY ERKYESALKI LMSCQDFQIF NVIDKHQLFD
610 620 630 640 650
LVKDQITELM NINSERALRL LLDNADSVEP SFVMEKIGRQ PKLQLAYLTK
660 670 680 690 700
LMSRNEGTEF ADKAVQLYAE YDQKKLLPFL RKNANYNVNK ARKLCSDKGY
710 720 730 740 750
IEETIYLLAK SGNHYDAVKM MVREYRNMEK VIDYCKDQND PDLWIHLLGV
760 770 780 790 800
VAEFPAHFSQ LIIEASNCLD PLLIMDKLPD DSDIPNLSEA LDKLLVDYTN
810 820 830 840 850
HAELQQCCYD STLNDLNVLT QGLISAADES VSVNIVSRCS LCAQIIINSN
860 870 880 890 900
QETTKKFSDI KVFKCGHIFH LACSTSEMER RQSIEEGLCI ACSDQIELIN

V
Length:901
Mass (Da):102,579
Last modified:August 21, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C81730B21CD5DF0
GO
Isoform a (identifier: Q19954-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:759
Mass (Da):86,688
Checksum:iF23891404DD6E9E8
GO
Isoform b (identifier: Q19954-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.
     808-823: CYDSTLNDLNVLTQGL → TFGYFYFAGGLKVEHR
     824-901: Missing.

Show »
Length:681
Mass (Da):78,222
Checksum:i43CBD58C87B845AF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0274451 – 142Missing in isoform a and isoform b. CuratedAdd BLAST142
Alternative sequenceiVSP_027446808 – 823CYDST…LTQGL → TFGYFYFAGGLKVEHR in isoform b. CuratedAdd BLAST16
Alternative sequenceiVSP_027447824 – 901Missing in isoform b. CuratedAdd BLAST78

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080679 Genomic DNA Translation: CCD65714.1
FO080679 Genomic DNA Translation: CCD65718.1
FO080679 Genomic DNA Translation: CCD65724.1
FO081274 Genomic DNA Translation: CCD70397.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T16236

NCBI Reference Sequences

More...
RefSeqi
NP_001033544.1, NM_001038455.3
NP_001033545.2, NM_001038456.3
NP_001123142.1, NM_001129670.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F32A6.3a.1; F32A6.3a.1; WBGene00017974 [Q19954-2]
F32A6.3b.1; F32A6.3b.1; WBGene00017974 [Q19954-3]
F32A6.3c.1; F32A6.3c.1; WBGene00017974 [Q19954-1]

UCSC genome browser

More...
UCSCi
F32A6.3b, c. elegans [Q19954-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080679 Genomic DNA Translation: CCD65714.1
FO080679 Genomic DNA Translation: CCD65718.1
FO080679 Genomic DNA Translation: CCD65724.1
FO081274 Genomic DNA Translation: CCD70397.1
PIRiT16236
RefSeqiNP_001033544.1, NM_001038455.3
NP_001033545.2, NM_001038456.3
NP_001123142.1, NM_001129670.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-1136, HOPS complex
STRINGi6239.F32A6.3c

Proteomic databases

EPDiQ19954
PaxDbiQ19954
PeptideAtlasiQ19954

Genome annotation databases

EnsemblMetazoaiF32A6.3a.1; F32A6.3a.1; WBGene00017974 [Q19954-2]
F32A6.3b.1; F32A6.3b.1; WBGene00017974 [Q19954-3]
F32A6.3c.1; F32A6.3c.1; WBGene00017974 [Q19954-1]
UCSCiF32A6.3b, c. elegans [Q19954-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180800
WormBaseiF32A6.3a ; CE37009 ; WBGene00017974 ; vps-41
F32A6.3b ; CE40762 ; WBGene00017974 ; vps-41
F32A6.3c ; CE40763 ; WBGene00017974 ; vps-41

Phylogenomic databases

eggNOGiKOG2066, Eukaryota
GeneTreeiENSGT00390000000481
HOGENOMiCLU_001285_2_2_1
InParanoidiQ19954
OMAiVGTHNGN
OrthoDBi722805at2759
PhylomeDBiQ19954

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q19954

Gene expression databases

BgeeiWBGene00017974, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000547, Clathrin_H-chain/VPS_repeat
IPR011990, TPR-like_helical_dom_sf
IPR016902, VPS41
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
IPR001841, Znf_RING
PfamiView protein in Pfam
PF00637, Clathrin, 1 hit
PIRSFiPIRSF028921, VPS41, 1 hit
SMARTiView protein in SMART
SM00299, CLH, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50236, CHCR, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS41_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q19954
Secondary accession number(s): A3RMR9, A3RMS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 21, 2007
Last modified: October 7, 2020
This is version 151 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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